Ketamine for Rattlesnake Envenomation

Phase-Based Progress Estimates
3
Effectiveness
3
Safety
Banner - University Medical Center, Phoenix campus, Phoenix, AZ
Rattlesnake Envenomation+1 More
Ketamine - Drug
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This is a pilot study to evaluate pain responses from two different approved medications (ketamine and fentanyl) in the treatment of pain after rattlesnake envenomation (RSE). Both medications are currently used in standard practice to treat both acute and chronic pain and are options for pain management after RSE. Multiple studies exist showing ketamine to be both safe and effective for the treatment of acute pain, and to be as good as or better than opioids for this indication. The specific comparison of ketamine to fentanyl, however, has never been studied for the treatment of acute pain after rattlesnake envenomation in the United States. The investigators plan to measure pain scores after a single dose of ketamine or fentanyl in patients shortly after being envenomated, followed by continued treatment of pain guided by the treating doctor. There will be no restrictions on additional pain medications given and no other changes to the treatment of these patients during their hospitalization. This research is important because pain after RSE can be difficult to control and may require frequent, high doses of opioids for several days. An effective non-opioid medication would be helpful both to better-control pain and to reduce exposure to opioids in this patient population. This study will compare patient-reported pain scores after receiving a single dose of ketamine or fentanyl in patients with rattlesnake bites who have been admitted to the toxicology service at Banner - University Medical Center Phoenix (BUMCP).

Eligible Conditions

  • Rattlesnake Envenomation

Treatment Effectiveness

Effectiveness Progress

3 of 3
This is further along than 93% of similar trials

Study Objectives

1 Primary · 1 Secondary · Reporting Duration: 30-120 minutes after drug administration

30-120 minutes after drug administration
Change in Pain assessment post medication
During hospitalization, up to 120 minutes
Adverse Events

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Trial Design

2 Treatment Groups

Fentanyl
1 of 2
Ketamine
1 of 2
Active Control
Experimental Treatment

40 Total Participants · 2 Treatment Groups

Primary Treatment: Ketamine · No Placebo Group · Phase 4

Ketamine
Drug
Experimental Group · 1 Intervention: Ketamine · Intervention Types: Drug
Fentanyl
Drug
ActiveComparator Group · 1 Intervention: Fentanyl · Intervention Types: Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ketamine
2011
Completed Phase 4
~1160

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 30-120 minutes after drug administration
Closest Location: Banner - University Medical Center, Phoenix campus · Phoenix, AZ
Photo of Phoenix  1Photo of Phoenix  2Photo of Phoenix  3
N/AFirst Recorded Clinical Trial
1 TrialsResearching Rattlesnake Envenomation
0 CompletedClinical Trials

Eligibility Criteria

Age 18+ · All Participants · 6 Total Inclusion Criteria

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You are able to speak and understand English.\n

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

References