Study Summary
This trial will look at how the flu vaccine affects social behavior in people by comparing them with a placebo group.
Eligible Conditions
- Inflammation
- Psychology and Social Science
- Social Defeat
- Social Interaction
Treatment Effectiveness
Effectiveness Progress
This is further along than 93% of similar trials
Study Objectives
3 Primary · 0 Secondary · Reporting Duration: within approximately 24 hours of treatment
Hour 24
Difference in behaviorally coded social engagement between two social targets
Difference in self-reported social connection between two social targets
Difference in unfair monetary offers accepted
Trial Safety
Safety Progress
This is further along than 85% of similar trials
Trial Design
2 Treatment Groups
Influenza Vaccine
1 of 2
Sham Vaccine
1 of 2
Experimental Treatment
Non-Treatment Group
100 Total Participants · 2 Treatment Groups
Primary Treatment: Influenza Vaccine · Has Placebo Group · Phase 4
Influenza Vaccine
Biological
Experimental Group · 1 Intervention: Influenza vaccine · Intervention Types: BiologicalSham Vaccine
Biological
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: BiologicalTreatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Influenza vaccine
2014
Completed Phase 4
~5870
Trial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: within approximately 24 hours of treatment
Who is running the clinical trial?
University of North Carolina, Chapel HillLead Sponsor
1,381 Previous Clinical Trials
3,929,204 Total Patients Enrolled
23 Trials studying Inflammation
5,239 Patients Enrolled for Inflammation
U.S. National Science FoundationFED
31 Previous Clinical Trials
8,773 Total Patients Enrolled
1 Trials studying Inflammation
200 Patients Enrolled for Inflammation
Keely Muscatell, PhDPrincipal InvestigatorUniversity of North Carolina, Chapel Hill
Eligibility Criteria
Age 18 - 35 · All Participants · 2 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:You must be between 18 and 35 years old.
You need to bring a friend of the same gender who is willing to participate in the second study session.
References
- SCHACHTER S, SINGER JE. Cognitive, social, and physiological determinants of emotional state. Psychol Rev. 1962 Sep;69:379-99. doi: 10.1037/h0046234. No abstract available.
- Eisenberger NI, Inagaki TK, Mashal NM, Irwin MR. Inflammation and social experience: an inflammatory challenge induces feelings of social disconnection in addition to depressed mood. Brain Behav Immun. 2010 May;24(4):558-63. doi: 10.1016/j.bbi.2009.12.009. Epub 2010 Jan 4.
- Kuhlman KR, Robles TF, Haydon MD, Dooley L, Boyle CC, Bower JE. Early life stress sensitizes individuals to the psychological correlates of mild fluctuations in inflammation. Dev Psychobiol. 2020 Apr;62(3):400-408. doi: 10.1002/dev.21908. Epub 2019 Sep 6.
- Inagaki TK, Muscatell KA, Irwin MR, Moieni M, Dutcher JM, Jevtic I, Breen EC, Eisenberger NI. The role of the ventral striatum in inflammatory-induced approach toward support figures. Brain Behav Immun. 2015 Feb;44:247-52. doi: 10.1016/j.bbi.2014.10.006. Epub 2014 Oct 16.
- Sterling P. Allostasis: a model of predictive regulation. Physiol Behav. 2012 Apr 12;106(1):5-15. doi: 10.1016/j.physbeh.2011.06.004. Epub 2011 Jun 12.
- Siegel EH, Sands MK, Van den Noortgate W, Condon P, Chang Y, Dy J, Quigley KS, Barrett LF. Emotion fingerprints or emotion populations? A meta-analytic investigation of autonomic features of emotion categories. Psychol Bull. 2018 Apr;144(4):343-393. doi: 10.1037/bul0000128. Epub 2018 Feb 1.
- Avitsur R, Cohen E, Yirmiya R. Effects of interleukin-1 on sexual attractivity in a model of sickness behavior. Physiol Behav. 1997 Dec 31;63(1):25-30. doi: 10.1016/s0031-9384(97)00381-8.
- Barrett LF. The theory of constructed emotion: an active inference account of interoception and categorization. Soc Cogn Affect Neurosci. 2017 Jan 1;12(1):1-23. doi: 10.1093/scan/nsw154. Erratum In: Soc Cogn Affect Neurosci. 2017 Nov 1;12(11):1833.
- Slavich GM, Irwin MR. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull. 2014 May;140(3):774-815. doi: 10.1037/a0035302. Epub 2014 Jan 13.
- Slavich GM, Cole SW. The Emerging Field of Human Social Genomics. Clin Psychol Sci. 2013 Jul;1(3):331-348. doi: 10.1177/2167702613478594.
- Storbeck J, Clore GL. Affective Arousal as Information: How Affective Arousal Influences Judgments, Learning, and Memory. Soc Personal Psychol Compass. 2008 Sep 1;2(5):1824-1843. doi: 10.1111/j.1751-9004.2008.00138.x.
- Hennessy MB, Deak T, Schiml PA. Sociality and sickness: have cytokines evolved to serve social functions beyond times of pathogen exposure? Brain Behav Immun. 2014 Mar;37:15-20. doi: 10.1016/j.bbi.2013.10.021. Epub 2013 Oct 31.
- Muscatell KA, Dedovic K, Slavich GM, Jarcho MR, Breen EC, Bower JE, Irwin MR, Eisenberger NI. Greater amygdala activity and dorsomedial prefrontal-amygdala coupling are associated with enhanced inflammatory responses to stress. Brain Behav Immun. 2015 Jan;43:46-53. doi: 10.1016/j.bbi.2014.06.201. Epub 2014 Jul 9.
- Glaser R, Robles TF, Sheridan J, Malarkey WB, Kiecolt-Glaser JK. Mild depressive symptoms are associated with amplified and prolonged inflammatory responses after influenza virus vaccination in older adults. Arch Gen Psychiatry. 2003 Oct;60(10):1009-14. doi: 10.1001/archpsyc.60.10.1009.
- Kemeny ME. Psychobiological responses to social threat: evolution of a psychological model in psychoneuroimmunology. Brain Behav Immun. 2009 Jan;23(1):1-9. doi: 10.1016/j.bbi.2008.08.008. Epub 2008 Sep 10.
- Richeson JA, Shelton JN. Negotiating Interracial Interactions: Costs, Consequences, and Possibilities. Current Directions in Psychological Science. 2007;16(6):316-320. doi:10.1111/j.1467-8721.2007.00528.x
- Willette AA, Lubach GR, Coe CL. Environmental context differentially affects behavioral, leukocyte, cortisol, and interleukin-6 responses to low doses of endotoxin in the rhesus monkey. Brain Behav Immun. 2007 Aug;21(6):807-15. doi: 10.1016/j.bbi.2007.01.007. Epub 2007 Mar 1.
- Kuhlman KR, Robles TF, Dooley LN, Boyle CC, Haydon MD, Bower JE. Within-subject associations between inflammation and features of depression: Using the flu vaccine as a mild inflammatory stimulus. Brain Behav Immun. 2018 Mar;69:540-547. doi: 10.1016/j.bbi.2018.02.001. Epub 2018 Feb 16.
- Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 2008 Jan;9(1):46-56. doi: 10.1038/nrn2297.
- Bluthe RM, Dantzer R, Kelley KW. Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat. Brain Res. 1992 Feb 28;573(2):318-20. doi: 10.1016/0006-8993(92)90779-9.
- Christian LM, Iams JD, Porter K, Glaser R. Inflammatory responses to trivalent influenza virus vaccine among pregnant women. Vaccine. 2011 Nov 8;29(48):8982-7. doi: 10.1016/j.vaccine.2011.09.039. Epub 2011 Sep 22.
- Hart BL. Biological basis of the behavior of sick animals. Neurosci Biobehav Rev. 1988 Summer;12(2):123-37. doi: 10.1016/s0149-7634(88)80004-6.
- Boyle, Chloe C., Kate R. Kuhlman, Larissa N. Dooley, Marcie D. Haydon, Theodore F. Robles, Yuen-Siang Ang, Diego A. Pizzagalli, and Julienne E. Bower. 2019. “Inflammation and Dimensions of Reward Processing Following Exposure to the Influenza Vaccine”. Psychoneuroendocrinology. Elsevier BV. doi:10.1016/j.psyneuen.2018.11.024.
- Muscatell KA, Moieni M, Inagaki TK, Dutcher JM, Jevtic I, Breen EC, Irwin MR, Eisenberger NI. Exposure to an inflammatory challenge enhances neural sensitivity to negative and positive social feedback. Brain Behav Immun. 2016 Oct;57:21-29. doi: 10.1016/j.bbi.2016.03.022. Epub 2016 Mar 28.
- Bartz JA, Zaki J, Bolger N, Ochsner KN. Social effects of oxytocin in humans: context and person matter. Trends Cogn Sci. 2011 Jul;15(7):301-9. doi: 10.1016/j.tics.2011.05.002. Epub 2011 Jun 21.
- Slavich GM, Way BM, Eisenberger NI, Taylor SE. Neural sensitivity to social rejection is associated with inflammatory responses to social stress. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14817-22. doi: 10.1073/pnas.1009164107. Epub 2010 Aug 2.
- Murray DR, Haselton MG, Fales M, Cole SW. Falling in love is associated with immune system gene regulation. Psychoneuroendocrinology. 2019 Feb;100:120-126. doi: 10.1016/j.psyneuen.2018.09.043. Epub 2018 Oct 2.
- Pressman SD, Cohen S, Miller GE, Barkin A, Rabin BS, Treanor JJ. Loneliness, social network size, and immune response to influenza vaccination in college freshmen. Health Psychol. 2005 May;24(3):297-306. doi: 10.1037/0278-6133.24.3.297. Erratum In: Health Psychol. 2005 Jul;24(4):348.
- Berger J, Heinrichs M, von Dawans B, Way BM, Chen FS. Cortisol modulates men's affiliative responses to acute social stress. Psychoneuroendocrinology. 2016 Jan;63:1-9. doi: 10.1016/j.psyneuen.2015.09.004. Epub 2015 Sep 5.
- Yee JR, Prendergast BJ. Sex-specific social regulation of inflammatory responses and sickness behaviors. Brain Behav Immun. 2010 Aug;24(6):942-51. doi: 10.1016/j.bbi.2010.03.006. Epub 2010 Mar 17.
- Eisenberger NI, Moieni M, Inagaki TK, Muscatell KA, Irwin MR. In Sickness and in Health: The Co-Regulation of Inflammation and Social Behavior. Neuropsychopharmacology. 2017 Jan;42(1):242-253. doi: 10.1038/npp.2016.141. Epub 2016 Aug 2.
- Gassen J, Hill SE. Why inflammation and the activities of the immune system matter for social and personality psychology (and not only for those who study health). Soc Personal Psychol Compass. May 2019:e12471. doi:10.1111/spc3.12471
- Dhabhar FS, Malarkey WB, Neri E, McEwen BS. Stress-induced redistribution of immune cells--from barracks to boulevards to battlefields: a tale of three hormones--Curt Richter Award winner. Psychoneuroendocrinology. 2012 Sep;37(9):1345-68. doi: 10.1016/j.psyneuen.2012.05.008. Epub 2012 Jun 22.
- Leschak CJ, Eisenberger NI. Two Distinct Immune Pathways Linking Social Relationships With Health: Inflammatory and Antiviral Processes. Psychosom Med. 2019 Oct;81(8):711-719. doi: 10.1097/PSY.0000000000000685.
- Dickerson SS, Kemeny ME. Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychol Bull. 2004 May;130(3):355-91. doi: 10.1037/0033-2909.130.3.355.
- Moieni M, Irwin MR, Jevtic I, Olmstead R, Breen EC, Eisenberger NI. Sex differences in depressive and socioemotional responses to an inflammatory challenge: implications for sex differences in depression. Neuropsychopharmacology. 2015 Jun;40(7):1709-16. doi: 10.1038/npp.2015.17. Epub 2015 Jan 19.
- Bilbo SD, Klein SL, DeVries AC, Nelson RJ. Lipopolysaccharide facilitates partner preference behaviors in female prairie voles. Physiol Behav. 1999 Dec 1-15;68(1-2):151-6. doi: 10.1016/s0031-9384(99)00154-7.
- Aron A, Melinat E, Aron EN, Vallone RD, Bator RJ. The Experimental Generation of Interpersonal Closeness: A Procedure and Some Preliminary Findings. Pers Soc Psychol Bull. 1997;23(4):363-377. doi:10.1177/0146167297234003
- Tsai MY, Hanson NQ, Straka RJ, Hoke TR, Ordovas JM, Peacock JM, Arends VL, Arnett DK. Effect of influenza vaccine on markers of inflammation and lipid profile. J Lab Clin Med. 2005 Jun;145(6):323-7. doi: 10.1016/j.lab.2005.03.009.
- 2022. "Body and Social Behavior". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05654441.
Frequently Asked Questions
Is eligibility for this research trial restricted to individuals under 30 years of age?
"The eligibility criteria for this medical trial necessitates that participants must be above the age of consent and below 35 years old." - Anonymous Online Contributor
Unverified Answer
Has the Influenza Vaccine received clearance from the FDA?
"There is a substantial body of evidence which has deemed the influenza vaccine safe, thus it received an overall score of 3." - Anonymous Online Contributor
Unverified Answer
Is enrollment currently available for this research project?
"This medical trial is actively enrolling patients, as indicated by the information available on clinicaltrials.gov. The study was first posted to this platform on October 17th 2022 and underwent its most recent update on December 8th of the same year." - Anonymous Online Contributor
Unverified Answer
For which types of individuals is this trial most suitable?
"This study requires a cohort of 100 psychologically and sociologically able adults aged eighteen to thirty-five. In addition, these participants must have an individual from the same gender willing to participate in the second trial session." - Anonymous Online Contributor
Unverified Answer
What is the total enrollment capacity of this investigation?
"Affirmative. The information held on clinicaltrials.gov suggests that this trial is actively seeking participants, with the original post appearing on October 17th 2022 and a recent update occurring December 8th 2022. A total of 100 patients need to be recruited from one medical centre." - Anonymous Online Contributor
Unverified Answer