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SLC19A3 Inhibitor

Trimethporim + thiamine combination for Beriberi

Phase 4
Waitlist Available
Led By Kathleen M Giacomini
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up as determined by blood/urine levels taken over the course of 2-3 cycles (each cycle is 3 days with a 5-14 day washout in between cycles)
Awards & highlights

Study Summary

This trial will explore if taking a drug and a vitamin together affects how the body uses Vitamin B1.

Eligible Conditions
  • Beriberi
  • Thiamine Deficiency

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~as determined by blood/urine levels taken over the course of 2-3 cycles (each cycle is 3 days with a 5-14 day washout in between cycles)
This trial's timeline: 3 weeks for screening, Varies for treatment, and as determined by blood/urine levels taken over the course of 2-3 cycles (each cycle is 3 days with a 5-14 day washout in between cycles) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Area Under the Concentration-Time Curve (AUC 0-72h)
Assess the effects of SLC19A3 inhibitors by Cmax
Secondary outcome measures
Determine the effect of genetic variants of thiamine transporters
Investigate metabolic signatures reflecting the activity of TPP-dependent enzymes

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Trimethporim + thiamine combinationExperimental Treatment2 Interventions
5mg thiamine tablet and 300mg trimethoprim tablet by mouth. This arm will be included in both Parts 1 and 2 of the study.
Group II: Metformin + thiamine combinationExperimental Treatment2 Interventions
5mg thiamine tablet and 1000mg metformin tablet by mouth. This arm will be included in only Part 1 of the study.
Group III: Thiamine onlyActive Control1 Intervention
5mg thiamine tablet by mouth. This arm will be included in both Parts 1 and 2 of the study.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Vitamin B1
2018
Completed Phase 4
~200
Trimethoprim
FDA approved
Thiamine
FDA approved

Find a Location

Who is running the clinical trial?

University of California, San FranciscoLead Sponsor
2,505 Previous Clinical Trials
15,237,548 Total Patients Enrolled
Tufts UniversityOTHER
265 Previous Clinical Trials
661,867 Total Patients Enrolled
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH
2,358 Previous Clinical Trials
4,315,067 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the eligibility criterion for this clinical trial restricted to those aged under 55?

"This medical research is accepting individuals aged 18 or older and younger than 65."

Answered by AI

Am I eligible for participation in this scientific experiment?

"In order to qualify for this research, applicants must have thiamine deficiency and be between 18-65 years of age. There are a total of 21 spots available in the study."

Answered by AI

What malady is the Trimethporim + thiamine combination most effective in remedying?

"Trimethoprim + thiamine is a widely used therapy for cholera, but it also can be beneficial in treating stunted growth, vitamin deficiency, and bronchitis."

Answered by AI

What risks do patients face when taking Trimethporim plus thiamine together?

"The safety of the Trimethporim + thiamine combination was assessed as a 3, considering its Phase 4 status indicates it has already been approved."

Answered by AI

Is this research initiative currently seeking participants?

"Definitely. Per clinicaltrials.gov, this trial is currently recruiting participants and was originally posted on January 28th 2019 with the last edit occurring November 30th 2022. The researchers need to enroll 21 patients from a single site."

Answered by AI

Is there a limit to the number of participants enrolled in this trial?

"Affirmative. The figures on clinicaltrials.gov confirm that enrollment for this medical research is currently in process - the trial was first posted on January 28th 2019 and last edited November 30th 2022, with 21 patients being sought from a single center."

Answered by AI

Are there other research reports on the efficacy of combining Trimethporim and thiamine?

"Currently, there are 194 active trials researching Trimethporim + thiamine combination with 47 in the terminal phase. The dynamic is largely concentrated around Rockville, Maryland but 1954 sites across the world offer clinical trials concerning this medication duo."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine
2019. "The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03746106.
~1 spots leftby Apr 2025
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