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High Blood Pressure Drug for Lupus-Related Heart Disease

Phase 4

Waitlist Available

Research Sponsored by University Health Network, Toronto

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients >20 years with Lupus according to ACR criteria

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 years

Awards & highlights

Study Summary

This trial is investigating whether a common drug used to treat high blood pressure could also help treat an autoimmune disease that mainly affects women. The disease, lupus, can cause damage to the heart, and this trial is looking at whether the drug can help improve heart function in patients with lupus.

Who is the study for?

This trial is for adults over 20 with Systemic Lupus Erythematosus (SLE) who show abnormal heart muscle blood flow but no major artery blockages. It's not for those allergic to certain stress test drugs, with steroid-dependent asthma, a history of swelling under the skin, kidney artery narrowing, high serum creatinine levels, or pregnant/breastfeeding women. Also excluded are those unable to do light exercise or currently on ACE inhibitors/ARBs/nitrates.Check my eligibility

What is being tested?

The study investigates if endothelial dysfunction (blood vessel issues) contributes to heart disease in SLE patients by measuring blood vessel dilation and comparing it with heart perfusion and SLE activity. Some will undergo angiography. The trial also tests whether Quinapril (an ACE inhibitor) can improve these conditions versus a placebo in a crossover design where participants switch treatments midway.See study design

What are the potential side effects?

Quinapril may cause coughing, dizziness due to low blood pressure, kidney problems, elevated blood potassium levels which can affect the heart rhythm and rarely angioedema (swelling beneath the skin). Side effects often vary between individuals.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am over 20 years old and have been diagnosed with Lupus.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Heart and Stroke Foundation of CanadaOTHER

122 Previous Clinical Trials

72,056 Total Patients Enrolled

University Health Network, TorontoLead Sponsor

1,468 Previous Clinical Trials

484,469 Total Patients Enrolled

Robert M Iwanochko, MDStudy DirectorUniversity Health Network, Toronto

Media Library

Treatment Clinical Trial Eligibility Overview. Trial Name: NCT00188188 — Phase 4

Lupus Clinical Trial 2023: Treatment Highlights & Side Effects. Trial Name: NCT00188188 — Phase 4

Treatment 2023 Treatment Timeline for Medical Study. Trial Name: NCT00188188 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is my profile compatible with the requirements to partake in this research?

"In order to be a part of this medical trial, individuals must have systemic lupus erythematosus and fall between the ages of 20 and 0. Approximately 50 patients are expected to participate in total."

Answered by AI

Is the potential risk of this treatment sufficient to outweigh its efficacy?

"Our team has evaluated the safety of this therapy and concluded that it warrants a rating of 3, as Phase 4 trials are generally approved treatments."

Answered by AI

Does this trial permit the enrolment of participants aged thirty and above?

"This study only allows for participants between the ages of 20 and 0. For those outside this range, there are 18 trials intended for minors and 106 geared towards seniors."

Answered by AI

Are there any available slots for enrolment in this medical experiment?

"As per clinicaltrials.gov, this medical trial is not presently accepting patients; it was first posted on March 1st 2002 and last updated December 28th 2005. Despite the inactivity of this study, 124 other trials are still currently enrolling participants."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Study of Endothelial Dysfunction in Systemic Lupus and Its Role in Heart Disease

2002. "Study of Endothelial Dysfunction in Systemic Lupus and Its Role in Heart Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00188188.

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