Empagliflozin for Prediabetic State

Phase-Based Progress Estimates
3
Effectiveness
3
Safety
Oregon State University, Corvallis, OR
Prediabetic State+4 More
Empagliflozin - Drug
Eligibility
18 - 65
All Sexes
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Study Summary

The overall purpose of this study is to identify how empagliflozin (a drug commonly used to treat type 2 diabetes) impacts skeletal muscle metabolic health among adults with prediabetes. Our aims are to: 1) Test the ability of empagliflozin to improve regulation of glucose metabolism (i.e., blood sugar) among overweight and obese individuals with prediabetes, and 2) Identify mechanisms to explain how empagliflozin may improve skeletal muscle glucose metabolism. We hypothesize empagliflozin will improve regulation of glucose metabolism due to changes in whole-body and skeletal muscle metabolism (e.g., increased rates of whole-body fat oxidation, evidence of impaired skeletal muscle mitochondrial respiratory function and increased energetic stress, lower accumulation of skeletal muscle lipids and improved skeletal muscle insulin signaling compared with placebo treatment).

Eligible Conditions

  • Prediabetic State
  • PreDiabetes
  • Obesity

Treatment Effectiveness

Effectiveness Progress

3 of 3
This is further along than 93% of similar trials

Other trials for Prediabetic State

Study Objectives

1 Primary · 7 Secondary · Reporting Duration: Fasting plasma glucose is measured before the start of the intervention (baseline) and during week 13 of the intervention.

Week 13
Fasting plasma glucose concentration
Week 13
Insulin-stimulated glucose disposal
Week 12
Oral glucose tolerance
Week 13
Skeletal muscle energetic stress
Week 13
Skeletal muscle insulin signaling
Week 13
Skeletal muscle lipids
Week 13
Skeletal muscle mitochondrial respiratory function
Week 13
Whole-body fat oxidation

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Other trials for Prediabetic State

Side Effects for

10 mg Empagliflozin
15%Cardiac failure
7%Urinary tract infection
7%Hypertension
7%Hypotension
6%Fall
6%Renal impairment
6%Hyperkalaemia
5%Atrial fibrillation
5%Diabetes mellitus
4%Hyperuricaemia
4%Anaemia
3%Pneumonia
3%Acute kidney injury
2%Cardiac failure congestive
2%Death
2%COVID-19
2%Acute myocardial infarction
1%Cardiac failure chronic
1%Chronic obstructive pulmonary disease
1%Ventricular tachycardia
1%Sepsis
1%Syncope
1%Angina unstable
1%Coronary artery disease
1%Angina pectoris
1%Myocardial infarction
1%Ischaemic stroke
1%Transient ischaemic attack
1%Chronic kidney disease
1%COVID-19 pneumonia
1%Cerebrovascular accident
1%Basal cell carcinoma
1%Cellulitis
0%Colitis ulcerative
0%Cardiac cirrhosis
0%Enterocolitis
0%Haemoptysis
0%Injection site phlebitis
0%Chronic gastritis
0%Bacteraemia
0%Lung abscess
0%Procedural complication
0%Peripheral venous disease
0%Cholangitis infective
0%Gastritis erosive
0%Subacute pancreatitis
0%Rib fracture
0%Scleroderma
0%Actinic keratosis
0%Liver injury
0%Fungal oesophagitis
0%Metastases to abdominal wall
0%Severe fever with thrombocytopenia syndrome
0%Chronic inflammatory demyelinating polyradiculoneuropathy
0%Hepatic cancer metastatic
0%Stress cardiomyopathy
0%Lung cancer metastatic
0%Pneumoperitoneum
0%Meningitis bacterial
0%Hypoacusis
0%Retinal artery occlusion
0%Diverticulum intestinal
0%Gastric ulcer perforation
0%Gastrointestinal perforation
0%Oesophageal rupture
0%Rectal ulcer
0%General physical health deterioration
0%Pyrexia
0%Bile duct stone
0%Cholangitis acute
0%Cholestasis
0%Liver disorder
0%Corneal graft rejection
0%Abdominal sepsis
0%Abscess neck
0%Bronchitis
0%Cholecystitis infective
0%Infective exacerbation of chronic obstructive airways disease
0%Orchitis
0%Staphylococcal sepsis
0%Suspected COVID-19
0%Sternal fracture
0%Traumatic spinal cord compression
0%Adenoid cystic carcinoma
0%Colon cancer stage 0
0%Coma
0%Presyncope
0%Transient global amnesia
0%Device malfunction
0%Suicide attempt
0%Bronchitis chronic
0%Bronchospasm
0%Rash erythematous
0%Abdominal infection
0%Pyelonephritis acute
0%Volvulus
0%Traumatic haemorrhage
0%Meningioma benign
0%Haemorrhagic ascites
0%Coronavirus infection
0%Subdural haemorrhage
0%Papillary cystadenoma lymphomatosum
0%Thrombosis in device
0%Umbilical hernia
0%Diabetic retinopathy
0%Open angle glaucoma
0%Pulmonary contusion
0%Gastrooesophageal reflux disease
0%Pacemaker generated arrhythmia
0%Strangulated hernia
0%Keratinising squamous cell carcinoma of nasopharynx
0%Cerebral small vessel ischaemic disease
0%Senile dementia
0%Haemorrhagic infarction
0%Vasculitis
0%Amyloidosis
0%Ankle fracture
0%Metastases to liver
0%Vessel puncture site bruise
0%Palpitations
0%Salivary gland calculus
0%Sarcopenia
0%Soft tissue necrosis
0%Spinal stenosis
0%Synovitis
0%Adenocarcinoma gastric
0%Immune thrombocytopenia
0%Pancytopenia
0%Coagulopathy
0%Hypochromic anaemia
0%Atrial tachycardia
0%Aortic valve incompetence
0%Adams-Stokes syndrome
0%Arrhythmia supraventricular
0%Arrhythmia
0%Bundle branch block right
0%Left ventricular failure
0%Cardiac amyloidosis
0%Cardiogenic shock
0%Myocardial ischaemia
0%Coronary artery stenosis
0%Left ventricular dysfunction
0%Cardiorenal syndrome
0%Cardiovascular disorder
0%Coronary artery insufficiency
0%Coronary artery occlusion
0%Mitral valve disease
0%Mitral valve incompetence
0%Pyloric stenosis
0%Deafness
0%Deafness bilateral
0%Prinzmetal angina
0%Sinus arrest
0%Tachyarrhythmia
0%Atrial septal defect
0%Ventricular arrhythmia
0%Ventricular failure
0%Ventricular fibrillation
0%Cholesteatoma
0%Mixed deafness
0%Hypertrophic cardiomyopathy
0%Type V hyperlipidaemia
0%Vestibular disorder
0%Basedow's disease
0%Macular hole
0%Glaucoma
0%Macular degeneration
0%Neovascular age-related macular degeneration
0%Retinal tear
0%Optic ischaemic neuropathy
0%Retinal artery embolism
0%Abdominal pain upper
0%Colitis
0%Colitis ischaemic
0%Diaphragmatic hernia
0%Diverticulum
0%Gastric haemorrhage
0%Dysphagia
0%Gastritis
0%Gastrointestinal ulcer
0%Hiatus hernia
0%Haemorrhoidal haemorrhage
0%Ileus
0%Intestinal haemorrhage
0%Intestinal infarction
0%Large intestinal stenosis
0%Mechanical ileus
0%Mesenteric artery embolism
0%Large intestine polyp
0%Lower gastrointestinal haemorrhage
0%Mesenteric artery thrombosis
0%Nausea
0%Oesophageal varices haemorrhage
0%Oesophagitis
0%Pancreatic failure
0%Pancreatitis acute
0%Rectal prolapse
0%Retroperitoneal fibrosis
0%Small intestinal obstruction
0%Small intestinal stenosis
0%Small intestinal perforation
0%Stomach mass
0%Subileus
0%Upper gastrointestinal haemorrhage
0%Asthenia
0%Malaise
0%Multiple organ dysfunction syndrome
0%Chest discomfort
0%Chest pain
0%Fatigue
0%Fibrosis
0%Gait disturbance
0%Inflammation
0%Medical device site oedema
0%Physical deconditioning
0%Oedema peripheral
0%Stent-graft endoleak
0%Sudden death
0%Sudden cardiac death
0%Biliary colic
0%Systemic inflammatory response syndrome
0%Biliary obstruction
0%Cholecystitis acute
0%Drug-induced liver injury
0%Cholelithiasis
0%Hepatic function abnormal
0%Hepatitis cholestatic
0%Hepatorenal failure
0%Jaundice
0%Allergy to vaccine
0%Anaphylactic reaction
0%Abscess limb
0%Anal abscess
0%Appendicitis
0%Arthritis bacterial
0%Atypical pneumonia
0%Breast abscess
0%Breast cellulitis
0%Bronchitis bacterial
0%Clostridium difficile colitis
0%Cystitis
0%Dengue fever
0%Device related infection
0%Device related sepsis
0%Diverticulitis
0%Diabetic foot infection
0%Enterobacter sepsis
0%Erysipelas
0%Gangrene
0%Gastroenteritis
0%Gastroenteritis norovirus
0%Gastroenteritis rotavirus
0%Gastrointestinal infection
0%Herpes zoster
0%Infected skin ulcer
0%Bladder cancer
0%Intervertebral discitis
0%Intestinal sepsis
0%Joint abscess
0%Klebsiella infection
0%Ludwig angina
0%Osteomyelitis acute
0%Parotid abscess
0%Pathogen resistance
0%Peritonsillar abscess
0%Perineal abscess
0%Periodontitis
0%Pneumonia parainfluenzae viral
0%Pneumonia pneumococcal
0%Pneumonia viral
0%Postoperative abscess
0%Pulmonary tuberculosis
0%Respiratory tract infection
0%Pyelonephritis
0%Small intestine gangrene
0%Staphylococcal bacteraemia
0%Streptococcal bacteraemia
0%Streptococcal infection
0%Streptococcal sepsis
0%Testicular abscess
0%Tooth abscess
0%Wound abscess
0%Viral upper respiratory tract infection
0%Wound infection staphylococcal
0%Wound sepsis
0%Animal bite
0%Clavicle fracture
0%Coronary artery restenosis
0%Cystitis radiation
0%Contusion
0%Dural tear
0%Craniocerebral injury
0%Epidural haemorrhage
0%Femur fracture
0%Gastrointestinal injury
0%Forearm fracture
0%Heart injury
0%Head injury
0%Hand fracture
0%Humerus fracture
0%Heat stroke
0%Joint injury
0%Joint dislocation postoperative
0%Lower limb fracture
0%Multiple fractures
0%Lumbar vertebral fracture
0%Maisonneuve fracture
0%Patella fracture
0%Muscle injury
0%Post procedural hypotension
0%Pelvic fracture
0%Post procedural haemorrhage
0%Postoperative delirium
0%Bladder neoplasm
0%Procedural pain
0%Road traffic accident
0%Scapula fracture
0%Skin injury
0%Subdural haematoma
0%Upper limb fracture
0%Traumatic fracture
0%Traumatic haemothorax
0%Urethral injury
0%Aspartate aminotransferase increased
0%Urethral stricture postoperative
0%Wrist fracture
0%Blood creatinine increased
0%Alanine aminotransferase increased
0%Anticoagulation drug level above therapeutic
0%Blood creatine phosphokinase increased
0%Blood pressure increased
0%C-reactive protein increased
0%Blood potassium increased
0%Ejection fraction decreased
0%Hepatic enzyme increased
0%Liver function test abnormal
0%Occult blood positive
0%Prostatic specific antigen abnormal
0%Weight decreased
0%Diabetic ketoacidosis
0%Fluid imbalance
0%Hypercholesterolaemia
0%Hyperinsulinaemic hypoglycaemia
0%Hypernatraemia
0%Hypophagia
0%Type 2 diabetes mellitus
0%Arthralgia
0%Compartment syndrome
0%Bladder papilloma
0%Gouty arthritis
0%Groin pain
0%Haematoma muscle
0%Joint range of motion decreased
0%Lumbar spinal stenosis
0%Osteoarthritis
0%Muscular weakness
0%Colon adenoma
0%Musculoskeletal chest pain
0%Osteitis
0%Rhabdomyolysis
0%Osteonecrosis
0%Pathological fracture
0%Brain neoplasm malignant
0%Breast cancer
0%Breast cancer female
0%Colon cancer
0%Colon cancer metastatic
0%Diffuse large B-cell lymphoma
0%Extranodal marginal zone B-cell lymphoma (MALT type)
0%Gastric adenoma
0%Gastric neoplasm
0%Intracranial tumour haemorrhage
0%Invasive ductal breast carcinoma
0%Laryngeal cancer
0%Lung carcinoma cell type unspecified recurrent
0%Invasive papillary breast carcinoma
0%Lung adenocarcinoma stage IV
0%Lung neoplasm
0%Lymphoma
0%Neoplasm malignant
0%Monoclonal gammopathy
0%Myxoid liposarcoma
0%Non-small cell lung cancer
0%Ovarian neoplasm
0%Oesophageal carcinoma
0%Prostate cancer stage IV
0%Renal adenoma
0%Renal cancer
0%Seminoma
0%Skin cancer
0%Squamous cell carcinoma of lung
0%Squamous cell carcinoma of skin
0%Squamous cell carcinoma of the oral cavity
0%Squamous cell carcinoma of the parotid gland
0%T-cell lymphoma
0%Tongue neoplasm
0%Tumour haemorrhage
0%Altered state of consciousness
0%Brain compression
0%Brain oedema
0%Brain stem ischaemia
0%Carotid artery dissection
0%Blood loss anaemia
0%Carotid artery stenosis
0%Cerebral arteriosclerosis
0%Carpal tunnel syndrome
0%Cerebellar haematoma
0%Cervical radiculopathy
0%Dizziness
0%Embolic cerebral infarction
0%Encephalomalacia
0%Encephalopathy
0%Generalised tonic-clonic seizure
0%Haemorrhagic transformation stroke
0%Headache
0%Hydrocephalus
0%Hypoglycaemic seizure
0%Intracranial aneurysm
0%Neurological symptom
0%Posterior cortical atrophy
0%Seizure
0%Thoracic radiculopathy
0%Vascular dementia
0%Vertebral artery thrombosis
0%Device dislocation
0%Disorientation
0%Anxiety
0%Bipolar I disorder
0%Bipolar disorder
0%Cystitis haemorrhagic
0%Diabetic nephropathy
0%Haematuria
0%Hydronephrosis
0%Ureterolithiasis
0%Acute pulmonary oedema
0%Dyspnoea
0%Neurogenic bladder
0%Pelvi-ureteric obstruction
0%Proteinuria
0%Renal artery stenosis
0%Renal colic
0%Renal failure
0%Urethral stenosis
0%Acquired phimosis
0%Acute respiratory distress syndrome
0%Acute respiratory failure
0%Haemothorax
0%Hydrothorax
0%Hypoxia
0%Pleurisy
0%Pneumonitis
0%Pulmonary arterial hypertension
0%Pulmonary oedema
0%Respiratory arrest
0%Respiratory distress
0%Paraneoplastic dermatomyositis
0%Psoriasis
0%Aortic aneurysm
0%Aortic aneurysm rupture
0%Arteriosclerosis
0%Circulatory collapse
0%Extremity necrosis
0%Peripheral artery aneurysm
0%Peripheral artery stenosis
0%Peripheral embolism
0%Peripheral ischaemia
0%Shock haemorrhagic
0%Subclavian vein thrombosis
0%Thrombophlebitis superficial
0%Acute coronary syndrome
0%Acute left ventricular failure
0%Aortic valve stenosis
0%Atrial flutter
0%Bradyarrhythmia
0%Bundle branch block left
0%Atrioventricular block complete
0%Atrioventricular block second degree
0%Cardiac sarcoidosis
0%Cardiac failure acute
0%Chronotropic incompetence
0%Chronic left ventricular failure
0%Microcytic anaemia
0%Cardiac ventricular thrombosis
0%Pulseless electrical activity
0%Myocarditis
0%Supraventricular tachycardia
0%Pericardial effusion
0%Torsade de pointes
0%Tricuspid valve incompetence
0%Leukocytosis
0%Silent myocardial infarction
0%Sinoatrial block
0%Sinus node dysfunction
0%Splenic infarction
0%Normocytic anaemia
0%Ventricular dyskinesia
0%Ventricular extrasystoles
0%Buried penis syndrome
0%Congenital cystic kidney disease
0%Phimosis
0%Mitral valve stenosis
0%Sudden hearing loss
0%Tinnitus
0%Vertigo
0%Amaurosis fugax
0%Hyperthyroidism
0%Hyperplasia adrenal
0%Pituitary apoplexy
0%Secondary adrenocortical insufficiency
0%Blindness transient
0%Cataract nuclear
0%Macular ischaemia
0%Macular fibrosis
0%Cataract
0%Retinal detachment
0%Abdominal mass
0%Visual acuity reduced
0%Abdominal pain
0%Vitreous haemorrhage
0%Abdominal hernia
0%Ascites
0%Chronic gastrointestinal bleeding
0%Acute abdomen
0%Barrett's oesophagus
0%Diverticulum intestinal haemorrhagic
0%Duodenitis
0%Duodenal ulcer haemorrhage
0%Enterovesical fistula
0%Faecal vomiting
0%Gastric ulcer
0%Gastric ulcer haemorrhage
0%Gastrointestinal haemorrhage
0%Gastrointestinal necrosis
0%Haematochezia
0%Incarcerated inguinal hernia
0%Intestinal angina
0%Intestinal obstruction
0%Intestinal perforation
0%Large intestinal ulcer
0%Intestinal strangulation
0%Intra-abdominal haemorrhage
0%Large intestine perforation
0%Mesenteric artery stenosis
0%Obstructive pancreatitis
0%Oesophageal achalasia
0%Oesophageal spasm
0%Pancreatitis chronic
0%Peptic ulcer
0%Retroperitoneal haemorrhage
0%Thrombosis mesenteric vessel
0%Vomiting
0%Accidental death
0%Discomfort
0%Hernia
0%Impaired healing
0%Hypothermia
0%Necrosis
0%Vascular stent occlusion
0%Vascular stent stenosis
0%Cholecystitis
0%Cholecystitis chronic
0%Cholestatic liver injury
0%Hepatic cirrhosis
0%Jaundice cholestatic
0%Ischaemic hepatitis
0%Abscess
0%Acute sinusitis
0%Bacterial food poisoning
0%Bacterial sepsis
0%Bacterial translocation
0%Bullous erysipelas
0%Cardiac valve abscess
0%Chronic sinusitis
0%Clostridium difficile infection
0%Colon gangrene
0%Complicated appendicitis
0%Diabetic gangrene
0%Dysentery
0%Endocarditis bacterial
0%Endocarditis staphylococcal
0%Enteritis infectious
0%Epididymitis
0%Gallbladder empyema
0%Gastroenteritis viral
0%Helicobacter infection
0%Infected dermal cyst
0%Infected gouty tophus
0%Infectious pleural effusion
0%Influenza
0%Klebsiella bacteraemia
0%Labyrinthitis
0%Liver abscess
0%Neurocysticercosis
0%Peritonitis bacterial
0%Peritonsillitis
0%Pneumonia bacterial
0%Postoperative wound infection
0%Prostatitis Escherichia coli
0%Pseudomembranous colitis
0%Pulmonary sepsis
0%Severe acute respiratory syndrome
0%Soft tissue infection
0%Staphylococcal skin infection
0%Tracheobronchitis
0%Systemic candida
0%Upper respiratory tract infection
0%Urosepsis
0%Accidental overdose
0%Wound infection
0%Alcohol poisoning
0%Burns second degree
0%Brain contusion
0%Burns third degree
0%Cervical vertebral fracture
0%Chest injury
0%Concussion
0%Craniofacial fracture
0%Corneal graft failure
0%Deafness traumatic
0%Dislocation of vertebra
0%Diffuse axonal injury
0%Femoral neck fracture
0%Fibula fracture
0%Genital contusion
0%Hip fracture
0%Incision site haemorrhage
0%Intentional overdose
0%Limb traumatic amputation
0%Limb injury
0%Meniscus injury
0%Overdose
0%Periprocedural myocardial infarction
0%Periprosthetic fracture
0%Post procedural complication
0%Postoperative ileus
0%Postoperative renal failure
0%Radius fracture
0%Spinal fracture
0%Subcutaneous haematoma
0%Thoracic vertebral fracture
0%Tibia fracture
0%Blood ketone body increased
0%Blood urine present
0%Glomerular filtration rate decreased
0%Troponin increased
0%Decreased appetite
0%Dehydration
0%Diarrhoea
0%Diabetic complication
0%Diabetic metabolic decompensation
0%Electrolyte imbalance
0%Fluid overload
0%Food intolerance
0%Hypercreatininaemia
0%Hypercalcaemia
0%Hyperglycaemia
0%Hyponatraemia
0%Hypokalaemia
0%Hypovolaemia
0%Ketoacidosis
0%Ketosis
0%Lactic acidosis
0%Obesity
0%Acquired claw toe
0%Arthropathy
0%Arthritis
0%Back pain
0%Bursitis
0%Dupuytren's contracture
0%Haemarthrosis
0%Intervertebral disc degeneration
0%Intervertebral disc protrusion
0%Muscle twitching
0%Myopathy
0%Myositis
0%Neck pain
0%Polymyalgia rheumatica
0%Rotator cuff syndrome
0%Sacroiliac joint dysfunction
0%Sjogren's syndrome
0%Spinal osteoarthritis
0%Spinal pain
0%Tendonitis
0%Vertebral column mass
0%Adenocarcinoma
0%Adenocarcinoma pancreas
0%Adenocarcinoma of colon
0%Adrenal gland cancer metastatic
0%Angiomyolipoma
0%Benign gastric neoplasm
0%Benign neoplasm of bladder
0%Bladder transitional cell carcinoma
0%Bladder transitional cell carcinoma stage II
0%Brain cancer metastatic
0%Brain neoplasm
0%Bronchial carcinoma
0%Clear cell renal cell carcinoma
0%Colorectal cancer
0%Gastric cancer
0%Gastrointestinal adenocarcinoma
0%Hepatocellular carcinoma
0%Intraductal proliferative breast lesion
0%Invasive lobular breast carcinoma
0%Laryngeal squamous cell carcinoma
0%Lip squamous cell carcinoma
0%Lung adenocarcinoma
0%Leiomyosarcoma
0%Lipoma
0%Lung neoplasm malignant
0%Malignant melanoma
0%Malignant neoplasm of renal pelvis
0%Malignant neoplasm progression
0%Mantle cell lymphoma
0%Metastases to central nervous system
0%Metastases to lymph nodes
0%Metastatic malignant melanoma
0%Metastatic squamous cell carcinoma
0%Myelodysplastic syndrome
0%Nasopharyngeal cancer stage I
0%Neuroendocrine carcinoma
0%Nasal sinus cancer
0%Nasopharyngeal tumour
0%Neuroendocrine tumour
0%Neuroendocrine tumour of the lung metastatic
0%Non-Hodgkin's lymphoma
0%Non-small cell lung cancer metastatic
0%Oesophageal cancer metastatic
0%Oesophageal neoplasm
0%Oesophageal squamous cell carcinoma metastatic
0%Pancreatic carcinoma metastatic
0%Parathyroid tumour benign
0%Paraneoplastic syndrome
0%Pituitary tumour benign
0%Prostate cancer
0%Plasma cell myeloma
0%Prostate cancer stage I
0%Rectal adenocarcinoma
0%Rectal adenoma
0%Rectal cancer
0%Salivary gland cancer
0%Skin cancer metastatic
0%Squamous cell carcinoma
0%Thymoma
0%Uterine leiomyoma
0%Vulval cancer
0%Brain stem stroke
0%Carotid artery disease
0%Central nervous system lesion
0%Cerebral atrophy
0%Cerebral haemorrhage
0%Cerebral infarction
0%Cerebral ischaemia
0%Cerebrospinal fluid leakage
0%Cranial nerve palsies multiple
0%Dementia Alzheimer's type
0%Disturbance in attention
0%Drop attacks
0%Demyelination
0%Embolic stroke
0%Epilepsy
0%Haemorrhagic stroke
0%Hemiparesis
0%Hepatic encephalopathy
0%Hypoaesthesia
0%Loss of consciousness
0%Migraine
0%Ischaemic cerebral infarction
0%Lumbar radiculopathy
0%Paraesthesia
0%Neuropathy peripheral
0%Parkinson's disease
0%Sciatica
0%Postresuscitation encephalopathy
0%Sensorimotor disorder
0%Speech disorder
0%Status epilepticus
0%Thalamus haemorrhage
0%Toxic encephalopathy
0%Vascular encephalopathy
0%Vertebral artery stenosis
0%Device leakage
0%Adjustment disorder
0%Anxiety disorder
0%Confusional state
0%Completed suicide
0%Nosophobia
0%Paranoia
0%Bladder tamponade
0%Calculus urinary
0%End stage renal disease
0%Ketonuria
0%Nephropathy
0%Postrenal failure
0%Renal tubular necrosis
0%Renal injury
0%Urethral caruncle
0%Urethral cyst
0%Urinary bladder rupture
0%Urinary incontinence
0%Urinary retention
0%Urinary tract obstruction
0%Benign prostatic hyperplasia
0%Vesical fistula
0%Acquired hydrocele
0%Adnexa uteri mass
0%Cervix disorder
0%Prostatitis
0%Uterine inflammation
0%Uterine polyp
0%Uterine prolapse
0%Aspiration
0%Choking
0%Combined pulmonary fibrosis and emphysema
0%Cough
0%Epistaxis
0%Hypersensitivity pneumonitis
0%Nasal polyps
0%Hypoventilation
0%Pneumonia aspiration
0%Pneumothorax
0%Pulmonary embolism
0%Pulmonary fibrosis
0%Pulmonary hypertension
0%Pulmonary mass
0%Respiratory failure
0%Sinus polyp
0%Diabetic ulcer
0%Restrictive pulmonary disease
0%Angioedema
0%Peau d'orange
0%Skin necrosis
0%Hospitalisation
0%Accelerated hypertension
0%Angiodysplasia
0%Aortic thrombosis
0%Arterial occlusive disease
0%Bleeding varicose vein
0%Cyanosis
0%Essential hypertension
0%Embolism
0%Haemorrhage
0%Hypertensive emergency
0%Hypertensive urgency
0%Hypovolaemic shock
0%Iliac artery dissection
0%Iliac artery occlusion
0%Intermittent claudication
0%Penetrating aortic ulcer
0%Orthostatic hypotension
0%Peripheral arterial occlusive disease
0%Phlebitis superficial
0%Varicose vein
0%Septic shock
0%Hypomagnesaemia
0%Conjunctival disorder
0%Haemorrhoids
0%Ileus paralytic
0%Abdominal pain lower
0%Cholangitis
0%Retinal ischaemia
0%Clostridial sepsis
0%Normal tension glaucoma
0%Endocarditis
0%Gastric polyps
0%Gastrointestinal obstruction
0%Gastrointestinal polyp
0%Large intestinal haemorrhage
0%Pancreatitis
0%Non-cardiac chest pain
0%Jaw fracture
0%Haematoma infection
0%Localised infection
0%Transaminases increased
0%Osteomyelitis
0%Superinfection
0%Systemic bacterial infection
0%Procedural shock
0%Prostate cancer stage II
0%Anticoagulation drug level below therapeutic
0%Cachexia
0%Diabetes mellitus inadequate control
0%Gout
0%Hypoglycaemia
0%Metabolic acidosis
0%Fistula
0%Muscle spasms
0%Osteoporosis
0%Pain in extremity
0%Hepatic cancer
0%Meningioma
0%Malignant melanoma in situ
0%Metastases to peritoneum
0%Neuroendocrine carcinoma of the skin
0%Pancreatic carcinoma
0%Prostate cancer metastatic
0%Renal cell carcinoma
0%Thyroid neoplasm
0%Tonsil cancer
0%Arachnoid cyst
0%Carotid artery aneurysm
0%Cerebral haematoma
0%Hypoxic-ischaemic encephalopathy
0%Dementia
0%Device failure
0%Nephrolithiasis
0%Postmenopausal haemorrhage
0%Asthma
0%Vaginal haemorrhage
0%Emphysema
0%Pleural effusion
0%Respiratory disorder
0%Pneumothorax spontaneous
0%Diabetic foot
0%Stasis dermatitis
0%Aortic dissection
0%Deep vein thrombosis
0%Dyspepsia
0%Acute lymphocytic leukaemia
0%Metastatic bronchial carcinoma
0%Metastatic neoplasm
0%Rectal neoplasm
0%Cerebellar infarction
0%Nervous system disorder
0%Paraplegia
0%Device breakage
0%Vertebrobasilar insufficiency
0%Nephropathy toxic
0%Nephrotic syndrome
0%Pyoderma gangrenosum
0%Hypertensive crisis
0%Peripheral vascular disorder
0%Shock
0%Thrombosis
0%Atrial thrombosis
0%Anaemia megaloblastic
0%Iron deficiency anaemia
0%Thrombocytopenia
0%Goitre
0%Talipes
0%Deafness neurosensory
0%Vertigo positional
0%Deafness unilateral
0%Eyelid ptosis
0%Retinal vein occlusion
0%Diverticular perforation
0%Oesophageal haemorrhage
0%Pancreatic disorder
0%Cardiac death
0%Drowning
0%Escherichia sepsis
0%Fournier's gangrene
0%Herpes zoster infection neurological
0%Infection
0%Post procedural inflammation
0%Tendon rupture
0%Flank pain
0%Adenocarcinoma metastatic
0%Benign neoplasm of testis
0%Bowen's disease
0%Endometrial adenocarcinoma
0%Gastrointestinal carcinoma
0%Glomangiopericytoma
0%Lung squamous cell carcinoma stage III
0%Malignant neoplasm of unknown primary site
0%Pancreatic neoplasm
0%Lymphadenopathy mediastinal
0%Atrioventricular block
0%Pharyngeal cancer
0%Renal neoplasm
0%Small intestine carcinoma
0%Transitional cell carcinoma
0%Cerebral artery embolism
0%Cerebral artery occlusion
0%Cerebral disorder
0%Cervical cord compression
0%Myocardial necrosis
0%Haemorrhage intracranial
0%Hypertensive encephalopathy
0%Lacunar infarction
0%Lacunar stroke
0%Disseminated intravascular coagulation
0%Subarachnoid haemorrhage
0%Tremor
0%Delirium
0%Depression
0%Post-traumatic stress disorder
0%Benign ovarian tumour
0%Hyperventilation
0%Interstitial lung disease
0%Obstructive airways disorder
0%Pleural thickening
0%Pulmonary congestion
0%Sleep apnoea syndrome
0%Skin ulcer
0%Aortic stenosis
0%Dry gangrene
0%Femoral artery aneurysm
0%Peripheral artery thrombosis
0%Phlebitis
0%Cognitive disorder
0%Parkinsonism
0%Bradycardia
0%Anaemia macrocytic
0%Vascular pseudoaneurysm
0%Supraventricular tachyarrhythmia
0%Cardiopulmonary failure
0%Adrenal insufficiency
0%Constipation
0%Intestinal pseudo-obstruction
0%Acinetobacter infection
0%Metastases to lung
0%Carotid arteriosclerosis
0%Idiopathic pulmonary fibrosis
0%Heart valve replacement
0%Malignant hypertension
0%Venous thrombosis limb
0%Sinus bradycardia
0%Ischaemic cardiomyopathy
0%Right ventricular failure
0%Cardiac arrest
0%Cardio-respiratory arrest
0%Left ventricular hypertrophy
0%Incarcerated umbilical hernia
0%Inguinal hernia
0%Intestinal polyp
0%Enteritis
0%Gastrointestinal inflammation
0%Intestinal ischaemia
0%Rectal haemorrhage
0%Melaena
0%Small intestinal haemorrhage
0%Hyperthermia
0%Hepatic failure
0%Hepatitis acute
0%Hepatorenal syndrome
0%Bursitis infective
0%Enterococcal bacteraemia
0%Helicobacter gastritis
0%Hepatitis A
0%Mastoiditis
0%Facial bones fracture
0%Large intestine infection
0%Lower respiratory tract infection
0%Peritonitis
0%Petrositis
0%Back injury
0%Bursa injury
0%Incisional hernia
0%Brain natriuretic peptide
0%Hyperglycaemic hyperosmolar nonketotic syndrome
0%Toxicity to various agents
0%Skin laceration
0%Skull fractured base
0%Spinal compression fracture
0%Exostosis
0%Costochondritis
0%Dysarthria
0%Small cell lung cancer
0%Brain injury
0%Carotid artery occlusion
0%Hemiplegia
0%Insomnia
0%Pollakiuria
0%Pemphigoid
0%Haematoma
0%Peripheral artery occlusion
0%Thrombophlebitis
This histogram enumerates side effects from a completed 2021 Phase 3 trial (NCT03057951) in the 10 mg Empagliflozin ARM group. Side effects include: Cardiac failure with 15%, Urinary tract infection with 7%, Hypertension with 7%, Hypotension with 7%, Fall with 6%.

Trial Design

2 Treatment Groups

Empagliflozin
1 of 2
Multivitamin-Placebo
1 of 2
Experimental Treatment
Non-Treatment Group

40 Total Participants · 2 Treatment Groups

Primary Treatment: Empagliflozin · Has Placebo Group · Phase 4

Empagliflozin
Drug
Experimental Group · 1 Intervention: Empagliflozin · Intervention Types: Drug
Multivitamin-Placebo
Drug
PlaceboComparator Group · 1 Intervention: Multivitamin-Placebo · Intervention Types: Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Empagliflozin
2017
Completed Phase 4
~102500

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: fasting plasma glucose is measured before the start of the intervention (baseline) and during week 13 of the intervention.
Closest Location: Oregon State University · Corvallis, OR
Photo of oregon 1Photo of oregon 2Photo of oregon 3
2008First Recorded Clinical Trial
1 TrialsResearching Prediabetic State
16 CompletedClinical Trials

Who is running the clinical trial?

Samaritan Health ServicesOTHER
3 Previous Clinical Trials
180 Total Patients Enrolled
Oregon State UniversityLead Sponsor
44 Previous Clinical Trials
8,323 Total Patients Enrolled
Sean A Newsom, Ph.D.Principal InvestigatorOregon State University
1 Previous Clinical Trials
9 Total Patients Enrolled

Eligibility Criteria

Age 18 - 65 · All Participants · 3 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You have a BMI of 26-45 kg/m2.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.