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ESPB with Bupivacaine and Dexamethasone for Postoperative Pain (ESPB-Spine Trial)

Phase 4
Waitlist Available
Led By Ellen Soffin, MD PhD
Research Sponsored by Hospital for Special Surgery, New York
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at baseline (holding area), pacu (hour 0), hour 6, 12, and 24 hours after surgery
Awards & highlights

ESPB-Spine Trial Summary

This trial will test whether adding a local anesthetic block called the Erector Spinae Plane Block (ESPB) to a comprehensive Enhanced Recovery Pathway (ERP) can reduce pain and opioid use in adults undergoing complex spine surgery.

Eligible Conditions
  • Postoperative Pain
  • Opioid Use Disorder

ESPB-Spine Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 24 hours after surgery
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 24 hours after surgery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Secondary outcome measures
Blinding Assessment
Opioid Related Side Effects
Pain Scores at Rest
+4 more

ESPB-Spine Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: ESPB with Bupivacaine and DexamethasoneActive Control2 Interventions
23 complex spine surgery patients will be randomized to receive intraoperative ultrasound-guided bilateral ESPB with 0.375% bupivacaine plus 2 mg preservative free dexamethasone, 25-30 mL total per side according to patient weight.
Group II: ESPB with saline placeboPlacebo Group1 Intervention
23 complex spine surgery patients will be randomized to receive intraoperative ultrasound-guided bilateral ESPB with saline placebo, 25-30 mL total per side according to patient weight.

Find a Location

Who is running the clinical trial?

Hospital for Special Surgery, New YorkLead Sponsor
243 Previous Clinical Trials
59,318 Total Patients Enrolled
6 Trials studying Postoperative Pain
333 Patients Enrolled for Postoperative Pain
Ellen Soffin, MD PhDPrincipal InvestigatorHospital for Special Surgery, New York
Ellen Soffin, MD, PhDPrincipal InvestigatorHospital for Special Surgery, New York
1 Previous Clinical Trials
56 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Erector Spinae Plane Block Versus Conventional Analgesia in Complex Spine Surgery
2019. "Erector Spinae Plane Block Versus Conventional Analgesia in Complex Spine Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04156581.
~8 spots leftby Apr 2025
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