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Steroids for Thyroid Disease

Phase 4
Waitlist Available
Led By Dawn K Elfenbein
Research Sponsored by University of Wisconsin, Madison
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline (2-4 weeks prior to surgery), up to 10 weeks (6 weeks post-op), up to 30 weeks (6 months post-op)
Awards & highlights

Study Summary

This trial will see if a short course of prednisone can help reduce inflammation in people with autoimmune, inflammatory thyroid disease before surgery. Up to 30 people will be enrolled for 7 months.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline (2-4 weeks prior to surgery), up to 10 weeks (6 weeks post-op), up to 30 weeks (6 months post-op)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (2-4 weeks prior to surgery), up to 10 weeks (6 weeks post-op), up to 30 weeks (6 months post-op) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Antibody-mediated Cytokine Levels
Change in Short Form Health Survey (SF-12) Mental Component Score (MCS)
Change in Short Form Health Survey (SF-12) Physical Component Score (PCS)
+3 more
Secondary outcome measures
Number of Participants With Surgical Complications: Recurrent Laryngeal Nerve (RLN) Injury
Surgical Complications: Parathyroid Hormone (PTH) Level
Ultrasound Doppler Quantification of Blood Flow

Trial Design

2Treatment groups
Active Control
Group I: SteroidsActive Control1 Intervention
Participants randomized to the steroid arm will be given a prescription for prednisone 20mg daily for 7 days prior to surgery, otherwise, pre-operative standard of care
Group II: No SteroidsActive Control1 Intervention
Pre-operative Standard of Care

Find a Location

Who is running the clinical trial?

University of Wisconsin, MadisonLead Sponsor
1,186 Previous Clinical Trials
3,169,417 Total Patients Enrolled
Dawn K ElfenbeinPrincipal InvestigatorUniversity of Wisconsin, Madison

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Preoperative Steroids in Autoimmune Thyroid Disease
2020. "Preoperative Steroids in Autoimmune Thyroid Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04542278.
~7 spots leftby Apr 2025
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