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Anti-hypertensive

Anti-hypertensive therapy for High Blood Pressure (CHAP Trial)

Q: Have prior investigations been conducted regarding Anti-hypertensive methods of treatment?

Anti-hypertensive drugs were first researched in 2007 at the Clinical Research Center of Western General Hospital. To date, 82 such studies have concluded and 17 are still ongoing - many being conducted out of Marshfield, <a href="https://www.withpower.com/clinical-trials/wisconsin">Wisconsin</a>.

Q: Are there numerous establishments administering this research in Canada?

This medical trial is being conducted in Marshfield Clinic situated in Marshfield, <a href="https://www.withpower.com/clinical-trials/wisconsin">Wisconsin</a>; <a href="https://www.withpower.com/clinical-trials/ohio">Ohio</a> State University located at Columbus, Ohio and the University of <a href="https://www.withpower.com/clinical-trials/utah">Utah</a> based out of Salt Lake City Utah. Moreover, there are 49 other sites taking part too.

Q: Are there any potential risks associated with Anti-hypertensive treatment?

Due to its Phase 4 trial status, Anti-hypertensive therapy is granted a score of 3 on our team's scale for safety. This signifies that this treatment has been approved and implemented with prior successful clinical trials.

Q: Are there any available positions remaining in this clinical investigation?

Data from clinicaltrials.gov shows that this trial is not taking on additional patients at present, despite having originally been posted in June 2015 and last updated in September 2022. Despite the lack of recruitment for the current study, there are 763 medical trials actively seeking participants across a wide range of conditions.

Q: Is this trial a precedent for similar studies?

Since the initial study in 2007, sponsored by Encysive Pharmaceuticals and consisting of 27 participants, there has been a steady increase in research surrounding anti-hypertensive therapy. Following Phase 1 approval, 17 clinical trials are now live across 66 cities scattered throughout 6 nations.

Q: To what health issues is anti-hypertensive therapy typically prescribed?

Anti-hypertensive therapy is typically deployed to manage vasospastic angina, with additional applications for pheochromocytomas, altitude sickness, and preterm labour.

Q: What is the scope of recruitment for this scientific exploration?

This trial is not currently open for enrollment. It was initially posted in June of 2015 and the most recent update was published at the end of September 2022. However, if you are seeking other clinical trials related to <a href="https://www.withpower.com/clinical-trials/hypertension">hypertension</a>, there are presently 746 studies actively recruiting participants as well as 17 more specifically focused on Anti-hypertensive therapy that accept new patients.

Phase 4

Waitlist Available

Led By Jeffery Szychowski, PhD

Research Sponsored by University of Alabama at Birmingham

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 3 months postpartum

Awards & highlights

CHAP Trial Summary

This trial will compare two blood pressure treatment strategies during pregnancy.

CHAP Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 3 months postpartum

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 3 months postpartum

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 3 months postpartum for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Composite Adverse Perinatal Outcome

Small for Gestational Age (Safety)

Secondary outcome measures

Adherence to Treatment After Delivery

Composite of Maternal Death or Severe Cardiovascular Morbidity

Composite of Severe Neonatal Morbidities

+2 more

Other outcome measures

5-min Apgar Score

Blood Transfusion

Bradycardia

+23 more

Side effects data

From 2022 Phase 4 trial • 2408 Patients • NCT02299414

Foetal Death

Preeclampsia

Stillbirth

General Event

100%

80%

60%

40%

20%

Study treatment Arm

Anti-hypertensive Therapy to Goal <140/90 mmHg

No Anti-hypertensive Unless BP is Severe (≥160/105 mmHg

CHAP Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Anti-hypertensive therapy to goal <140/90 mmHgExperimental Treatment1 Intervention

Labetalol or Nifedipine ER will be used as first-line to achieve goal; if necessary Nifedipine ER or Labetalol will be second-line antihypertensive. Rarely, other antihypertensive medications may also be used

Group II: No anti-hypertensive unless BP is severe (≥160/105 mmHgActive Control1 Intervention

Antihypertensive therapy given only if BP becomes severe (defined as BP ≥160/105). The lowest dose of anti-hypertensive needed to keep blood pressure below this threshold will be given (1st-line - Labetalol or Nifedipine ER and 2nd-line - Labetalol or Nifedipine ER). Rarely other medications may be used

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Anti-hypertensive therapy

2015

Completed Phase 4

~2410

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of Tennessee Health Science CenterOTHER

48 Previous Clinical Trials

22,696 Total Patients Enrolled

University of Alabama at BirminghamLead Sponsor

1,588 Previous Clinical Trials

2,277,904 Total Patients Enrolled

Columbia UniversityOTHER

1,432 Previous Clinical Trials

2,458,565 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Have prior investigations been conducted regarding Anti-hypertensive methods of treatment?

"Anti-hypertensive drugs were first researched in 2007 at the Clinical Research Center of Western General Hospital. To date, 82 such studies have concluded and 17 are still ongoing - many being conducted out of Marshfield, Wisconsin."

Answered by AI

Are there numerous establishments administering this research in Canada?

"This medical trial is being conducted in Marshfield Clinic situated in Marshfield, Wisconsin; Ohio State University located at Columbus, Ohio and the University of Utah based out of Salt Lake City Utah. Moreover, there are 49 other sites taking part too."

Answered by AI

Are there any potential risks associated with Anti-hypertensive treatment?

"Due to its Phase 4 trial status, Anti-hypertensive therapy is granted a score of 3 on our team's scale for safety. This signifies that this treatment has been approved and implemented with prior successful clinical trials."

Answered by AI

Are there any available positions remaining in this clinical investigation?

"Data from clinicaltrials.gov shows that this trial is not taking on additional patients at present, despite having originally been posted in June 2015 and last updated in September 2022. Despite the lack of recruitment for the current study, there are 763 medical trials actively seeking participants across a wide range of conditions."

Answered by AI

Is this trial a precedent for similar studies?

"Since the initial study in 2007, sponsored by Encysive Pharmaceuticals and consisting of 27 participants, there has been a steady increase in research surrounding anti-hypertensive therapy. Following Phase 1 approval, 17 clinical trials are now live across 66 cities scattered throughout 6 nations."

Answered by AI

To what health issues is anti-hypertensive therapy typically prescribed?

"Anti-hypertensive therapy is typically deployed to manage vasospastic angina, with additional applications for pheochromocytomas, altitude sickness, and preterm labour."

Answered by AI

What is the scope of recruitment for this scientific exploration?

"This trial is not currently open for enrollment. It was initially posted in June of 2015 and the most recent update was published at the end of September 2022. However, if you are seeking other clinical trials related to hypertension, there are presently 746 studies actively recruiting participants as well as 17 more specifically focused on Anti-hypertensive therapy that accept new patients."

Answered by AI