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Antibiotic

Ceftriaxone for Liver Cirrhosis

Phase 4
Waitlist Available
Led By Zachary P Fricker, MD
Research Sponsored by Beth Israel Deaconess Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up once at time of randomization
Awards & highlights

Study Summary

This trial will assess the feasibility of a larger study investigating whether antibiotics can help patients with advanced cirrhosis who are admitted to the hospital.

Eligible Conditions
  • Liver Cirrhosis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Infections
Secondary outcome measures
30-day Mortality
Length of Stay
Mortality
Other outcome measures
Biomarker of Infection
Fungal Infection
Incident ACLF
+3 more

Side effects data

From 2021 Phase 4 trial • 32 Patients • NCT04218695
12%
Decompensated cirrhosis
6%
Rectus sheath hematoma
6%
hyperkalemia
6%
Possible gastrointestinal bleed
6%
Hepatic Failure
6%
Pruritus with rash
6%
Hepatic Encephalopathy
6%
Nausea
6%
UTI
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo
Treatment

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: TreatmentExperimental Treatment1 Intervention
1 gram intravenous ceftriaxone once daily for up to one week or until end of hospitalization
Group II: PlaceboPlacebo Group1 Intervention
Normal saline (50cc) once daily for up to one week or until end of hospitalization
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ceftriaxone
FDA approved

Find a Location

Who is running the clinical trial?

Beth Israel Deaconess Medical CenterLead Sponsor
837 Previous Clinical Trials
13,010,240 Total Patients Enrolled
1 Trials studying Liver Cirrhosis
549 Patients Enrolled for Liver Cirrhosis
American Association for the Study of Liver Diseases FoundationUNKNOWN
Zachary P Fricker, MDPrincipal InvestigatorBeth Israel Deaconess Medical Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Prophylactic Antibiotics in Admitted Cirrhotics
Zachary Fricker 2020. "Prophylactic Antibiotics in Admitted Cirrhotics". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04218695.
~7 spots leftby Apr 2025
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