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Local Anesthetic

Right sided catheter normal saline and left sided catheter bupivacaine 0.25% for Postoperative Pain

Phase 4
Waitlist Available
Led By Brian M Ilfeld, MD,MS
Research Sponsored by University of California, San Diego
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up postoperative day 2 (00:01 through afternoon data-collection time point)
Awards & highlights

Study Summary

This study is evaluating whether a catheter and infusion of local anesthetic can increase the duration of the effects of a single-injection ESP block.

Eligible Conditions
  • Postoperative Pain
  • Surgical Incisions
  • Acute Pain

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day of surgery
This trial's timeline: 3 weeks for screening, Varies for treatment, and day of surgery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
"Average" pain during postoperative day 1 as measured using the numeric rating scale, collected postoperative day 1 for the time since midnight. This is a 0-10 Likert scale measuring pain level with 0 = no pain and 10 = worst imaginable pain scale
Secondary outcome measures
"Average" pain during postoperative day 2 which is the "average" pain measured using the numeric rating scale, collected postoperative day 2 for the time since midnight. This is a 0-10 Likert scale measuring pain level with 0 = no pain and 10=worst pain
"Average" pain during postoperative day 3 which is the "average" pain measured using the numeric rating scale, collected postoperative day 3 for the time since midnight. It is a 0-10 Likert scale measuring pain level with 0=no pain and 10=worst pain
"Current" pain during postoperative days 1-3 which is the current pain experienced using the numeric rating scale, collected postoperative days 1-3. This is a 0-10 Likert scale measuring pain level with 0 = no pain and 10 = worst imaginable pain
+7 more
Other outcome measures
Antiemetic use
Hospital length of stay
Indication for surgery
+10 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Right sided catheter normal saline and left sided catheter bupivacaine 0.25%Experimental Treatment2 Interventions
This is a split body study. Bilateral erector spinae plane catheters will be inserted and study fluid is administered bilaterally. Normal saline will be administered through the right-sided catheter while bupivacaine 0.25% will be administered through the left-sided catheter. Both infusion pumps will be programmed to deliver a basal infusion of 1 mL/h and an automatic intermittent bolus of 20 mL every 4 hours.
Group II: Right sided catheter bupivacaine 0.25% and left sided catheter normal salineExperimental Treatment2 Interventions
This is a split body study. Bilateral erector spinae plane catheters will be inserted and study fluid is administered bilaterally. Bupivacaine 0.25 will be administered through the right-sided catheter while normal saline will be administered through the left-sided catheter. Both infusion pumps will be programmed to deliver a basal infusion of 1 mL/h and an automatic intermittent bolus of 20 mL every 4 hours.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Bupivacaine 0.25%
2016
Completed Phase 4
~950
Normal Saline
2019
Completed Phase 4
~1770

Find a Location

Who is running the clinical trial?

University of California, San DiegoLead Sponsor
1,120 Previous Clinical Trials
1,521,407 Total Patients Enrolled
6 Trials studying Postoperative Pain
401 Patients Enrolled for Postoperative Pain
Brian M Ilfeld, MD,MSPrincipal InvestigatorUCSD Medical Center
1 Previous Clinical Trials
138 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Continuous Erector Spinae Plane Blocks to Treat Postoperative Pain After Open Gynecologic Procedures Via a Low Transverse (Pfannenstiel) Incision
Brian M. Ilfeld, MD, MS 2022. "Continuous Erector Spinae Plane Blocks to Treat Postoperative Pain After Open Gynecologic Procedures Via a Low Transverse (Pfannenstiel) Incision". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05082155.
~0 spots leftby Apr 2025
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