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Diuretic

Hydrochlorothiazide 25 mg for High Blood Pressure

Phase 4
Waitlist Available
Led By Khalid Bashir, MD
Research Sponsored by Creighton University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 weeks
Awards & highlights

Study Summary

This will be a randomized, double-blinded, three-period crossover study of platelet activation and aggregation in 30 non-smoking healthy volunteers comparing chlorthalidone (CTD), hydrochlorothiazide (HCTZ), and aspirin (ASA; active control). The study hypothesis is that CTD has different effects on platelet activation and aggregation than HCTZ.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in mean fluorescence intensity of PAC-1
Secondary outcome measures
Change in CD62P expression
Change in platelet aggregation

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Hydrochlorothiazide 25 mgExperimental Treatment1 Intervention
Hydrochlorothiazide 25 mg by mouth once daily for 2 weeks
Group II: Chlorthalidone 12.5 mgExperimental Treatment1 Intervention
Chlorthalidone 12.5 mg by mouth once daily for 2 weeks
Group III: Aspirin 81 mgActive Control1 Intervention
Aspirin 81 mg by mouth once daily for 2 weeks
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Hydrochlorothiazide
FDA approved

Find a Location

Who is running the clinical trial?

Creighton UniversityLead Sponsor
125 Previous Clinical Trials
25,666 Total Patients Enrolled
Dialysis Clinic, Inc.Industry Sponsor
23 Previous Clinical Trials
11,888 Total Patients Enrolled
Khalid Bashir, MDPrincipal InvestigatorCreighton University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Chlorthalidone and HCTZ Impacts on Platelet Activation
2014. "Chlorthalidone and HCTZ Impacts on Platelet Activation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02100462.
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~3 spots leftby Apr 2025
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