Apply to Trial

Compensation: Varies

Number of Visits: 1

Duration: 3 months

94 Participants Needed

JUVÉDERM Products for Midface Volume Loss

Recruiting at 7 trial locations

Overseen ByABBVIE CALL CENTER

Age: 18+

Sex: Any

Trial Phase: Phase 4

Sponsor: AbbVie

Disqualifiers: Non-permanent fillers, Loose skin, Scarring, others

No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests the safety and effectiveness of different JUVÉDERM products to improve facial volume and skin quality. JUVÉDERM, a type of filler, can make areas like the cheeks, lips, and chin appear fuller and smoother. Suitable candidates for this trial often feel their face looks less full or sags, particularly around the cheeks, jawline, or lips. Participants should be in good health and should not have received similar treatments in the past year. As a Phase 4 trial, this research involves an FDA-approved treatment, aiming to understand its benefits for more patients.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial organizers or your doctor.

What is the safety track record for these JUVÉDERM treatments?

A previous study found JUVÉDERM products to be generally well-tolerated for restoring facial volume and improving skin quality. These treatments use hyaluronic acid, a substance naturally found in the body, to smooth wrinkles and add volume.

The FDA has approved JUVÉDERM VOLUMA XC for treating temple hollowing, confirming its safety for that purpose. SKINVIVE by JUVÉDERM also holds FDA approval for improving cheek smoothness, further supporting its safety.

Most people using JUVÉDERM products experience only minor side effects, such as swelling or redness at the injection site. These effects typically resolve on their own. The products have been widely used and are considered safe for cosmetic treatments.¹ ² ³ ⁴ ⁵

Why are researchers enthusiastic about this study treatment?

Researchers are excited about JUVÉDERM products for midface volume loss because they offer a more customizable and potentially longer-lasting solution compared to traditional fillers. Unlike standard options that often require frequent touch-ups, JUVÉDERM products use advanced hyaluronic acid formulations designed to provide natural-looking volume with improved longevity. Additionally, the variety of products like VOLUMA XC and VOLUX XC allows for tailored treatment plans, addressing specific needs and achieving desired aesthetic outcomes more precisely.

What evidence suggests that JUVÉDERM products are effective for midface volume loss?

Research has shown that JUVÉDERM products effectively treat facial volume loss. In this trial, participants will receive at least two JUVÉDERM products for at least three indications, with specific products and indications determined by the investigator. JUVÉDERM VOLUMA XC adds volume to the cheeks and improves the appearance of the chin. Studies have found that JUVÉDERM ULTRA XC fills deeper wrinkles and enhances lip fullness. These fillers contain hyaluronic acid, a natural substance in the skin, to create a fuller, smoother appearance. JUVÉDERM products are widely used and trusted for enhancing facial volume and reducing wrinkles.⁴ ⁶ ⁷ ⁸ ⁹

Who Is on the Research Team?

ABBVIE INC.

Principal Investigator

AbbVie

Are You a Good Fit for This Trial?

Adults with varying degrees of facial volume loss who wish to improve their facial appearance can join this trial. They must have specific levels of hollowing, wrinkles, or folds according to Allergan's scales and be in good health as determined by medical history and exams.

Inclusion Criteria

My mid-face area has moderate to severe volume loss.

My nasolabial fold severity is moderate to severe.

My chin retrusion is moderate to severe according to the ACRS.

See 6 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive at least 2 JUVÉDERM products for at least 3 indications at Treatment Visit 1

3 months

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

3 months

What Are the Treatments Tested in This Trial?

Interventions

JUVÉDERM ULTRA PLUS XC
JUVÉDERM ULTRA XC
JUVÉDERM VOLBELLA XC
JUVÉDERM VOLLURE XC
JUVÉDERM VOLUMA XC
JUVÉDERM VOLUX XC
SKINVIVE by JUVÉDERM

Trial Overview The study is testing the safety and effectiveness of various JUVÉDERM products like VOLUX XC, VOLUMA XC, VOLBELLA XC, VOLLURE XC, SKINVIVE by JUVÉDERM, ULTRA XC, and ULTRA PLUS XC for enhancing facial volume and skin quality.

How Is the Trial Designed?

1Treatment groups

Experimental Treatment

Group I: Open-Label JUVÉDERMExperimental Treatment7 Interventions

Participants will receive at least 2 JUVÉDERM products for at least 3 indications (specific products and indications will be at the discretion of the investigator and per participant eligibility criteria) at Treatment Visit 1.

Find a Clinic Near You

Who Is Running the Clinical Trial?

AbbVie

Lead Sponsor

Trials

1,079

Recruited

535,000+

Founded

2013

Headquarters

North Chicago, USA

Known For

Immunology treatments

Citations

1.hcp.juvederm.comhcp.juvederm.com/

Collection of Dermal Fillers | JUVÉDERM® OfficialJUVEDERM® Collection of Fillers is the #1 chosen dermal filler collection worldwide. Specifically designed to meet your patients' needs.

2.skinlab-nyc.comskinlab-nyc.com/blog/which-filler-is-right-for-you/

Juvederm, Restylane, RHA Fillers: Which is Right for You?The Juvederm Filler lineup includes: Juvederm Ultra XC: Great for adding volume to the lips and addressing moderate to severe facial wrinkles.

3.heartlandplastic.comheartlandplastic.com/which-type-of-juvederm-is-right-for-you/

Which Type of Juvederm is Right for You? - Heart LandJuvéderm Ultra XC is best for use on moderate to severe wrinkles and to fill out deeper nasolabial folds. It is also suitable for creating plump lips or fuller ...

4.puremedicalspa.uspuremedicalspa.us/all-types-of-juvederm-filler-a-complete-guide-to-enhancing-your-look/

Types of Juvéderm Filler | A Complete Guide to Enhancing ...Juvéderm is a hyaluronic acid (HA)-based dermal filler designed to restore volume, smooth wrinkles, and enhance facial features.

5.atallamd.comatallamd.com/juvederm-ultra-plus-xc/

Juvéderm® Ultra Plus XC - Bowling GreenJUVÉDERM® VOLUMA® XC is for deep injection in the cheek area to correct age-related volume loss and for augmentation of the chin region to improve the chin ...

6.juvederm.comjuvederm.com/treatment-areas

Juvederm Treatment Areas | JUVÉDERM® OfficialJUVÉDERM® VOLUX® XC injectable gel is for deep injection to improve moderate to severe loss of jawline definition in adults over the age of 21. JUVÉDERM® ...

7.dermablue.comdermablue.com/cosmetic-skin-care/dermal-fillers/ultra-plus-xc/

JUVÉDERM® Ultra Plus XC FillerJUVÉDERM Ultra Plus XC is a hyaluronic acid filler that helps treat wrinkles and folds in a variety of areas around the mid face.

8.news.abbvie.comnews.abbvie.com/2024-10-02-Available-Nationwide-JUVEDERM-R-VOLUMA-R-XC-for-Moderate-to-Severe-Temple-Hollowing

Available Nationwide: JUVÉDERM® VOLUMA® XC for ...Following its U.S. FDA approval in March 2024, JUVÉDERM® VOLUMA® XC is the first and only hyaluronic acid (HA) filler approved to treat moderate ...

9.allerganaesthetics.comallerganaesthetics.com/brands/skinvive

SKINVIVESKINVIVE™ by JUVÉDERM® is the first and only FDA-approved hyaluronic acid (HA) microdroplet injectable in the US to improve skin smoothness of the cheeks.

Other People Viewed

By Subject

By Trial