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Naloxegol 25 MG for Postoperative Pain

Phase 4
Waitlist Available
Led By Mehmet A Turan, MD
Research Sponsored by The Cleveland Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up postoperative days 1-2 or until day of discharge whichever occurs first
Awards & highlights

Study Summary

This trial is testing whether the drug Naloxegol can reduce the side effects of opioid painkillers in people who have recently undergone surgery.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~postoperative days 1-2 or until day of discharge whichever occurs first
This trial's timeline: 3 weeks for screening, Varies for treatment, and postoperative days 1-2 or until day of discharge whichever occurs first for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Residual Urine Volume
Secondary outcome measures
Need for Indwelling Urinary Catheterization
Quality of Recovery
Side Effects of Naloxegol on Other Opioid Related Side Effects

Side effects data

From 2022 Phase 4 trial • 136 Patients • NCT03235739
1%
Troponin elevation and ST elevation
100%
80%
60%
40%
20%
0%
Study treatment Arm
Treatment-Naloxegol
Placebo Arm

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Treatment ArmExperimental Treatment1 Intervention
Naloxegol 25 mg given once in the morning every day until Post-operative Day 3 or day of discharge whichever occurs first
Group II: Placebo ArmPlacebo Group1 Intervention
Matching placebo given once in the morning every day until Post-operative Day 3 or day of discharge whichever occurs first
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Naloxegol 25 MG
2017
Completed Phase 4
~140

Find a Location

Who is running the clinical trial?

The Cleveland ClinicLead Sponsor
1,025 Previous Clinical Trials
1,365,740 Total Patients Enrolled
10 Trials studying Postoperative Pain
3,075 Patients Enrolled for Postoperative Pain
Mehmet A Turan, MDPrincipal InvestigatorThe Cleveland Clinic

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Ancillary Effects of Oral Naloxegol (Movantik)
Alparslan Turan 2017. "Ancillary Effects of Oral Naloxegol (Movantik)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03235739.
~18 spots leftby Apr 2025
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