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Determine the presence of the human sequence of Ang-(1-12) in plasma on no medications for High Blood Pressure

Phase 4
Recruiting
Led By Henry Punzi, MD
Research Sponsored by Trinity Hypertension & Metabolic Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up four weeks
Awards & highlights

Study Summary

This trial tested Lisinopril 40mg on 10 people with hypertension to see if it lowered their blood pressure.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and at baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Presence of human sequence of Ang-(1-12) in plasma ten untreated essential hypertensive subjects at baseline
Secondary outcome measures
Presence of human sequence of Ang-(1-12) in plasma of ten subjects on four weeks of treatment on Lisinopril 40 mg every day

Trial Design

2Treatment groups
Active Control
Group I: Determine the presence of the human sequence of Ang-(1-12) in plasma on no medicationsActive Control1 Intervention
Determine the presence of the human sequence of Ang-(1-2) in the plasma of ten normal male and female hypertensive patients at baseline on no medications.
Group II: Determine the presence of human sequence of Ang-(1-12) on Lisinopril 40 mg every dayActive Control1 Intervention
Determine the presence of the human sequence of Ang-(1-12) in the plasma of 10 normal male and female hypertensive patients at baseline and after four weeks on Lisinopril 40 mg every day

Find a Location

Who is running the clinical trial?

Trinity Hypertension & Metabolic Research InstituteLead Sponsor
3 Previous Clinical Trials
145 Total Patients Enrolled
Wake Forest University Health SciencesOTHER
1,238 Previous Clinical Trials
1,004,093 Total Patients Enrolled
Henry Punzi, MDPrincipal InvestigatorTrinity Hypertension & Metabolic Researach Institute

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research endeavor include individuals aged eighty and above?

"This research is searching for individuals aged between 40 and 75 to participate in their clinical trial."

Answered by AI

Have any openings become available in this research initiative?

"As per clinicaltrials.gov, this medical research is recruiting individuals for participation. This trial was initially shared on November 15th 2022 and its details were recently modified on December 6th 2022."

Answered by AI

What repercussions can be anticipated when human sequence of Ang-(1-12) is detected in the plasma and no medications are prescribed?

"There is ample proof of Determine the presence of the human sequence of Ang-(1-12) in plasma's safety, thus a score of 3 has been given. This treatment is already approved by authorities and this trial marks its fourth phase."

Answered by AI

How many volunteers have signed up for this medical study thus far?

"Affirmative. The information posted on clinicaltrials.gov verifies that this medical research, initially published on November 15th 2022, is actively enrolling participants. To meet their recruitment quota, the study requires 10 individuals from a single site."

Answered by AI

May I partake in this medical investigation?

"This clinical trial is currently accepting applications from 10 adults aged 40 to 75 with hypertension. Criteria for potential candidates include the capacity to read, understand and sign a consent form; be willing to comply with study visits/procedures; no recent use of anti-hypertensive medications (6 months prior); diastolic blood pressure greater than or equal to 90mmHg but less than 109mHg as well as systolic between 140mmHg and 179 mm HG at visit 1; negative pregnancy test (for female applicants of childbearing age) and adherence to one form of birth control throughout the duration of the"

Answered by AI

Who else is applying?

What state do they live in?
Texas
What site did they apply to?
Punzi Medical Center
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

I have high blood pressure that seems to be resistant to most medications. I scared I will get a stroke if I don’t get it together.
PatientReceived no prior treatments

How responsive is this trial?

Typically responds via
Phone Call
Most responsive sites:
  1. Punzi Medical Center: < 24 hours
Average response time
  • < 1 Day
Recent research and studies
clinicaltrials.govStudy
Chymase Angiotensin-(1-12) Axis In Hypertensive Disease
Henry Anthony Punzi 2022. "Chymase Angiotensin-(1-12) Axis In Hypertensive Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05644769.
~4 spots leftby Apr 2025
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