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Local Anesthetic

Buffered 2% lidocaine with 1:100,000 epinephrine for Irreversible Pulpitis

Phase 4
Recruiting
Research Sponsored by Indiana University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 20 minutes post-drug administration
Awards & highlights

Study Summary

The purpose of this study is to determine whether one type of anesthetic (numbing medicine) will work better at numbing the nerve in a tooth than using a different type of anesthetic. A second purpose is to see if the time needed to numb the nerve in a tooth is different between the two anesthetics.

Eligible Conditions
  • Irreversible Pulpitis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 20 minutes post-drug administration
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 20 minutes post-drug administration for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Profoundness of pulpal anesthesia
Secondary outcome measures
Onset of pulpal anesthesia

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Buffered 2% lidocaine with 1:100,000 epinephrineExperimental Treatment2 Interventions
Buffered local anesthetic (addition of sodium bicarbonate to make a 10% buffered solution)
Group II: Unbuffered 2% lidocaine with 1:100,000 epinephrineActive Control1 Intervention
Standard local anesthetic
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Lidocaine
FDA approved

Find a Location

Who is running the clinical trial?

Indiana UniversityLead Sponsor
980 Previous Clinical Trials
982,942 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed With Symptomatic Irreversible Pulpitis
Kenneth J. Spolnik 2022. "Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed With Symptomatic Irreversible Pulpitis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05227300.
All > Anesthesia
~13 spots leftby Apr 2025
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