Exercise + Liraglutide for Metabolic Syndrome
(ZQL008 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The primary objective of this study is to examine whether exercise training alone, liraglutide treatment alone or exercise training plus liraglutide treatment increases cardiac and skeletal muscle microvascular blood volume, improves vascular function of the conduit vessels, and enhances insulin's metabolic action in humans with Metabolic Syndrome. Subjects will be randomized to one of the 4 groups: control, exercise training, liraglutide treatment, and exercise + liraglutide. They will be studied at the baseline and then after 24 weeks of intervention.
Do I need to stop my current medications for the trial?
You can continue taking certain medications if the doses have been stable for at least 3 months. These include medications like ACE inhibitors, ARBs, statins, and others listed in the trial criteria.
Is the combination of exercise and liraglutide safe for humans?
How does the treatment of exercise and liraglutide differ from other treatments for metabolic syndrome?
This treatment combines exercise, which improves insulin sensitivity and body composition, with liraglutide, a medication that helps control blood sugar levels and supports weight loss. This dual approach targets multiple aspects of metabolic syndrome, potentially offering more comprehensive benefits than treatments focusing on a single component.678910
What data supports the effectiveness of the treatment Exercise + Liraglutide for Metabolic Syndrome?
Research shows that regular exercise can improve blood sugar control, insulin sensitivity, and reduce risk factors for heart disease in people with metabolic syndrome. Exercise is as effective as some diabetes medications in managing blood sugar levels and can also help with weight loss when combined with a healthy diet.610111213
Who Is on the Research Team?
Zhenqi Liu, MD
Principal Investigator
Division of Endocrinology and Metabolism, University of Virginia
Are You a Good Fit for This Trial?
Adults aged 21-60 with Metabolic Syndrome, not currently very active, and have a stable weight (BMI between 25-35) can join. They must meet at least three criteria like large waist size, high triglycerides or blood sugar, low HDL cholesterol, or high blood pressure. Those on certain stable medications may also qualify.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are randomized to one of four groups: control, exercise training, liraglutide treatment, or exercise + liraglutide for 24 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Exercise training
- Liraglutide
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Virginia
Lead Sponsor
National Institutes of Health (NIH)
Collaborator
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator