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Eplerenone 50 Mg Tab for Lower Back Pain

Phase 4
Waitlist Available
Led By Timothy J Burroughs, MD
Research Sponsored by University of Cincinnati
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up difference between score prior to and 4 weeks after epidural steroid injection
Awards & highlights

Study Summary

This trial will test whether the addition of a drug that blocks the mineralocorticoid receptor can improve the efficacy of epidural steroid injections for low back pain.

Eligible Conditions
  • Lower Back Pain
  • Degenerative Disc Disease
  • Sciatica

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~difference between score prior to and 4 weeks after epidural steroid injection
This trial's timeline: 3 weeks for screening, Varies for treatment, and difference between score prior to and 4 weeks after epidural steroid injection for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
change in Oswestry Low Back Pain Disability Questionnaire at 12 months
Secondary outcome measures
change in Oswestry Low Back Pain Disability Questionnaire at 3 months
change in Oswestry Low Back Pain Disability Questionnaire at 4 weeks
change in Oswestry Low Back Pain Disability Questionnaire at 6 months
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: ExperimentalExperimental Treatment1 Intervention
Eplerenone 50 Mg Tab
Group II: ControlPlacebo Group1 Intervention
Placebo Oral Tablet

Find a Location

Who is running the clinical trial?

University of CincinnatiLead Sponsor
428 Previous Clinical Trials
634,386 Total Patients Enrolled
Timothy J Burroughs, MDPrincipal InvestigatorUniversity of Cincinnati
Shuchita Garg, MDPrincipal InvestigatorUniversity of Cincinnati

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is registration open for this experiment?

"According to clinicaltrials.gov, this investigation is actively recruiting participants. This experiment was initially posted on the 1st of July 2022 and most recently revised on the 19th of May 2022."

Answered by AI

How many people are currently enrolled in this clinical experiment?

"Affirmative. Clinicaltrials.gov attests that this research endeavour, which was initially announced on July 1st 2022, is actively recruiting participants. The current goal of the study is to enroll 40 people from 4 different sites."

Answered by AI

What therapeutic applications has Eplerenone 50 Mg Tab been associated with?

"Patients with lvef <40%, congestive heart failure, hypertensive disease, and hypesthesia can all be managed using Eplerenone 50 Mg Tab."

Answered by AI

Does this trial accommodate geriatric patients?

"Individuals aged 18 to 65 are eligible for this medical trial, while those younger than 18 and older than 65 can apply to 15 other studies and 359 others respectively."

Answered by AI

What criteria must a prospective participant meet to be eligible for this trial?

"This medical trial is aiming to enrol 40 individuals with lower back pain, aged between 18 and 65. To be eligible for the study, patients must verify they have a lumbar degenerative disc disease shown by an X-Ray or MRI scan; display radiating nerve symptoms according to electromyograph results; present exam findings that correspond to this diagnosis; be scheduled for lumbar epidural steroid injection as part of their clinical care plan; and if applicable provide proof of not being pregnant."

Answered by AI

Are there any dangers associated with an Eplerenone 50 Mg Tab regimen?

"The safety of Eplerenone 50 Mg Tab was rated a 3 due to the completion of Phase 4 trials, confirming its effectiveness and clearance for use."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Eplerenone as a Supplement to Epidural Steroid Injections
Shuchita Garg 2023. "Eplerenone as a Supplement to Epidural Steroid Injections". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03418649.
~0 spots leftby Dec 2025
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