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Calcium Channel Blocker and Angiotensin II Receptor Blocker Combination

Azor-Treatment A for High Blood Pressure (AMORE Trial)

Phase 4
Waitlist Available
Led By Bobby V Khan, MD, PhD
Research Sponsored by InVasc Therapeutics, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 25 weeks
Awards & highlights

AMORE Trial Summary

The purpose of the study is to compare the effects of Azor (a combination of amlodipine and olmesartan) with Hyzaar ( a combination of losartan and hydrochlorothiazide) on the thin lining on the inside of blood vessels. These cells help keep blood vessels healthy and blood pressure normal.

AMORE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~25 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 25 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Central Aortic Pressure (CAP)
Secondary outcome measures
Blood pressure control

AMORE Trial Design

2Treatment groups
Active Control
Group I: Azor-Treatment AActive Control1 Intervention
Weeks 1-2: Azor® 5/20 Weeks 3-14: Azor® 10/40 Weeks 15-18: Azor® 10/40+HCTZ 25 Weeks 19-20: Azor® 10/40+HCTZ 25 + spironolactone 25 once daily
Group II: Hyzaar-Treatment Arm BActive Control1 Intervention
Weeks 1-2: Hyzaar® 50/12.5 Weeks 3-14: Hyzaar® 100/25 Weeks 15-18: Azor® 10/40+HCTZ 25 Weeks 19-20: Azor® 10/40+HCTZ 25 + spironolactone 25 once daily

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Who is running the clinical trial?

InVasc Therapeutics, Inc.Lead Sponsor
3 Previous Clinical Trials
151 Total Patients Enrolled
Bobby V Khan, MD, PhDPrincipal InvestigatorDirector, Atlanta Clinical Research Centers
Keith C Ferdinand, MDStudy DirectorAtlanta Clinical Research Centers

Frequently Asked Questions

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