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Tetracycline Antibiotic

Minocycline for High Blood Pressure

Phase 4
Recruiting
Led By Carl Pepine, MD
Research Sponsored by University of Florida
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 52 weeks
Awards & highlights

Study Summary

This trial is testing whether minocycline, a drug that is already FDA approved, can help treat neurogenic hypertension, which is a type of hypertension that is caused by overactivity of the sympathetic nervous system.

Who is the study for?
This trial is for adults aged 18-85 with high blood pressure that's not controlled despite taking three different types of blood pressure meds, including a diuretic. They must be on a stable medication regimen and willing to consent to study procedures. It excludes those with poor kidney function, women who can get pregnant, people allergic to Minocycline or tetracyclines, substance abusers, recent hospitalization for severe hypertension crisis or frequent drops in blood pressure upon standing.Check my eligibility
What is being tested?
The study tests whether increasing doses of Minocycline can lower blood pressure in patients whose hypertension doesn't respond well to drugs. It explores the idea that Minocycline might calm overactive nerves that contribute to high blood pressure by crossing into the brain and reducing inflammation there.See study design
What are the potential side effects?
Minocycline is generally safe and FDA-approved but may cause side effects like dizziness, fatigue, changes in color of skin/gums/teeth/nails/scars/stretch marks/saliva/sweat/urine/bowel movements (may become permanent), sores or swelling in your rectum or genital area.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~52 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 52 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Reduction in mean daytime ABPM SBP and/or down titration of antihypertensive therapy
Secondary outcome measures
Change in 24 hr SBP by ABPM
Changes in office SBP over time

Trial Design

1Treatment groups
Experimental Treatment
Group I: Minocycline Dose EscalationExperimental Treatment1 Intervention
Subjects will receive minocycline 50mg if no mean daytime ABPM SBP decline =/> 5mm Hg; subjects will receive minocycline 100mg, if no mean daytime ABPM SBP decline =/> 5mm Hg BP subjects will receive minocycline 200 mg.

Find a Location

Who is running the clinical trial?

National Heart, Lung, and Blood Institute (NHLBI)NIH
3,836 Previous Clinical Trials
47,850,863 Total Patients Enrolled
University of FloridaLead Sponsor
1,340 Previous Clinical Trials
715,670 Total Patients Enrolled
Carl Pepine, MDPrincipal InvestigatorUniversity of Florida
6 Previous Clinical Trials
190 Total Patients Enrolled

Media Library

Minocycline (Tetracycline Antibiotic) Clinical Trial Eligibility Overview. Trial Name: NCT02133872 — Phase 4
High Blood Pressure Research Study Groups: Minocycline Dose Escalation
High Blood Pressure Clinical Trial 2023: Minocycline Highlights & Side Effects. Trial Name: NCT02133872 — Phase 4
Minocycline (Tetracycline Antibiotic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02133872 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To what maladies is this intervention typically administered?

"Typically, this medication is used to tackle Rocky Mountain Spotted Fever. It has a range of other therapeutic applications, including but not limited to: Q fever, dental root planing and respiratory tract infections."

Answered by AI

Is the age restriction for participants in this study greater than or equal to 35 years?

"This trial is specifically seeking individuals between 18 and 85 years of age. Alternatively, those under the legal age or over 65 can participate in 58 and 675 trials respectively."

Answered by AI

What are the potential harms of this intervention?

"Patient safety is prioritized in this phase 4 trial, thus the treatment scores a 3 on our team's rating system. This indicates that it has already been authorized for use by regulatory bodies."

Answered by AI

Could you please explain the findings of any previous investigations into this treatment?

"At present, there exists 20 trials exploring this particular treatment. Out of those active clinical investigations, 6 are in their concluding phase (3). These studies span 37 locations with the majority centered around Guangzhou, Guangdong."

Answered by AI

What is the aggregate patient count of this clinical experiment?

"Affirmative. According to information on clinicaltrials.gov, this medical study is currently inviting patients to participate; the trial was first advertised on October 1st 2014 and recently modified on May 23rd 2022. 35 individuals must be recruited from a single site for the research to go ahead as planned."

Answered by AI

Is the clinical trial open to all individuals who meet certain criteria?

"Patients with hypertension and aged 18 to 85 are being considered for this clinical trial. A total of 35 participants will be accepted into the program."

Answered by AI

Are there any openings for individuals to take part in this experiment?

"Indeed, the information hosted on clinicaltrials.gov shows that this trial is currently enrolling patients. It was first posted October 1st 2014 and last edited May 23rd 2022, seeking to recruit 35 individuals from one site."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Study 1: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients
2014. "Study 1: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02133872.
~3 spots leftby Apr 2025
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