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Local Anesthetic

Bupi HCl plus liposomal bupi for Post Operative Pain Management

Phase 4
Waitlist Available
Led By Andrej Alfirevic, MD
Research Sponsored by The Cleveland Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 72 hours postoperative
Awards & highlights

Study Summary

This trial will see if PECS/SAP blocks with liposomal bupivacaine can improve pain relief after surgery. They will compare it to just regular bupivacaine.

Eligible Conditions
  • Post Operative Pain Management

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~72 hours postoperative
This trial's timeline: 3 weeks for screening, Varies for treatment, and 72 hours postoperative for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Overall Benefit Analgesia Score
Secondary outcome measures
Cumulative Opioid Consumption Over Postoperative 3 Days
Postoperative FEV1
Postoperative FVC
+1 more

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Bupi HCl plus liposomal bupiActive Control2 Interventions
Pectoral fascial plane or serratus anterior plane blocks (PECSII/SAP blocks) with bupivacaine HCl plus liposomal bupivacaine. An ultrasound guided pectoral fascial plane blocks (PECS I and II blocks) and Serratus anterior plane (SAP) block with injection of the local anesthetic.
Group II: Control GroupPlacebo Group1 Intervention
Standard parenteral analgesia technique with or without incisional local anesthetic infiltration: patients randomized to control group will be given parenteral opioids (such as fentanyl or hydromorphone) until they are converted to the enteral medications such as Percocet.

Find a Location

Who is running the clinical trial?

The Cleveland ClinicLead Sponsor
1,030 Previous Clinical Trials
1,365,348 Total Patients Enrolled
1 Trials studying Post Operative Pain Management
102 Patients Enrolled for Post Operative Pain Management
Andrej Alfirevic, MDPrincipal InvestigatorThe Cleveland Clinic

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Pectoralis and Serratus Muscle Blocks
2021. "Pectoralis and Serratus Muscle Blocks". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03743194.
~63 spots leftby Apr 2025
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