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Antiplatelet Agent

Clopidogrel for Myocardial Ischemia

Phase 4
Waitlist Available
Led By Joshua P Lewis, PhD
Research Sponsored by University of Maryland, Baltimore
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Of Old Order Amish descent
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measured at baseline and after 8 days of clopidogrel treatment
Awards & highlights

Study Summary

This trial is looking at how well a blood-thinning medication works in people with a certain gene.

Eligible Conditions
  • Myocardial Ischemia
  • Aspirin Sensitivity
  • Cardiovascular Disease
  • Platelet Thrombus
  • Coronary Artery Disease
  • Thrombocytopenia
  • Artery Blockage
  • Coronary Heart Disease
  • Heart Disease
  • Clopidogrel Syndrome

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You are of Amish descent.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~measured at baseline and after 8 days clopidogrel administration plus 1 day of aspirin treatment
This trial's timeline: 3 weeks for screening, Varies for treatment, and measured at baseline and after 8 days clopidogrel administration plus 1 day of aspirin treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Changes in Platelet Function in Response to Clopidogrel
Changes in Platelet Function in Response to Clopidogrel Plus Aspirin

Trial Design

1Treatment groups
Experimental Treatment
Group I: Overall CohortExperimental Treatment2 Interventions
Participants will receive clopidogrel treatment alone (300 mg loading dose followed by 75 mg/d for 6 days), followed by clopidogrel (75 mg) plus aspirin (324 mg) treatment on day 8.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Clopidogrel
2010
Completed Phase 4
~9160
Aspirin
2014
Completed Phase 4
~55580

Find a Location

Who is running the clinical trial?

University of Maryland, BaltimoreLead Sponsor
687 Previous Clinical Trials
374,640 Total Patients Enrolled
2 Trials studying Myocardial Ischemia
712 Patients Enrolled for Myocardial Ischemia
Joshua P Lewis, PhDPrincipal InvestigatorUniversity of Maryland
2 Previous Clinical Trials
289 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has Clopidogrel been utilized in other scientific investigations?

"Currently, 191 clinical trials centred around Clopidogrel are taking place with 53 of those studies in Phase 3. Active research sites for this medication are based primarily in New Orleans, Louisiana but can be found at over 4000 locations worldwide."

Answered by AI

Is this research a pioneering endeavor?

"Since its initial clinical trial sponsored by Abbott in 2005, which involved 15480 patients, Clopidogrel has been subject to numerous studies. This research eventually led it to receive Phase 4 drug approval and today there are 191 active trials taking place across 1410 cities and 57 countries."

Answered by AI

What is the current enrollment of this clinical investigation?

"This study is no longer actively recruiting participants. The trial was first listed on October 14th, 2019 and last adjusted on January 24th 2022. Currently, there are 1,461 trials searching for patient suffering from myocardial ischemia and 191 studies in pursuit of Clopidogrel users to take part in their research."

Answered by AI

Is this research initiative currently enlisting new participants?

"Data posted to clinicaltrials.gov affirms that this medical trial is not currently accepting new patients; it was first published on October 14th 2019 and its last update occurred in January 24th 2022. Despite this, 1652 other trials are actively recruiting participants at present."

Answered by AI

What medical conditions commonly necessitate the use of Clopidogrel?

"Clopidogrel is commonly prescribed to treat stroke, Peripheral Arterial Disease (PAD), death by myocardial infarction and other symptoms."

Answered by AI

To what extent could Clopidogrel be detrimental to individuals' health?

"Clinical data and extensive testing in prior phases has proven Clopidogrel to be safe, thus receiving a score of 3."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
CES1 Carriers in the PAPI Study
Joshua Lewis 2019. "CES1 Carriers in the PAPI Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03188705.
~1 spots leftby Apr 2025
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