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General Anesthetic

Dexmedetomidine for Unconsciousness (UN-CONSCIOUS Trial)

Phase 4
Waitlist Available
Led By Robert A Pearce, MD, PhD
Research Sponsored by University of Wisconsin, Madison
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up intraoperative (during sedation-- up to 8 hours)
Awards & highlights

UN-CONSCIOUS Trial Summary

This trial will test how well changes in brainwave activity during anesthesia can predict when a person will wake up.

Eligible Conditions
  • Unconsciousness
  • Consciousness

UN-CONSCIOUS Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~intraoperative (during sedation-- up to 8 hours)
This trial's timeline: 3 weeks for screening, Varies for treatment, and intraoperative (during sedation-- up to 8 hours) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Occipital Delta Power Spectral Density by Conscious State and Study Group.
Secondary outcome measures
Effect of Study Drug on Ability to Correctly Identify Images
Effect of Study Drug on Ability to Correctly Identify Shapes/Images
Effect of Study Drug on Ability to Form Implicit Memory
+1 more

Side effects data

From 2020 Phase 4 trial • 798 Patients • NCT02004613
57%
Clinically important hypotension
9%
Clinically important bradycardia
1%
infection
1%
stroke
1%
Atelectasis
1%
Hemorrhage
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo
Dexmedetomidine

UN-CONSCIOUS Trial Design

1Treatment groups
Experimental Treatment
Group I: Drug AdministratedExperimental Treatment4 Interventions
Sedatives will be administered to participants while their brain activity is measured.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ketamine
FDA approved
Propofol
FDA approved
Dexmedetomidine
FDA approved
Midazolam
FDA approved

Find a Location

Who is running the clinical trial?

University of Wisconsin, MadisonLead Sponsor
1,182 Previous Clinical Trials
3,167,352 Total Patients Enrolled
Robert A Pearce, MD, PhDPrincipal InvestigatorProfessor and chair of Anesthesiology at UW- Madison

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study
2017. "UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03284307.
~5 spots leftby Apr 2025
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