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Local Anesthetic

articaine for Postoperative Pain

Phase 4
Waitlist Available
Led By Jayapriyaa Shanmugham, BDS MPH DrPH
Research Sponsored by Boston University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up tooth preparation occurs during the dental procedure.
Awards & highlights

Study Summary

This trial is testing whether articaine or lidocaine is more effective for lower teeth anesthesia in children. The study will use the same dentist for each child and compare the patient's comfort levels at different points during the procedure.

Eligible Conditions
  • Postoperative Pain
  • Dental Anesthesia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~pulp opening occurs during the dental procedure.
This trial's timeline: 3 weeks for screening, Varies for treatment, and pulp opening occurs during the dental procedure. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Pain during anesthesia injection using the Wong-Baker faces scale
Pain during pulp opening using the Wong-Baker faces scale
Pain during restoration placement using the Wong-Baker faces scale
+2 more
Secondary outcome measures
Additional injections of local anesthetic at the first visit
Additional injections of local anesthetic at the second visit

Trial Design

2Treatment groups
Experimental Treatment
Group I: lidocaine then articaineExperimental Treatment2 Interventions
For the first dental procedure 2% lidocaine with 1:100,000 epinephrine will be administered with a buccal infiltration injection followed by 2-3 interpapillary injections and possibly more if needed. For the second dental procedure a single buccal infiltration injection of 4% articaine with 1:100,000 epinephrine will be administered.
Group II: articaine then lidocaineExperimental Treatment2 Interventions
For the first dental procedure a single buccal infiltration injection of 4% articaine with 1:100,000 epinephrine will be administered. For the second dental procedure 2% lidocaine with 1:100,000 epinephrine will be administered with a buccal infiltration injection followed by 2-3 interpapillary injections and possibly more if needed.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
lidocaine
2005
Completed Phase 4
~1390
articaine
2009
Completed Phase 4
~20

Find a Location

Who is running the clinical trial?

Boston UniversityLead Sponsor
454 Previous Clinical Trials
9,941,570 Total Patients Enrolled
Jayapriyaa Shanmugham, BDS MPH DrPHPrincipal InvestigatorBU Henry M. Goldman School of Dental Medicine

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Articaine vs Lidocaine for Pediatric Dental Procedures
2022. "Articaine vs Lidocaine for Pediatric Dental Procedures". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03318952.
~0 spots leftby Apr 2025
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