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Monoclonal Antibodies

Patients with XLH for Hypophosphatemia

Phase 4
Waitlist Available
Led By Karl L Insogna, M.D.
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2.5 months
Awards & highlights

Study Summary

This trial will test if a new treatment for XLH, Crysvita, can help improve symptoms of fatigue and weakness.

Eligible Conditions
  • Hypophosphatemia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2.5 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2.5 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Skeletal Muscle Adenosine Triphosphate (ATP) Synthesis Rate
Secondary outcome measures
Intracellular Phosphate Concentration in Umol/g Muscle
Serum Phosphate
Other outcome measures
Sit to Stand
Six-minute Walk Test
Timed up and go Test

Side effects data

From 2022 Phase 4 trial • 10 Patients • NCT04146935
10%
Partial ureteropelvic junction obstruction by staghorn calculus
100%
80%
60%
40%
20%
0%
Study treatment Arm
Patients With XLH

Trial Design

1Treatment groups
Experimental Treatment
Group I: Patients with XLHExperimental Treatment1 Intervention
Patients will receive Burosumab monthly at visits 1,2 and 3 subcutaneously at a dose of 1.0 mg/kg. Dose may be adjusted as needed.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Burosumab Injection [Crysvita]
2019
Completed Phase 4
~10

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,854 Previous Clinical Trials
2,740,551 Total Patients Enrolled
3 Trials studying Hypophosphatemia
84 Patients Enrolled for Hypophosphatemia
Karl L Insogna, M.D.Principal InvestigatorYale University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Examining the Effect of Burosumab on Muscle Function
2019. "Examining the Effect of Burosumab on Muscle Function". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04146935.
~2 spots leftby May 2025
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