The pain may be sudden or progressive. Most commonly back pain is caused by soft tissue injury or nerve compression such as from a herniated disc. Low back pain can be caused by a dislocated vertebra, bone tumour, cancer, spinal infection, a torn ligament or muscle injury. Severe neck pain can be due to disc displacement or spinal cord compression. Pain intensity may vary with activity, posture and position. Pain may be experienced along one side of the back (lateralization) or be distributed all the way down the back (generalized pain). Low back pain may lead to a lack of motion, stiffness in the lumbar, back, shoulders and neck with or without weakness.
The most common treatment for back pain is over-the-counter medication. For those who have sciatica, steroids have a low level of evidence and are recommended only if other treatments have failed. For those with no sciatica, analgesics are not recommended unless they are necessary for other medical reasons.
Back pain is a common complaint in the UK and accounts for a lot of NHS resource usage, but is often ignored or treated with ineffective treatment or overtreatment. Effective pain management is important.\n\n- "
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There is no scientifically acceptable evidence to support the idea that one can cure back pain. It may be true that back pain is not medically incurable, but a successful treatment of back pain only confirms that the current medical condition is not one that can be cured. This should not be taken to imply that back pain is incurable; and that one can only experience worsening and recovery. It is possible to get better. However, with back pain it is important that a holistic view and treatment is taken in order that one may still be able to live a full life with a good quality of life and a normal life expectancy, and that a cure is not necessarily expected.
Nearly 7 million people will have back pain in 2012. By age 20, more than 33% of individuals will report back pain when they are measured by age 70. Because of the high degree of co-occurrence of back pain and other chronic low back disorders, primary physicians may wish to screen patients for a history and physical examination of other chronic musculoskeletal conditions before diagnosing and treating back pain. The burden of chronic low back pain is particularly significant because it can exacerbate preexisting chronic musculoskeletal conditions - particularly those of the knee.
The most prevalent causes of [back pain](https://www.withpower.com/clinical-trials/back-pain) in primary care settings are pain caused by disc disorders (31%). Nociceptive back pain can also be caused by muscle pain, which often occurs during activities related to occupational tasks (32%). Spinal disk disorders caused by trauma are also the most common cause of back pain in primary care settings (16%). Low back pain is associated with increased stress and physical inactivity, while moderate back pain occurs with a variety of other factors including physical activities, work tasks, and psychological factors.
It is now widely accepted that no single therapeutic modality is effective and safe in the treatment of all types of back pain. Current research is beginning to identify treatments that are particularly effective in certain subgroups of patients. Such research may help make it more economical to use existing treatments.
Eplerenone has no significant beneficial effect in reducing the duration of low back pain in post coronary surgery patients. Eplerenone is well prescribed but there is no evidence that it is effective.
Eplerenone 50 mg tab was found to be well tolerated in Japanese patients with stable angina pectoris, while no clinical benefit was observed when it was added to aspirin.
A strong heritability of back pain in children and adults has been proposed. This heritability could be attributed to many factors including genetic predisposition, and environmental factors at puberty and adolescence.
Eplerenone 50 mg, taken twice daily, is well tolerated in patients with [back pain](https://www.withpower.com/clinical-trials/back-pain) and decreases pain by an average of 3.5 cm on the VAS, a statistically significant change of 30%.
Eplerenone 50 mg tab is effective in reducing BNP and improving symptoms of CHF in patients with moderate-to-severe NYHA Class III or greater HF and LV ejection fraction <45 %.