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Standard Postpartum Care for Prophylaxis of Preeclampsia

Phase 4

Waitlist Available

Led By Richard Lee, MD

Research Sponsored by University of Southern California

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 48, 72 and 96 hours postpartum

Awards & highlights

Study Summary

This trial will determine whether postpartum standard care withholding NSAID use is associated with a clinically significant reduction in postpartum hypertension in women with pregnancy induced hypertension.

Eligible Conditions

Prophylaxis of Preeclampsia
Hypertension
Pre-eclampsia
Hypertension in Pregnancy

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 48, 72 and 96 hours postpartum

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~48, 72 and 96 hours postpartum

This trial's timeline: 3 weeks for screening, Varies for treatment, and 48, 72 and 96 hours postpartum for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Secondary outcome measures

Initiation of anti-hypertensive medication

Length of hospital stay

Number of participants who die

+6 more

Trial Design

2Treatment groups

Active Control

Group I: Standard Postpartum CareActive Control1 Intervention

Subjects will receive NSAIDs (e.g. ibuprofen, ketorolac) for routine postpartum pain management.

Group II: Standard Postpartum Care without NSAIDsActive Control1 Intervention

Subjects will receive standard postpartum care without NSAID administration for pain management. Acetaminophen or narcotics will be substituted for ibuprofen as indicated by provider.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of Southern CaliforniaLead Sponsor

905 Previous Clinical Trials

1,596,290 Total Patients Enrolled

Richard Lee, MDPrincipal InvestigatorUniversity of Southern California

5 Previous Clinical Trials

1,264 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does the FDA sanction Standard Postpartum Care without NSAIDs?

"From the perspective of our team at Power, the safety rating for Standard Postpartum Care without NSAIDs was assigned a 3 due to its Phase 4 status: namely that it is approved by governing bodies."

Answered by AI

What is the typical purpose of Standard Postpartum Care that does not involve Nonsteroidal Anti-inflammatory Drugs (NSAIDs)?

"Standard Postpartum Care, sans Non-steroidal Anti Inflammatory Drugs (NSAIDs), is the norm for treating catarrh. Other ailments that this intervention may assist with include muscle spasms, fever, and pain relief."

Answered by AI

Are any participation slots still available for this trial?

"Correct. Clinicaltrials.gov's records show that this research is actively recruiting, having been initially posted on December 11th 2018 and last edited on November 4th 2020. 200 test subjects are needed from one center."

Answered by AI

Have any other investigations been conducted to evaluate the efficacy of Standard Postpartum Care excluding non-steroidal anti-inflammatory drugs?

"Presently, 43 clinical studies are underway dedicated to exploring Standard Postpartum Care without NSAIDs. Of those ongoing trials, 10 have entered Phase 3. The bulk of the experiments for this treatment take place in Pittsburgh but there are 91 other locations under investigation as well."

Answered by AI

What is the magnitude of individuals participating in this research?

"That is correct. According to the details available on clinicaltrials.gov, this trial began recruiting participants in December 2018 and was last edited in November 2020. 200 patients are needed across a single site for successful completion of this study."

Answered by AI

Recent research and studies

Annals of Internal MedicineJournal

Do Nonsteroidal Anti-inflammatory Drugs Affect Blood Pressure? A Meta-analysis

Johnson, Anthony G.. 1994. “Do Nonsteroidal Anti-inflammatory Drugs Affect Blood Pressure? A Meta-analysis”. Annals of Internal Medicine. American College of Physicians. doi:10.7326/0003-4819-121-4-199408150-00011.

American Journal of Obstetrics and GynecologyJournal

Antagonism of Antihypertensive Drug Therapy in Pregnancy by Indomethacin?

Schoenfeld, A., S. Freedman, M. Hod, and Y. Ovadia. 1989. “Antagonism of Antihypertensive Drug Therapy in Pregnancy by Indomethacin?”. American Journal of Obstetrics and Gynecology. Elsevier BV. doi:10.1016/0002-9378(89)90666-2.

American Journal of Obstetrics and GynecologyJournal

Postpartum Hypertension and Nonsteroidal Analgesia

Makris, Angela, Charlene Thornton, and Annemarie Hennessy. 2004. “Postpartum Hypertension and Nonsteroidal Analgesia”. American Journal of Obstetrics and Gynecology. Elsevier BV. doi:10.1016/j.ajog.2003.08.030.

Cardiology in ReviewJournal