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Platelet Rich Plasma Joint Injection for Sacroiliitis

Phase 4
Waitlist Available
Led By Douglas Hemler, MD
Research Sponsored by Star Spine and Sport
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline compared to 6 months post injection
Awards & highlights

Study Summary

This prospective study will be quantitatively analyzing the effectiveness of platelet-rich-plasma (PRP) injections into the sacroiliac (SI) joint in relieving sacroiliitis and low back pain originating from the SI joint. The effectiveness of PRP injections on joint pain has been well studied in the knee and shoulder. PRP injections are performed on the SI joint commonly, but there is little research documenting their effectiveness when compared to other interventions. This study will be a small pilot study to aid in closing this knowledge gap. Additionally, these injections will be performed under ultrasound guidance. Ultrasound has been proven to be of equal reliability to fluoroscopy and has the advantage of shorter time to administer and no radiation. There will be one arm to this study. The data collected will be compared to existing studies on corticosteroid SI joint injection. The experimental arm consists of the PRP injection. The PRP will be injected into the joint using the exact same technique via physical exam, special tests, and ultrasound guidance as performed in our previous studies. The outcomes will be measured with the Numeric Rating Scale for Pain (NRS) and the Oswestry Disability Index (ODI) prior to the injection, immediately post-injection, 2 weeks, 4 weeks, 3 months, and 6 months post-injection. The investigators hypothesis is, "Platelet-Rich Plasma Injections in the Sacroiliac Joint using ultrasonography in conjunction with physical examination and Point of Maximal Tenderness will produce statistically significant pain relief for more than 3 months as measured by the Numeric Rating Scale for Pain (NRS) and Oswestry Disability Index (ODI)."

Eligible Conditions
  • Sacroiliitis
  • Chronic Lower Back Pain
  • Sacroiliac Pain
  • Platelet Rich Plasma
  • Platelets
  • Injection Site
  • Ultrasound Therapy Complications
  • Treatment

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline compared to 6 months post injection
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline compared to 6 months post injection for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Numeric Rating Scale for Pain (NRS)
Oswestry Disability Index (ODI)

Trial Design

1Treatment groups
Experimental Treatment
Group I: Platelet Rich Plasma Joint InjectionExperimental Treatment1 Intervention
Venous blood will be drawn from the patient receiving injection treatment. It will be spun down to form PRP and reinjected back into the SI joint.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Platelet Rich Plasma Joint Injection
2017
Completed Phase 4
~60

Find a Location

Who is running the clinical trial?

Star Spine and SportLead Sponsor
Douglas Hemler, MDPrincipal InvestigatorStar Spine and Sport, Rocky Vista University College of Osteopathic Medicine

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
Illinois
How old are they?
18 - 65
What site did they apply to?
Star Spine and Sport
What portion of applicants met pre-screening criteria?
Met criteria
~6 spots leftby Apr 2025