Anesthesia Choice for Gynecologic Cancer Surgery
Trial Summary
What is the purpose of this trial?
Steep Trendelenburg positioning and insufflation of the abdominal cavity have shown to increase intra ocular pressure. Different anesthetic techniques can alter intra ocular pressure and a small pilot study showed decrease in Intraocular Pressure (IOP) in robotic case in steep Trendelenburg with IV anesthetics (TIVA). We want to quantify the degree of change in Intraocular Pressure (IOP) in female patients undergoing robotic procedures for cancer. We want to detect the difference in increase of pressure with total IV anesthesia versus conventional balanced anesthesia
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Balanced anesthesia, General anesthesia, Conventional anesthesia, TIVA, Total Intravenous Anesthesia, Propofol-based anesthesia for gynecologic cancer surgery?
Is propofol-based total intravenous anesthesia (TIVA) safe for use in humans?
Propofol-based total intravenous anesthesia (TIVA) has been studied in various cancer surgeries and is generally considered safe for use in humans. The research primarily focuses on comparing its effectiveness and long-term outcomes with inhalation anesthesia, but no significant safety concerns have been highlighted in these studies.12345
How does the anesthesia treatment for gynecologic cancer surgery differ from other treatments?
The treatment uses propofol-based total intravenous anesthesia (TIVA), which has been associated with better survival outcomes compared to inhalation anesthesia in various cancer surgeries, including ovarian cancer. This approach may lead to improved long-term survival and reduced recurrence and metastasis after surgery.12456
Research Team
Sonia Mehta, MD
Principal Investigator
University of Florida
Eligibility Criteria
This trial is for women over 18 who are set to have robotic surgery for suspected or confirmed gynecological cancer. They must be cleared by the pre-anesthesia clinic and agree to all study procedures. It's not open to those with certain eye conditions, recent eye surgery, or known high intraocular pressure.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Day of Surgery
Intraocular Pressure (IOP) is measured at multiple time points during the surgical procedure using different anesthetic techniques
Post-operative Monitoring
Post-operative IOP measurements are taken, and any abnormal readings prompt an ophthalmology consult
Follow-up
Participants are monitored for any ongoing ocular issues and effectiveness of the anesthetic techniques
Treatment Details
Interventions
- Balanced anesthesia
- TIVA
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Florida
Lead Sponsor