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Vaccine

Influenza Vaccine for Miscarriages (DE-FluVac Trial)

Phase 4
Waitlist Available
Led By David H Barad, MD, MS
Research Sponsored by Center for Human Reproduction
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 14 to 21 days (at time of egg retrieval)
Awards & highlights

DE-FluVac Trial Summary

This study is evaluating whether influenza vaccination can improve pregnancy rates in women undergoing in vitro fertilization.

Eligible Conditions
  • Miscarriages
  • Infertility

DE-FluVac Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~14 to 21 days (at time of egg retrieval)
This trial's timeline: 3 weeks for screening, Varies for treatment, and 14 to 21 days (at time of egg retrieval) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Clinical Pregnancy
Secondary outcome measures
Evidence of immune activation
Implantation Rate

Side effects data

From 2015 Phase 4 trial • 985 Patients • NCT02290691
64%
Tenderness
48%
Pain
35%
Redness
29%
Swelling
24%
Itching
20%
Muscle Ache
15%
Headache
12%
Fatigue
10%
Bruising
5%
Chills
4%
Nausea
1%
Vomiting
1%
Fever
100%
80%
60%
40%
20%
0%
Study treatment Arm
Needle- Free
Needle and Syringe

DE-FluVac Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Influenza VaccineExperimental Treatment1 Intervention
O.5 mL single dose influenza vaccine suspension administered intramuscularly
Group II: Saline InjectionPlacebo Group1 Intervention
O.5 ml of sterile Saline administered intramuscularly
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Influenza B virus B/Brisbane/60/2008 antigen (propiolactone inactivated)
FDA approved

Find a Location

Who is running the clinical trial?

Center for Human ReproductionLead Sponsor
13 Previous Clinical Trials
1,041 Total Patients Enrolled
Foundation for Human ReproductionUNKNOWN
1 Previous Clinical Trials
238 Total Patients Enrolled
Norbert Gleicher, MDStudy DirectorMedical Director
8 Previous Clinical Trials
699 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Effect of Influenza Vaccination on Donor Egg Recipient Outcomes
2017. "Effect of Influenza Vaccination on Donor Egg Recipient Outcomes". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02946177.
All > Influenza
~15 spots leftby Apr 2025
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