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Antibiotics for Kidney Stones

Phase 4
Recruiting
Led By Ben Chew, MD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Study Summary

This trial will help researchers find the best antibiotic to treat kidney stones caused by bacteria.

Eligible Conditions
  • Kidney Stones

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
any recurrent kidney stones
Secondary outcome measures
Ancillary procedures for stones such as ureteric stenting and nephrostomy tubes
Clostridiuum difficile colitis
ER visit
+6 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Arm A: 2 weeks Abx post PCNLExperimental Treatment1 Intervention
Oral antibiotics: ciprofloxacin, cotrimoxazole-trimethoprim, or macrodantin are administered for 2 weeks at full dose.
Group II: Arm B: 12 weeks/3 months Abx post PCNLActive Control1 Intervention
Oral antibiotics: ciprofloxacin, cotrimoxazole-trimethoprim, or macrodantin are administered for 2 weeks at full dose followed by a suppressive dose for another 10 weeks (total = 12 weeks or 3 months).

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,415 Previous Clinical Trials
2,466,988 Total Patients Enrolled
11 Trials studying Kidney Stones
4,614 Patients Enrolled for Kidney Stones
Ben Chew, MDPrincipal Investigator - University of British Columbia
University of British Columbia
9 Previous Clinical Trials
976 Total Patients Enrolled
3 Trials studying Kidney Stones
725 Patients Enrolled for Kidney Stones

Media Library

ciprofloxacin, cotrimoxazole-trimethoprim, macrodantin Clinical Trial Eligibility Overview. Trial Name: NCT02375295 — Phase 4
Kidney Stones Research Study Groups: Arm B: 12 weeks/3 months Abx post PCNL, Arm A: 2 weeks Abx post PCNL
Kidney Stones Clinical Trial 2023: ciprofloxacin, cotrimoxazole-trimethoprim, macrodantin Highlights & Side Effects. Trial Name: NCT02375295 — Phase 4
ciprofloxacin, cotrimoxazole-trimethoprim, macrodantin 2023 Treatment Timeline for Medical Study. Trial Name: NCT02375295 — Phase 4
Kidney Stones Patient Testimony for trial: Trial Name: NCT02375295 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To what kind of medical issues is ciprofloxacin, cotrimoxazole-trimethoprim and macrodantin typically recommended as treatment?

"Ciprofloxacin, cotrimoxazole-trimethoprim and macrodantin are the most popular medications for treating otitis externa. These drugs have also been successful in managing urinary tract infections caused by entercococcus faecalis, bronchial infection and abdominal maladies."

Answered by AI

Is enrollment in this trial still available?

"Affirmative. The clinicaltrials.gov database indicates that this investigation, which was first advertised on March 1st 2015 is actively recruiting participants. 28 individuals need to be enrolled across 12 different medical centres."

Answered by AI

In which locations has this research been conducted?

"12 different medical sites are enlisting participants for this trial. These include Ohio State University in Athens, Mayo Clinic - Rochester, MN in Rochester, Vanderbilt University in Nashville and additional locations."

Answered by AI

Have any of the drugs ciprofloxacin, cotrimoxazole-trimethoprim, and macrodantin been granted sanction by the FDA?

"Our team at Power assessed the safety of ciprofloxacin, cotrimoxazole-trimethoprim, macrodantin to have a score of 3 due to it already being approved for use in Phase 4 trials."

Answered by AI

Are there any comparable investigations that have employed ciprofloxacin, cotrimoxazole-trimethoprim and macrodantin?

"At this moment, 54 studies are underway that look into ciprofloxacin, cotrimoxazole-trimethoprim, macrodantin; 9 of those have achieved Phase 3. San Diego is the epicentre for most of these trials but they can also be found at 124 distinct sites nationwide."

Answered by AI

What is the cap on the number of individuals involved in this research project?

"This clinical trial seeks 28 participants that fulfill the eligibility requirements. Possible locations where patients might enrol in this research project are Ohio State University (Athens, OH) and Mayo Clinic - Rochester, MN (Rochester, Minnesota)."

Answered by AI

Who else is applying?

What state do they live in?
Texas
Arizona
Other
Maryland
How old are they?
65+
18 - 65
What portion of applicants met pre-screening criteria?
Met criteria
What site did they apply to?
New York University
The Stone Centre, VGH/UBC
Mayo Clinic - Scottsdale/Phoenix, AZ
How many prior treatments have patients received?
3+
0

Why did patients apply to this trial?

I Have kidney stones. I would like to find a answer to my kidney stones.
PatientReceived 1 prior treatment

How responsive is this trial?

Most responsive sites:
  1. Mayo Clinic - Scottsdale/Phoenix, AZ: < 48 hours
Typically responds via
Phone Call
Email
Average response time
  • < 2 Days
Recent research and studies
clinicaltrials.govStudy
Struvite Stones Antibiotic Study
Ben Chew, MD 2015. "Struvite Stones Antibiotic Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02375295.
~3 spots leftby Apr 2025
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