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Antioxidant

MitoQ for Chronic Kidney Disease

Phase 4
Waitlist Available
Led By David G Edwards, PhD
Research Sponsored by University of Delaware
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Stage 3 - 5 Chronic Kidney Disease
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline at 4 weeks
Awards & highlights

Study Summary

The purpose of this study is to examine the effect of mitochondria derived oxidative stress on vascular function in patients with moderate to severe Chronic Kidney Disease.

Eligible Conditions
  • Chronic Kidney Disease

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline at 4 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline at 4 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Microvascular Function, assessed by laser Doppler flowmetry coupled with microdialysis
Secondary outcome measures
Conduit artery endothelial dependent dilation, assessed by duplex ultrasound
Mitochondria derived superoxide, assessed by electron paramagnetic resonance spectroscopy
Other outcome measures
Ambulatory Blood Pressure
Arterial Stiffness, assessed by central blood pressure, augmentation index and carotid artery to femoral artery pulse wave velocity
Endothelial cell NADPH oxidase expression
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: MitoQExperimental Treatment1 Intervention
4 week 20mg oral daily dose of MitoQ
Group II: PlaceboPlacebo Group1 Intervention
4 week 20mg oral daily placebo
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
MitoQ
2006
Completed Phase 2
~230

Find a Location

Who is running the clinical trial?

University of DelawareLead Sponsor
154 Previous Clinical Trials
25,187 Total Patients Enrolled
David G Edwards, PhDPrincipal InvestigatorUniversity of Delaware
3 Previous Clinical Trials
195 Total Patients Enrolled
Danielle L Kirkman, PhDPrincipal InvestigatorUniversity of Delaware
1 Previous Clinical Trials
25 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Mitochondrial Oxidative Stress and Vascular Health in Chronic Kidney Disease
David Edwards 2017. "Mitochondrial Oxidative Stress and Vascular Health in Chronic Kidney Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02364648.
All > Chronic Kidney Disease
~3 spots leftby Apr 2025
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