← Back to Search

Oral Tranexamic Acid for Knee Replacement Recovery

Phase 4

Waitlist Available

Led By Marcus C Ford, MD

Research Sponsored by Campbell Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Primary total knee replacement in ambulatory setting

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up postoperative one year

Awards & highlights

Study Summary

This trial will compare the effects of tranexamic acid to a placebo on patients who have just had a total knee replacement.

Who is the study for?

This trial is for individuals undergoing primary total knee replacement who can walk, are willing to participate, will attend physical therapy at Campbell Clinic Wolf River, and understand English. It's not for those unwilling to join, with a history of cancer (except certain skin cancers), on pre-op anticoagulants other than low-dose aspirin, or with past thromboembolic events.Check my eligibility

What is being tested?

The study compares the effects of an oral tranexamic acid pill versus a placebo taken after knee replacement surgery. The goal is to see how each affects blood loss, pain levels post-surgery, and patient-reported outcomes.See study design

What are the potential side effects?

Tranexamic acid may cause side effects such as nausea or diarrhea. In rare cases it could increase the risk of blood clots; however specific side effects in this trial have not been listed.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I had a total knee replacement done as an outpatient.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ postoperative one year

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~postoperative one year

This trial's timeline: 3 weeks for screening, Varies for treatment, and postoperative one year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Hemoglobin level

Secondary outcome measures

KOOS Jr Score

Visual Analog Score

range of motion of knee

Other outcome measures

Incidence of treatment-emergent adverse event

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Oral TXAExperimental Treatment1 Intervention

1,950 mg oral tranexmic acid (three capsules of 650 mg) administered in post-anesthesia care, postop day one and postop day two. Compounded by registered pharmacist and labeled with subject name and instructions for use.

Group II: Oral placeboPlacebo Group1 Intervention

Three capsules of cellulose administered in post-anesthesia care, postop day one and postop day two. Compounded by registered pharmacist and labeled with subject name and instructions for use.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Campbell ClinicLead Sponsor

10 Previous Clinical Trials

1,776 Total Patients Enrolled

Marcus C Ford, MDPrincipal InvestigatorCampbell Clinic

Media Library

Placebo Clinical Trial Eligibility Overview. Trial Name: NCT05099276 — Phase 4

Osteoarthritis Research Study Groups: Oral TXA, Oral placebo

Osteoarthritis Clinical Trial 2023: Placebo Highlights & Side Effects. Trial Name: NCT05099276 — Phase 4

Placebo 2023 Treatment Timeline for Medical Study. Trial Name: NCT05099276 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How risky is the ingestion of Tranexamic Acid Pill for individuals?

"Data on Tranexamic Acid Pill's safety has been collected and reviewed, leading our team to rate its safety at a 3. This is because the treatment is already approved for clinical use."

Answered by AI

What is the aggregate amount of participants registered for this trial?

"Unfortunately, recruitment for this study has concluded. It was initially posted on December 7th 2021 and the last update was January 19th 2022. Currently, 937 trials related to pain management post-operatively are open for enrolment as well as 61 clinical studies involving Tranexamic Acid Pill treatment."

Answered by AI

Is admission to this experiment possible for me?

"In order to be included in this clinical trial, prospective participants must suffer from pain and have undergone a previous operation. The age limitation is set between eighteen and eighty years old, with only forty slots available for enrolment."

Answered by AI

Is enrollment for this clinical experiment still open?

"According to clinicaltrials.gov, this medical trial is not currently soliciting participants. The initial posting date was December 7th 2021 and the data on the site has been most recently updated January 19th 2022. Though it does not appear that patients are being recruited for this study at present, there are 998 other studies in progress looking for volunteers now."

Answered by AI

In what circumstances is Tranexamic Acid Pill typically administered?

"Tranexamic Acid Pill is typically used to treat hyperfibrinolysis, but has also been known to relieve patients with hemophilia, bleeding issues, and post-extraction bleeding."

Answered by AI

Has Tranexamic Acid Pill been experimentally tested in a medical context before?

"Currently, there are 61 Tranexamic Acid Pill studies in progress with 26 at the Phase 3 level. Although Kansas City, Kansas is a hub for research involving this medication, it can be found being conducted in 185 other clinical sites across the world."

Answered by AI