← Back to Search

Opioid Analgesic

Morphine, Duloxetine for Chronic Lower Back Pain (Duloxetine Trial)

Phase 4
Waitlist Available
Led By Jianren Mao, MD, PhD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 10 weeks
Awards & highlights

Duloxetine Trial Summary

This trial is testing whether a drug called duloxetine can help reduce pain and the amount of opioids used when treating pain.

Eligible Conditions
  • Chronic Lower Back Pain
  • Chronic Neck Pain

Duloxetine Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~10 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 10 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Overall Opioid Dose
Visual Analog Scale (VAS)

Duloxetine Trial Design

3Treatment groups
Active Control
Placebo Group
Group I: Morphine, DuloxetineActive Control2 Interventions
Subjects will take a maximum dose of 60 mg/day of extended release morphine capsules and 60 mg of duloxetine capsules.
Group II: Morphine, Placebo DuloxetinePlacebo Group2 Interventions
Subjects will take a maximum dose of 60 mg/day of extended release morphine capsules and placebo duloxetine capsules.
Group III: Placebo Morphine, DuloxetinePlacebo Group2 Interventions
Subjects will take placebo morphine capsules and 60 mg of duloxetine capsules.

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,925 Previous Clinical Trials
13,197,823 Total Patients Enrolled
Jianren Mao, MD, PhDPrincipal Investigator - Massachusetts General Hospital
Massachusetts Eye & Ear Infirmary, Massachusetts General Hospital, Shriners Hospitals for Children-Boston
Suzhou Medical College (Medical School)
Mass Gen Hospital (Residency)

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Effect of Combined Morphine and Duloxetine on Chronic Pain
Jianren Mao, MD, PhD 2018. "Effect of Combined Morphine and Duloxetine on Chronic Pain". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03249558.
~11 spots leftby Apr 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top