NSAIDs for Chronic Kidney Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to determine if non-steroidal anti-inflammatory (NSAID) use in the postoperative setting increases the risk of acute kidney injury (AKI) in pediatric patients with mild-to-moderate chronic kidney disease (CKD). The investigators hypothesize that there is no increased risk. This will be a limited pilot study within a Pediatric Urology population, intended to inform future work in a larger patient population.
Will I have to stop taking my current medications?
The trial requires that you do not take certain medications like ACE inhibitors, ARBs, diuretics, or trimethoprim. If you are on these, you would need to stop them to participate.
Are NSAIDs safe for people with chronic kidney disease?
How do NSAIDs differ from other drugs for chronic kidney disease?
Who Is on the Research Team?
Kyle Rove, MD
Principal Investigator
Children's Hospital Colorado
Are You a Good Fit for This Trial?
This trial is for children with mild-to-moderate chronic kidney disease (CKD) who are undergoing surgery. The study aims to see if NSAIDs, commonly used for pain relief after surgery, increase the risk of acute kidney injury in these patients.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either NSAID or placebo treatment for a maximum of 5 days
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessment of acute kidney injury and pain scores
What Are the Treatments Tested in This Trial?
Interventions
- NSAIDs
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Colorado, Denver
Lead Sponsor