Bronchoscopy for Cancer
Trial Summary
What is the purpose of this trial?
This is a single-centre, Phase II, prospective study designed to assess BALF and TA-derived biomarkers in relation to metastatic burden in STS patients. BALF and TA samples will be collected during routine bronchoscopy performed as part of standard care at Toronto General Hospital (TGH). Additionally, tissue samples of lung metastases and adjacent normal lung will be collected and used to correlate the identified biomarkers.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of the treatment Bronchoscopy, Metastasectomy for cancer?
Metastasectomy, which involves surgically removing cancer that has spread to the lungs, can be the only curative option for some patients and may improve survival if the cancer is completely removed. Bronchoscopy, a procedure to look inside the lungs, is valuable for diagnosing lung metastases, especially in certain types of cancer like colorectal and breast cancer.12345
Is bronchoscopy generally safe for humans?
Bronchoscopy is generally considered a safe procedure, but complications can occur, such as pneumothorax (collapsed lung), bleeding, and in rare cases, death. Safety data from various studies suggest that while it is safe for many patients, certain conditions or trainee involvement may increase the risk of complications.678910
How is bronchoscopy used in cancer treatment different from other treatments?
Bronchoscopy is a unique treatment for cancer as it is a minimally invasive procedure that allows doctors to directly view the airways and collect samples for diagnosis, particularly useful for detecting lung metastases. Unlike other treatments that may rely on imaging or systemic therapies, bronchoscopy provides direct access to the lung tissue, making it valuable for diagnosing and managing metastatic lung tumors.34111213
Eligibility Criteria
This trial is for patients with sarcoma, a type of cancer that may spread to the lungs. Participants must be undergoing routine bronchoscopy at Toronto General Hospital as part of their standard care and can provide tissue samples from lung metastases.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Sample Collection
BALF and TA samples are collected during routine bronchoscopy and standard of care metastasectomy
Analysis
Comprehensive multi-omic analysis of collected specimens to characterize molecular landscape and identify biomarkers
Follow-up
Participants are monitored for safety and effectiveness after sample collection and analysis
Treatment Details
Interventions
- Bronchoscopy
- Metastasectomy
Find a Clinic Near You
Who Is Running the Clinical Trial?
University Health Network, Toronto
Lead Sponsor