400 Participants Needed

Cognitive Behavioral Therapy for Alcoholism and Cannabis Abuse

KX
KX
Overseen ByKelly Xiao, MSc
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Centre for Addiction and Mental Health
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. However, you must be able to safely abstain from alcohol and cannabis for 12 hours before assessments.

What data supports the effectiveness of the treatment Cognitive Behavioral Therapy (CBT) for alcoholism and cannabis abuse?

Research shows that Cognitive Behavioral Therapy (CBT) is effective for treating both alcohol and cannabis use disorders. Studies have found that people who received CBT reported better outcomes, such as increased abstinence and fewer substance-related problems, compared to those who did not receive the treatment.12345

Is Cognitive Behavioral Therapy (CBT) safe for treating alcohol and cannabis use disorders?

Cognitive Behavioral Therapy (CBT) is generally considered safe for treating various substance use disorders, including alcohol and cannabis use. It is a well-established, evidence-based treatment that has been used safely in both individual and group settings.25678

How is Cognitive Behavioral Therapy (CBT) different from other treatments for alcoholism and cannabis abuse?

Cognitive Behavioral Therapy (CBT) is unique because it focuses on changing thought patterns and behaviors related to substance use, and it can be delivered in various formats, including computer-based programs, which makes it more accessible and flexible compared to traditional in-person therapy sessions.23569

What is the purpose of this trial?

This 2-arm study will recruit participants with 1) alcohol use disorder and 2) cannabis use disorder for a 12-week cognitive behavioral therapy, following a thorough baseline assessments on executive function, incentive salience, and negative emotionality.

Research Team

MS

Matthew Sloan, MD

Principal Investigator

Centre for Addiction and Mental Health

Eligibility Criteria

This trial is for adults over 18 who have been diagnosed with alcohol use disorder (AUD) or cannabis use disorder (CUD), are willing to participate in group therapy, and can abstain from substances before assessments. They must meet specific criteria for risky drinking or frequent cannabis use. Those unable to communicate in English or unwilling to follow the study's abstinence requirements cannot join.

Inclusion Criteria

I can speak and understand English well enough to give informed consent.
I can avoid alcohol, cannabis, and other substances (except tobacco) for 12 hours before tests.
Meets criteria for risky drinking, defined as > 10 drinks per week for females and > 15 drinks per week for males on average over the past 30 days (AUD group) or daily or near-daily cannabis use over the past 30 days, defined as ≥ 4 days of cannabis use per week on average (CUD group)
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Exclusion Criteria

Active suicidal ideation at time of assessment
Suicide attempt within the past month
Unstable psychiatric or medical status (e.g., acute psychosis or mania) or unstable use of another substance that may interfere with participation in groups (e.g. active fentanyl use)
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Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Participants undergo thorough baseline assessments of executive function, incentive salience, and negative emotionality

1-2 weeks

Treatment

Participants receive 12 weeks of cognitive behavioral therapy (CBT) for their respective disorders, with optional pharmacotherapy for AUD and motivational enhancement therapy for CUD

12 weeks
Weekly group therapy sessions

Follow-up

Participants are monitored for changes in drug consumption, craving, and other psychological measures

4 weeks

Treatment Details

Interventions

  • CBT
Trial Overview The study tests if assessing three brain functions—executive function, incentive salience, and negative emotionality—before treatment can predict how well people with AUD or CUD respond to therapy. Participants will receive 12 weeks of cognitive behavioral therapy (CBT), with additional pharmacotherapy for AUD if needed.
Participant Groups
2Treatment groups
Experimental Treatment
Group I: Cannabis Use DisorderExperimental Treatment1 Intervention
Participants will be treated with 12 weeks of CBT + motivational enhancement therapy for CUD (group therapy).
Group II: Alcohol Use DisorderExperimental Treatment1 Intervention
Participants will be treated with 12 weeks of CBT for AUD (group therapy) and have the option to receive evidence-based pharmacotherapy for AUD guided by a pharmacotherapy algorithm.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Centre for Addiction and Mental Health

Lead Sponsor

Trials
388
Recruited
84,200+

Innovation Fund of the Alternative Funding Plan for the Academic Health Sciences Centres of Ontario

Collaborator

Trials
1
Recruited
400+

Canadian Institutes of Health Research (CIHR)

Collaborator

Trials
1,417
Recruited
26,550,000+

AFP Innovation Fund

Collaborator

Trials
9
Recruited
1,500+

Findings from Research

A meta-analysis of 10 randomized controlled trials involving 2,027 participants found that behavioral therapies (BTs) significantly improve outcomes for cannabis use disorders compared to control conditions, with an effect size of 0.44, indicating that patients receiving BTs fared better than 66% of those in control groups.
Behavioral therapies were effective in reducing both the frequency and severity of cannabis use, as well as improving psychosocial functioning, with larger effect sizes observed in studies using waitlist controls compared to those with active control comparisons.
Behavioral therapies for treatment-seeking cannabis users: a meta-analysis of randomized controlled trials.Davis, ML., Powers, MB., Handelsman, P., et al.[2022]
A study involving 68 individuals with alcohol use disorders showed that those receiving web-based cognitive behavioral therapy (CBT4CBT) had significantly higher treatment completion rates and greater increases in the percentage of days abstinent compared to standard treatment alone.
The web-based CBT4CBT program was found to be safe and feasible, with preliminary evidence suggesting it may reduce the costs of alcohol use disorder-related services compared to standard treatment.
Randomized Trial of Computerized Cognitive Behavioral Therapy for Alcohol Use Disorders: Efficacy as a Virtual Stand-Alone and Treatment Add-On Compared with Standard Outpatient Treatment.Kiluk, BD., Devore, KA., Buck, MB., et al.[2018]
Cognitive Behavioral Therapy (CBT) is an effective treatment for adults with alcohol or other drug use disorders, showing significant efficacy compared to minimal care and usual care control conditions.
While CBT can be combined with other treatments like Motivational Interviewing and pharmacotherapy for better outcomes, it does not consistently outperform other established treatment methods, and its mechanisms of action require further investigation.
Efficacy of Cognitive Behavioral Therapy for Alcohol and Other Drug Use Disorders: Is a One-Size-Fits-All Approach Appropriate?Magill, M., Kiluk, BD., Ray, LA.[2023]

References

Behavioral therapies for treatment-seeking cannabis users: a meta-analysis of randomized controlled trials. [2022]
Randomized Trial of Computerized Cognitive Behavioral Therapy for Alcohol Use Disorders: Efficacy as a Virtual Stand-Alone and Treatment Add-On Compared with Standard Outpatient Treatment. [2018]
Efficacy of Cognitive Behavioral Therapy for Alcohol and Other Drug Use Disorders: Is a One-Size-Fits-All Approach Appropriate? [2023]
A randomized controlled trial of brief cognitive-behavioral interventions for cannabis use disorder. [2022]
Positive and negative affect in cocaine use disorder treatment: Change across time and relevance to treatment outcome. [2020]
Computerised cognitive behavioural therapy for alcohol use disorder: a pilot randomised control trial. [2019]
A pilot economic evaluation of computerized cognitive behavioral therapy for alcohol use disorder as an addition and alternative to traditional therapy. [2023]
Cognitive behavioral therapy and the nicotine transdermal patch for dual nicotine and cannabis dependence: a pilot study. [2021]
Cognitive behaviour therapy (CBT) for the treatment of co-occurring depression and substance use: current evidence and directions for future research. [2018]
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