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Diazepam for Postoperative Pain

Phase 4
Waitlist Available
Led By Rachel Pauls, MD
Research Sponsored by TriHealth Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up between 3.5 and 6 hours postoperatively
Awards & highlights

Study Summary

This trial will study whether the use of rectal diazepam suppositories can decrease postoperative pain after major vaginal pelvic organ prolapse surgery.

Eligible Conditions
  • Postoperative Pain

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~between 3.5 and 6 hours postoperatively
This trial's timeline: 3 weeks for screening, Varies for treatment, and between 3.5 and 6 hours postoperatively for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Vaginal/Rectal pain in Visual Analogue Scale (VAS) score

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Diazepam groupExperimental Treatment1 Intervention
Rectal Diazepam suppository
Group II: Placebo groupPlacebo Group1 Intervention
Placebo suppository
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Diazepam
FDA approved

Find a Location

Who is running the clinical trial?

TriHealth Inc.Lead Sponsor
95 Previous Clinical Trials
50,838 Total Patients Enrolled
2 Trials studying Postoperative Pain
496 Patients Enrolled for Postoperative Pain
Rachel Pauls, MDPrincipal InvestigatorTriHealth - Cincinnati Urogynecology Associates
23 Previous Clinical Trials
25,885 Total Patients Enrolled
2 Trials studying Postoperative Pain
496 Patients Enrolled for Postoperative Pain

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
American Journal of Obstetrics and GynecologyJournal
Intrarectal Diazepam Following Pelvic Reconstructive Surgery: A Double-blind, Randomized Placebo-controlled Trial
Aldrich, Emily R., Tiffanie Y. Tam, Leah M. Saylor, Catrina C. Crisp, Jennifer Yeung, and Rachel N. Pauls. 2022. “Intrarectal Diazepam Following Pelvic Reconstructive Surgery: A Double-blind, Randomized Placebo-controlled Trial”. American Journal of Obstetrics and Gynecology. Elsevier BV. doi:10.1016/j.ajog.2022.05.009.
clinicaltrials.govStudy
Impact of Placement of a Diazepam Suppository on Early Postoperative Pain Following Pelvic Reconstructive Surgery
2020. "Impact of Placement of a Diazepam Suppository on Early Postoperative Pain Following Pelvic Reconstructive Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04198233.
~25 spots leftby Apr 2025
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