Vericiguat for Heart Failure

Phase-Based Progress Estimates
3
Effectiveness
3
Safety
University of Utah Hospital, Salt Lake City, UT
Heart Failure+2 More
Vericiguat - Drug
Eligibility
18+
All Sexes
What conditions do you have?
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Study Summary

The concept that direct stimulation of soluble guanylate cyclase (sGC) could be a particularly effective approach to increase cyclic guanosine monophosphate (cGMP) in conditions of increased inflammation/oxidative stress, endothelial dysfunction, and reduced nitric oxide (NO) bioavailability. Thus, the aim of the proposed study is to examine the effect of Vericiguat on peripheral vascular function, inflammatory status, and patient health status. The study also aims to identify patients who are particularly likely to benefit from Vericiguat treatment and predict that these patients will be defined by baseline peripheral vascular dysfunction and high inflammatory state.

Eligible Conditions

  • Heart Failure
  • Hearth Failure With Reduced Ejection Fraction (HFrEF)

Treatment Effectiveness

Effectiveness Progress

3 of 3
This is further along than 93% of similar trials

Other trials for Heart Failure

Study Objectives

1 Primary · 5 Secondary · Reporting Duration: Baseline to 12 weeks

Baseline and 12 weeks
Inflammatory Biomarkers serum Interleukin-1β (IL-1β)
Inflammatory Biomarkers serum Interleukin-6 (IL-6)
Visual Analogue Scale (VAS)
Baseline to 12 weeks
Flow-Mediated Dilation (FMD)
Kansas City Cardiomyopathy Questionnaire-12(KCCQ12)
Six-minute walk test (6MWT)

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Other trials for Heart Failure

Side Effects for

Vericiguat
15%Hypotension
7%Anaemia
7%Dizziness
6%Cardiac failure
5%Diarrhoea
5%Nasopharyngitis
5%Dyspnoea
4%Hyperkalaemia
4%Pneumonia
3%Acute kidney injury
2%Syncope
2%Chronic kidney disease
2%Chronic obstructive pulmonary disease
1%Urinary tract infection
1%Sepsis
1%Renal failure
1%Cardiac failure congestive
1%Gastroenteritis
1%Cellulitis
1%Atrial fibrillation
1%Ventricular tachycardia
0%Left ventricular dysfunction
0%Infective exacerbation of chronic obstructive airways disease
0%Abdominal rigidity
0%Infection
0%Wound sepsis
0%Alcohol poisoning
0%Pyelonephritis chronic
0%Ureter abscess
0%Femoral neck fracture
0%Hyperglycaemic hyperosmolar nonketotic syndrome
0%Spinal compression fracture
0%Diabetes with hyperosmolarity
0%Hypochloraemia
0%Adenocarcinoma pancreas
0%Angiocentric lymphoma
0%Hepatic cancer metastatic
0%Hepatic neoplasm
0%Metastases to abdominal cavity
0%Urinary retention
0%Pulmonary hypertension
0%Meningioma
0%Breast cancer
0%Device failure
0%Nephrolithiasis
0%Renal impairment
0%Respiratory failure
0%Tonsillar haemorrhage
0%Neurodermatitis
0%Urticaria
0%Deep vein thrombosis
0%Peripheral vascular disorder
0%Toxic encephalopathy
0%Incarcerated inguinal hernia
0%Angina pectoris
0%Alanine aminotransferase increased
0%Gouty tophus
0%Haemoglobin decreased
0%Bladder neoplasm
0%Colon cancer
0%Acute pulmonary oedema
0%Metastases to lung
0%Rectosigmoid cancer
0%Renal cancer
0%Acute hepatic failure
0%Intracardiac thrombus
0%Cardiac failure acute
0%Biloma
0%Cervical vertebral fracture
0%Multiple injuries
0%Vascular graft occlusion
0%Hyperosmolar state
0%Haematuria
0%Urethral stenosis
0%Peripheral embolism
0%Normocytic anaemia
0%Thrombocytopenia
0%Cardiovascular insufficiency
0%Palpitations
0%Carcinoid syndrome
0%Wound infection
0%Weight decreased
0%Haematoma muscle
0%Rectal cancer
0%Lethargy
0%Delirium
0%Pneumonia aspiration
0%Liver function test abnormal
0%Shock
0%Mitral valve incompetence
0%Corneal dystrophy
0%Jaundice cholestatic
0%Systemic candida
0%Toxicity to various agents
0%Hepatic enzyme abnormal
0%Squamous cell carcinoma of head and neck
0%Cerebral artery stenosis
0%Loss of consciousness
0%Confusional state
0%End stage renal disease
0%Cough
0%Pulmonary infarction
0%Haemorrhage subcutaneous
0%Lower gastrointestinal haemorrhage
0%Subileus
0%Cardiac complication associated with device
0%Acinetobacter bacteraemia
0%Enterococcal infection
0%Erysipelas
0%Intervertebral discitis
0%Ophthalmic herpes zoster
0%Parotid abscess
0%Angiocardiogram
0%Cutaneous T-cell lymphoma
0%Lymphoma
0%Serratia bacteraemia
0%Periodontitis
0%Vomiting
0%Basedow's disease
0%Bradyarrhythmia
0%Hernia
0%Disseminated intravascular coagulation
0%Pulmonary sepsis
0%Skin bacterial infection
0%Atrial flutter
0%Asbestosis
0%Suture related complication
0%Diabetes mellitus inadequate control
0%Bowen's disease
0%Pulmonary mass
0%Vascular occlusion
0%Blood loss anaemia
0%Glucocorticoid deficiency
0%Hydrocele
0%Gastric perforation
0%Melaena
0%Coronary artery disease
0%Ventricular dysfunction
0%Cataract
0%Colitis ischaemic
0%Dental cyst
0%Inguinal hernia, obstructive
0%Gastritis haemorrhagic
0%Generalised oedema
0%Asthenia
0%Medical device pain
0%Cholangitis
0%Vascular stent occlusion
0%Bile duct stone
0%Atypical pneumonia
0%Endocarditis
0%Escherichia urinary tract infection
0%Gas gangrene
0%Gangrene
0%Nosocomial infection
0%Osteomyelitis
0%Pneumonia chlamydial
0%Pneumonia respiratory syncytial viral
0%Pneumonia staphylococcal
0%Pneumonia streptococcal
0%Renal abscess
0%Pyelonephritis acute
0%Tooth abscess
0%Staphylococcal bacteraemia
0%Viral diarrhoea
0%Bone fissure
0%Arteriovenous fistula site complication
0%Chest injury
0%Hip fracture
0%Limb crushing injury
0%Radius fracture
0%Spinal fracture
0%Subdural haematoma
0%Tendon rupture
0%Traumatic ulcer
0%Vasoplegia syndrome
0%Wrist fracture
0%Blood potassium increased
0%Gamma-glutamyltransferase increased
0%Liver function test increased
0%Occult blood positive
0%Diabetes mellitus
0%Dehydration
0%Fluid overload
0%Hypernatraemia
0%Hypocalcaemia
0%Bladder cancer recurrent
0%Colon adenoma
0%Glioblastoma multiforme
0%Metastases to lymph nodes
0%Oropharyngeal squamous cell carcinoma
0%Squamous cell carcinoma
0%Dizziness postural
0%Cognitive disorder
0%Coma
0%Dementia
0%Encephalopathy
0%Facial paralysis
0%Generalised tonic-clonic seizure
0%Neuropathy peripheral
0%Metabolic encephalopathy
0%Subarachnoid haemorrhage
0%Transient ischaemic attack
0%Lead dislodgement
0%Drug use disorder
0%Mental status changes
0%Panic attack
0%Renal artery stenosis
0%Asthma
0%Bronchitis chronic
0%Dyspnoea exertional
0%Hypoxia
0%Pulmonary embolism
0%Pneumothorax
0%Pulmonary haematoma
0%Pulmonary oedema
0%Respiratory disorder
0%Sleep apnoea syndrome
0%Angioedema
0%Henoch-Schonlein purpura
0%Skin ulcer
0%Cardiac rehabilitation therapy
0%Gastrectomy
0%Arterial occlusive disease
0%Peripheral artery thrombosis
0%Hypovolaemic shock
0%Diplopia
0%Atrial tachycardia
0%Ischaemic cardiomyopathy
0%Blindness
0%Vertigo positional
0%Colitis
0%Large intestinal ulcer
0%Device related thrombosis
0%Vascular stent stenosis
0%Liver injury
0%Anal abscess
0%Arteriovenous fistula site infection
0%Gastroenteritis norovirus
0%Perirectal abscess
0%Streptococcal bacteraemia
0%Costal cartilage fracture
0%Overdose
0%Aspartate aminotransferase increased
0%Cortisol decreased
0%Lumbar spinal stenosis
0%Oropharyngeal cancer
0%Polycythaemia vera
0%Suicide attempt
0%Nephrotic syndrome
0%Renal infarct
0%Aortic stenosis
0%Coagulopathy
0%Obstructive pancreatitis
0%Sudden cardiac death
0%Enterobacter bacteraemia
0%Pneumonia viral
0%Catheterisation cardiac
0%Tachyarrhythmia
0%Gastrointestinal arteriovenous malformation
0%Hypothyroidism
0%Eye haemorrhage
0%Constipation
0%Gastric ulcer haemorrhage
0%Ileus
0%Amyloidosis
0%Chronic sinusitis
0%Herpes zoster
0%Implant site infection
0%Implant site cellulitis
0%Osteomyelitis acute
0%Septic shock
0%Adrenal gland cancer metastatic
0%Benign neoplasm of bladder
0%Metastases to central nervous system
0%Pancreatic carcinoma
0%Hepatic encephalopathy
0%Device malfunction
0%Acute respiratory failure
0%Dermatitis bullous
0%Stasis dermatitis
0%Aortic aneurysm repair
0%Central venous catheter removal
0%Bleeding varicose vein
0%Iliac artery occlusion
0%Peripheral venous disease
0%Congestive cardiomyopathy
0%Gastric haemorrhage
0%Oesophageal achalasia
0%Hepatic failure
0%Liver disorder
0%Abscess limb
0%Cholecystitis infective
0%Diarrhoea infectious
0%Febrile infection
0%Infectious pleural effusion
0%Postoperative wound infection
0%Ankle fracture
0%Burns second degree
0%Lower limb fracture
0%Snake bite
0%Urinary retention postoperative
0%Troponin increased
0%Adenocarcinoma of colon
0%Medical device site thrombosis
0%Hepatocellular carcinoma
0%Myelodysplastic syndrome
0%T-cell lymphoma
0%Ischaemic stroke
0%Sensation of foreign body
0%Nephritis
0%Strangulated hernia
0%Urate nephropathy
0%Hyperventilation
0%Skin necrosis
0%Inguinal hernia strangulated
0%Physical deconditioning
0%Fungaemia
0%Gastroenteritis bacterial
0%Infected skin ulcer
0%Fibula fracture
0%Lumbar vertebral fracture
0%Post procedural haemorrhage
0%Chest wall abscess
0%Parainfluenzae virus infection
0%Pseudomembranous colitis
0%Tibia fracture
0%Salmonella bacteraemia
0%Staphylococcal infection
0%Viral upper respiratory tract infection
0%Weight increased
0%Vertebrobasilar insufficiency
0%Depression
0%Renal colic
0%Rhinitis hypertrophic
0%Psoriasis
0%Implantable defibrillator replacement
0%Umbilical hernia
0%Transaminases increased
0%Cardioversion
0%Ureterolithiasis
0%Pleurisy
0%Angina unstable
0%Faecaloma
0%Orthostatic hypotension
0%Gastritis
0%Large intestinal stenosis
0%Enterocolitis viral
0%Postoperative hypotension
0%Anaemia of chronic disease
0%Aortic valve calcification
0%Abdominal pain
0%Impaired healing
0%Amoebic dysentery
0%Pneumonia mycoplasmal
0%Cardiac index abnormal
0%Hyperammonaemia
0%Metastases to bone
0%Brain oedema
0%Hypoxic-ischaemic encephalopathy
0%Lumbar radiculopathy
0%Post stroke epilepsy
0%Status epilepticus
0%Pericarditis
0%Colon neoplasm
0%Pericardial effusion
0%Cardiac pacemaker replacement
0%Complicated appendicitis
0%Large intestinal obstruction
0%Implant site haematoma
0%Appendicitis
0%Bronchitis viral
0%Campylobacter gastroenteritis
0%Localised infection
0%Respiratory tract infection viral
0%Skin infection
0%Staphylococcal sepsis
0%Subcutaneous abscess
0%Typhoid fever
0%Viral infection
0%Fall
0%Humerus fracture
0%Penis injury
0%Sedation complication
0%Gout
0%Musculoskeletal pain
0%Bladder transitional cell carcinoma
0%Carotid artery stenosis
0%Renal mass
0%Atelectasis
0%Interstitial lung disease
0%Obstructive airways disorder
0%Ecchymosis
0%Shock haemorrhagic
0%Splenic infarction
0%Atrioventricular block complete
0%Cardiac failure chronic
0%Bundle branch block left
0%Coronary artery stenosis
0%Retinal artery thrombosis
0%Extrasystoles
0%Heart valve incompetence
0%Phimosis
0%Pyloric stenosis
0%Glaucoma
0%Hypoparathyroidism secondary
0%Haematochezia
0%Eyelid ptosis
0%Large intestinal ulcer perforation
0%Intestinal obstruction
0%Haemorrhoids
0%Gastrointestinal toxicity
0%Abdominal pain upper
0%Pancreatitis
0%General physical health deterioration
0%Epididymitis
0%Gastrooesophageal reflux disease
0%Gingival bleeding
0%Haematemesis
0%Respiratory tract infection
0%Ischaemic enteritis
0%Impaired gastric emptying
0%Large intestine polyp
0%Patella fracture
0%Pancreatolithiasis
0%Diabetic ketoacidosis
0%Pancreatitis chronic
0%Rectal haemorrhage
0%Chest pain
0%Peptic ulcer
0%Implant site erythema
0%Vascular dementia
0%Renal cyst
0%Oedema
0%Vascular stent thrombosis
0%Cardiovascular event prophylaxis
0%Intraocular lens implant
0%Non-cardiac chest pain
0%Cholecystitis acute
0%Cholecystitis
0%Cholangitis acute
0%Hepatitis toxic
0%Hepatocellular injury
0%Hepatic cirrhosis
0%Hepatic congestion
0%Portosplenomesenteric venous thrombosis
0%Bronchitis
0%Clostridium difficile colitis
0%Device related infection
0%Disseminated tuberculosis
0%Diverticulitis
0%Enterococcal bacteraemia
0%Gastroenteritis viral
0%Eye infection bacterial
0%Gastroenteritis salmonella
0%H1N1 influenza
0%Haematoma infection
0%Groin abscess
0%Infected bite
0%Influenza
0%Liver abscess
0%Lower respiratory tract infection
0%Measles
0%Osteomyelitis chronic
0%Otitis externa
0%Pneumonia bacterial
0%Psoas abscess
0%Pyelonephritis
0%Tracheobronchitis
0%Urosepsis
0%Vestibular neuronitis
0%Contusion
0%Burns third degree
0%Concussion
0%Foot fracture
0%Femur fracture
0%Incision site haemorrhage
0%Head injury
0%Limb injury
0%Post procedural haematuria
0%Pelvic fracture
0%Thermal burn
0%Rib fracture
0%Post procedural hypothyroidism
0%Seroma
0%Traumatic fracture
0%Blood creatinine increased
0%Cardiac stress test abnormal
0%Upper limb fracture
0%Ejection fraction decreased
0%Influenza A virus test positive
0%Traumatic liver injury
0%Blood sodium decreased
0%Vascular pseudoaneurysm
0%Heart rate irregular
0%Hepatic enzyme increased
0%International normalised ratio increased
0%Diabetic metabolic decompensation
0%Hypoalbuminaemia
0%Muscular weakness
0%Basal cell carcinoma
0%Benign gastric neoplasm
0%Bladder cancer
0%Bronchial carcinoma
0%Diffuse large B-cell lymphoma
0%Gastric cancer
0%Chronic lymphocytic leukaemia
0%Lymphoproliferative disorder
0%Hepatobiliary cancer
0%Malignant melanoma
0%Plasma cell myeloma
0%Ovarian cancer
0%Plasmacytoma
0%Prostate cancer
0%Renal neoplasm
0%Skin cancer
0%Retroperitoneal cancer
0%Squamous cell carcinoma of the oral cavity
0%Sweat gland tumour
0%Squamous cell carcinoma of lung
0%Tumour ulceration
0%Uterine cancer
0%Dementia Alzheimer's type
0%Cerebral artery embolism
0%Headache
0%Paraesthesia
0%Spinal cord compression
0%Hydrocephalus
0%Hemiparesis
0%Sciatica
0%Tension headache
0%Device battery issue
0%Anxiety
0%Azotaemia
0%Bladder cyst
0%Benign prostatic hyperplasia
0%Haemoptysis
0%Haemothorax
0%Pleural effusion
0%Pleuritic pain
0%Diabetic foot
0%Arrhythmia prophylaxis
0%Cardiac resynchronisation therapy
0%Inguinal hernia repair
0%Aortic dissection
0%Circulatory collapse
0%Extremity necrosis
0%Haematoma
0%Haemorrhagic vasculitis
0%Ischaemia
0%Peripheral arterial occlusive disease
0%Peripheral ischaemia
0%Varicose vein ruptured
0%Arrhythmia
0%Alcoholic pancreatitis
0%Gastrointestinal angiodysplasia
0%Discomfort
0%Ischaemic hepatitis
0%Peritonitis
0%Sinusitis
0%Accidental overdose
0%Thoracic vertebral fracture
0%Cachexia
0%Chondritis
0%Seizure
0%Endometrial hyperplasia
0%Chylothorax
0%Stevens-Johnson syndrome
0%Dry gangrene
0%Tachycardia
0%Left ventricular failure
0%Hyperthyroidism
0%Intestinal infarction
0%Intestinal ischaemia
0%Nausea
0%Oesophageal stenosis
0%Pneumatosis intestinalis
0%Oedema peripheral
0%Cholestasis
0%Enteritis infectious
0%Intestinal sepsis
0%Pneumonia pneumococcal
0%Tuberculous pleurisy
0%West Nile viral infection
0%Arterial bypass occlusion
0%Coronary vascular graft stenosis
0%Facial bones fracture
0%Subdural haemorrhage
0%Anticoagulation drug level above therapeutic
0%Bone density abnormal
0%Hypercalcaemia
0%Hyperglycaemia
0%Adenocarcinoma gastric
0%Enthesopathy
0%Intervertebral disc protrusion
0%Metastatic neoplasm
0%Oesophageal carcinoma
0%Myelopathy
0%Myoclonus
0%Presyncope
0%Alcohol abuse
0%Calculus bladder
0%Nephropathy
0%Epistaxis
0%Pulmonary congestion
0%Thrombophlebitis
0%Cardiac asthma
0%Cardiac ventricular thrombosis
0%Vitreous haemorrhage
0%Aortic valve incompetence
0%Oesophageal varices haemorrhage
0%Small intestinal obstruction
0%Upper gastrointestinal haemorrhage
0%Influenza like illness
0%Chest discomfort
0%Medical device site haematoma
0%Chronic hepatic failure
0%Cellulitis gangrenous
0%Cystitis bacterial
0%Diabetic foot infection
0%Medical device site abscess
0%Peritonitis bacterial
0%Staphylococcal skin infection
0%Upper respiratory tract infection
0%Acetabulum fracture
0%Cardiac valve replacement complication
0%Skin laceration
0%Spinal stenosis
0%Hepatic cancer
0%Inflammatory pseudotumour
0%Prostate cancer metastatic
0%Diabetic neuropathy
0%Anxiety disorder
0%Bladder mass
0%Costovertebral angle tenderness
0%Drug eruption
0%Peripheral artery stenosis
0%Cardiac arrest
0%Cardiopulmonary failure
0%Diabetic retinopathy
0%Sinus bradycardia
0%Sinus node dysfunction
0%Retinal haemorrhage
0%Gastric ulcer
0%Inguinal hernia
0%Large intestinal haemorrhage
0%Large intestinal ulcer haemorrhage
0%Hepatitis acute
0%UGT1A1 gene polymorphism
0%Medical device site swelling
0%Extradural abscess
0%Klebsiella sepsis
0%Pertussis
0%Thrombophlebitis septic
0%Craniocerebral injury
0%Heat illness
0%Pubis fracture
0%Road traffic accident
0%Gouty arthritis
0%Intervertebral disc disorder
0%Musculoskeletal chest pain
0%Tongue neoplasm malignant stage unspecified
0%Device ineffective
0%Device dislocation
0%Bronchial haemorrhage
0%Bronchospasm
0%Implantable defibrillator insertion
0%Implantable defibrillator removal
0%Leg amputation
0%Diabetic vascular disorder
0%Hypertension
0%Hypertensive crisis
0%Intermittent claudication
0%Varicose vein
0%Iron deficiency anaemia
0%Coronary artery occlusion
0%Bradycardia
0%Atrioventricular block second degree
0%Gastritis erosive
0%Acute myocardial infarction
0%Erosive oesophagitis
0%Blood urea increased
0%Dysarthria
0%Ventricular arrhythmia
0%Lymphorrhoea
0%Vertigo
0%Atrioventricular block
0%Gastrointestinal haemorrhage
0%Macular cyst
0%Pancreatitis acute
0%Cauda equina syndrome
0%Autoimmune haemolytic anaemia
0%Bicytopenia
0%Bone marrow failure
0%Normochromic normocytic anaemia
0%Hypocoagulable state
0%Acute coronary syndrome
0%Hypoglycaemia
0%Hypokalaemia
0%Hypomagnesaemia
0%Hyponatraemia
0%Hypophosphataemia
0%Hypovolaemia
0%Ketoacidosis
0%Marasmus
0%Metabolic acidosis
0%Metabolic alkalosis
0%Mineral metabolism disorder
0%Type 2 diabetes mellitus
0%Pancytopenia
0%Arteriosclerosis coronary artery
0%Atrial thrombosis
0%Cardiac perforation
0%Aortic valve stenosis
0%Cardiorenal syndrome
0%Cardio-respiratory arrest
0%Cardiogenic shock
0%Arthralgia
0%Arthritis
0%Back pain
0%Cervical spinal stenosis
0%Ventricular extrasystoles
0%Myocardial ischaemia
0%Myocardial infarction
0%Barrett's oesophagus
0%Cardiovascular disorder
0%Anorectal ulcer
0%Supraventricular tachycardia
0%Ventricular fibrillation
0%Abdominal distension
0%Diverticulum
0%Intra-abdominal haematoma
0%Ascites
0%Osteoarthritis
0%Osteonecrosis
0%Pain in extremity
0%Pathological fracture
0%Polyarthritis
0%Rhabdomyolysis
0%Rheumatoid arthritis
0%Sjogren's syndrome
0%Spinal pain
0%Spondylitis
0%Tendonitis
0%Abdominal pain lower
0%Dental caries
0%Duodenal ulcer
0%Diverticulum intestinal
0%Lung adenocarcinoma
0%Lung cancer metastatic
0%Lung neoplasm malignant
0%Haemorrhoidal haemorrhage
0%Incarcerated umbilical hernia
0%Pancreatic carcinoma metastatic
0%Implant site haemorrhage
0%Multiple organ dysfunction syndrome
0%Pyrexia
0%Cholecystitis chronic
0%Cholelithiasis
0%Uterine leiomyoma
0%Waldenstrom's macroglobulinaemia
0%Altered state of consciousness
0%Autonomic neuropathy
0%Axonal neuropathy
0%Brain hypoxia
0%Brain injury
0%Bacteraemia
0%Bacterial sepsis
0%Lower respiratory tract infection viral
0%Lung infection
0%Myocarditis infectious
0%Necrotising fasciitis
0%Cystitis
0%Blood bilirubin increased
0%Cerebral haemorrhage
0%Cerebral infarction
0%Cerebral ischaemia
0%Cerebrovascular accident
0%Cerebrovascular disorder
0%Nephroprotective therapy
0%Therapeutic procedure
0%Toe operation
0%Aortic aneurysm
0%Peripheral artery occlusion
This histogram enumerates side effects from a completed 2019 Phase 3 trial (NCT02861534) in the Vericiguat ARM group. Side effects include: Hypotension with 15%, Anaemia with 7%, Dizziness with 7%, Cardiac failure with 6%, Diarrhoea with 5%.

Trial Design

2 Treatment Groups

Vericiguat
1 of 2
Placebo
1 of 2
Experimental Treatment
Non-Treatment Group

24 Total Participants · 2 Treatment Groups

Primary Treatment: Vericiguat · Has Placebo Group · Phase 4

Vericiguat
Drug
Experimental Group · 1 Intervention: Vericiguat · Intervention Types: Drug
Placebo
Drug
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Vericiguat
2016
Completed Phase 3
~5050

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline to 12 weeks
Closest Location: University of Utah Hospital · Salt Lake City, UT
Photo of Salt Lake City  1Photo of Salt Lake City  2Photo of Salt Lake City  3
2007First Recorded Clinical Trial
8 TrialsResearching Heart Failure
69 CompletedClinical Trials

Eligibility Criteria

Age 18+ · All Participants · 5 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You have a systemic blood pressure of 90/60 mmHg or higher.
This guideline is for patients with heart failure who are receiving guideline-directed therapy.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.