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Mineralocorticoid Receptor Antagonist

Eplerenone 50mg for High Blood Pressure (ENOVA Trial)

Phase 4
Waitlist Available
Led By J Brian Byrd, MD, MS
Research Sponsored by University of Michigan
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Systolic blood pressure (SBP) ≥ 140 millimeters of Mercury (mmHg) or diastolic blood pressure (DBP) ≥ 90 mmHg on 2 occasions
Treatment with 1-2 antihypertensive medications (stable dose for 6 weeks)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 12 (after second study treatment)
Awards & highlights

ENOVA Trial Summary

This trial will enroll participants with mild stage 1 hypertension to see if a certain kind of protein in their urine can predict if they will respond to a specific kind of blood pressure medication.

ENOVA Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

ENOVA Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 12 (after second study treatment)
This trial's timeline: 3 weeks for screening, Varies for treatment, and week 12 (after second study treatment) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Mineralocorticoid Receptor
RNA, Messenger

Side effects data

From 2017 Phase 2 trial • 17 Patients • NCT01822561
7%
Shortness of breath
7%
Palpitations
100%
80%
60%
40%
20%
0%
Study treatment Arm
Eplerenone Group

ENOVA Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: EplerenoneExperimental Treatment1 Intervention
Participants will be randomized to receive 4 weeks of Eplerenone and then 4 weeks of Placebo.
Group II: PlaceboPlacebo Group1 Intervention
Participants will be randomized to receive 4 weeks of placebo and then 4 weeks of Eplerenone.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Eplerenone 50mg
2013
Completed Phase 2
~20

Find a Location

Who is running the clinical trial?

University of MichiganLead Sponsor
1,788 Previous Clinical Trials
6,365,539 Total Patients Enrolled
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,827 Previous Clinical Trials
47,300,827 Total Patients Enrolled
J Brian Byrd, MD, MSPrincipal InvestigatorUniversity of Michigan
1 Previous Clinical Trials
21 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the administration of Eplerenone 50mg sanctioned by the FDA?

"The safety of taking Eplerenone 50mg was rated a 3 as it is in Phase 4, signifying that the drug has already been approved."

Answered by AI

To whom is this experimental research open?

"This clinical trial seeks 30 individuals aged 21 to 65 who have hypertension. Applicants must demonstrate a Systolic Blood Pressure (SBP) of 140 mmHg or higher, and Diastolic Blood Pressure (DBP) of 90 mmHg or higher on two occasions, as well as having been taking 1-2 antihypertensive medications for at least 6 weeks."

Answered by AI

Could you provide an overview of the illnesses typically treated with Eplerenone 50mg?

"Eplerenone 50mg is a viable treatment option for individuals with LVF lower than 40%, congestive heart failure, hypertensive disease, and hypesthesia."

Answered by AI

Are geriatric patients eligible for participation in this experiment?

"This study's inclusion criteria necessitates potential trial goers between the ages of 21 and 65. Apart from this research, there are 56 trials aimed at younger patients and 674 studies targeted towards seniors."

Answered by AI

Are there any vacant positions still available for participants in this clinical investigation?

"This particular clinical trial is no longer recruiting. It was initially posted on October 1st 2022 and most recently edited on September 16th of the same year. However, there are 746 trials actively looking for participants with hypertension as well as 13 different studies searching for those taking eplerenone 50mg medication."

Answered by AI

How many test subjects have been accepted into this clinical research?

"Unfortunately, this trial is no longer accepting participants. It was initially listed on October 1st 2022 and most recently updated September 16th 2022. To help with your search for clinical trials, there are currently 746 studies actively looking for people with hypertension and 13 more seeking patients to take Eplerenone 50mg."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Effect of Eplerenone on Novel Biomarkers of Mineralocorticoid Receptor Activation (ENOVA)
J Brian Byrd, MD, MS 2023. "Effect of Eplerenone on Novel Biomarkers of Mineralocorticoid Receptor Activation (ENOVA)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04746495.
~0 spots leftby Apr 2025
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