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Cephalosporin Antibiotic

anti-pseudomonal cephalosporin for Acute Kidney Injury (ACORN Trial)

Phase 4
Waitlist Available
Led By Edward T Qian, MD
Research Sponsored by Vanderbilt University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 14 days post-enrollment
Awards & highlights

ACORN Trial Summary

This trial will compare the effects of two different types of antibiotics on kidney function in people with sepsis.

Eligible Conditions
  • Acute Kidney Injury
  • Neurotoxicity
  • Sepsis

ACORN Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~14 days post-enrollment
This trial's timeline: 3 weeks for screening, Varies for treatment, and 14 days post-enrollment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Acute Kidney Injury (AKI) Ordinal Scale
Secondary outcome measures
Delirium and Coma-Free Days to Day 14
Major Adverse Kidney Events Within 14 Days (MAKE14)
Other outcome measures
Post-Emergency Department Disposition

ACORN Trial Design

2Treatment groups
Active Control
Group I: anti-pseudomonal cephalosporinActive Control1 Intervention
Participants in the anti-pseudomonal cephalosporin arm will receive at least one dose of an anti-pseudomonal cephalosporin.
Group II: anti-pseudomonal penicillinActive Control1 Intervention
Participants in the anti-pseudomonal penicillin arm will receive at least one dose of an anti-pseudomonal penicillin.

Find a Location

Who is running the clinical trial?

Vanderbilt University Medical CenterLead Sponsor
857 Previous Clinical Trials
669,559 Total Patients Enrolled
4 Trials studying Acute Kidney Injury
13,001 Patients Enrolled for Acute Kidney Injury
Edward T Qian, MDPrincipal InvestigatorVanderbilt University Medical Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Plos OneJournal
Effect of Performance Improvement Programs on Compliance with Sepsis Bundles and Mortality: A Systematic Review and Meta-analysis of Observational Studies
Damiani, Elisa, Abele Donati, Giulia Serafini, Laura Rinaldi, Erica Adrario, Paolo Pelaia, Stefano Busani, and Massimo Girardis. 2015. “Effect of Performance Improvement Programs on Compliance with Sepsis Bundles and Mortality: A Systematic Review and Meta-analysis of Observational Studies”. Edited by Philip Alexander Efron. Plos One. Public Library of Science (PLoS). doi:10.1371/journal.pone.0125827.
International Journal of Antimicrobial AgentsJournal
Acute Kidney Injury with Combination Vancomycin and Piperacillin-tazobactam Therapy in the ICU: A Retrospective Cohort Study
O'Callaghan, Kevin, Karen Hay, Jayshree Lavana, and John F McNamara. 2020. “Acute Kidney Injury with Combination Vancomycin and Piperacillin-tazobactam Therapy in the ICU: A Retrospective Cohort Study”. International Journal of Antimicrobial Agents. Elsevier BV. doi:10.1016/j.ijantimicag.2020.106010.
Journal of Critical CareJournal
Comparison of Acute Kidney Injury Risk Associated with Vancomycin and Concomitant Piperacillin/tazobactam or Cefepime in the Intensive Care Unit
Buckley, Mitchell S., Nicole C. Hartsock, Andrew J. Berry, Dale S. Bikin, Emily C. Richards, Melanie J. Yerondopoulos, Emir Kobic, Laura M. Wicks, and Drayton A. Hammond. 2018. “Comparison of Acute Kidney Injury Risk Associated with Vancomycin and Concomitant Piperacillin/tazobactam or Cefepime in the Intensive Care Unit”. Journal of Critical Care. Elsevier BV. doi:10.1016/j.jcrc.2018.08.007.
Critical Care MedicineJournal
Incidence and Outcomes of Acute Kidney Injury in Intensive Care Units: A Veterans Administration Study*
Thakar, Charuhas V., Annette Christianson, Ron Freyberg, Peter Almenoff, and Marta L. Render. 2009. “Incidence and Outcomes of Acute Kidney Injury in Intensive Care Units: A Veterans Administration Study*”. Critical Care Medicine. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/ccm.0b013e3181a5906f.
~771 spots leftby Apr 2025
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