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Endothelial cell collection for High Blood Pressure

Phase 4
Waitlist Available
Led By Wanpen Vongpatanasin, MD
Research Sponsored by Wanpen Vongpatanasin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 day
Awards & highlights

Study Summary

This trial is testing how aldosterone affects nerves that control blood flow and sugar levels - information that could help with choosing blood pressure medication.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 day
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 day for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Increase in muscle sympathetic nerve activity during hyperinsulinemic euglycemic clamp
Secondary outcome measures
Change in endothelial cell protein expression after hyperinsulinemic euglycemic clamp
Change in endothelial cell protein expression after saline infusion
Change in microvascular blood flow during hyperinsulinemic euglycemic clamp.
+2 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Initial Saline InfusionExperimental Treatment5 Interventions
We will perform the following procedures: DEFINITY® infusion Human Recombinant Regular Insulin infusion Dextrose infusion Flow mediated vasodilation Endothelial cell collection Microvascular perfusion assessment using Definity Microneurography
Group II: Hyperinsulinemic euglycemic clampExperimental Treatment7 Interventions
We will perform following procedures: DEFINITY® infusion Flow mediated vasodilation Endothelial cell collection Microvascular perfusion assessment using Definity Microneurography
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Microneurography
2013
Completed Phase 4
~110
Microvascular perfusion assessment using Definity
2010
Completed Phase 4
~40
Endothelial cell collection
2014
Completed Phase 4
~100
Dextrose infusion
2008
N/A
~30

Find a Location

Who is running the clinical trial?

Wanpen VongpatanasinLead Sponsor
Wanpen Vongpatanasin, MDPrincipal Investigator - UT Southwestern Medical Center
Children's Medical Center of Dallas, The University of Texas Southwestern Medical Center At Dallas, UT Southwestern Medical Center-Zale Lipshy Campus
Chulalongkorn University (Medical School)
University Tx Southwestern Medical Sch (Residency)
11 Previous Clinical Trials
840 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are octogenarians eligible for this experiment?

"The age range prescribed by the inclusion criteria for this trial is between 18 and 75 years old."

Answered by AI

Have there been other investigations into the harvesting of Endothelial cells?

"Currently, 90 clinical trials are underway to research Endothelial cell collection. 14 of these studies have progressed into Phase 3 while the remainder remain in earlier stages. The majority of trial locations for this treatment reside in Sao Luis, MA but there are 273 other sites across the world running similar experiments."

Answered by AI

Is there a particular demographic that is most applicable to join this experiment?

"This research project is looking for two individuals ranging from 18 to 75 years of age, who are currently experiencing hypertension. Additional prerequisites include normotensive controls and Stage I (140-159/90-99 mmHg) untreated subjects with essential hypertension as well as patients already diagnosed with PA at stage one (140-159/90-99 mmHg)."

Answered by AI

What is the participant count of this study?

"Indeed, the records on clinicaltrials.gov demonstrate that recruitment for this research project has commenced. The trial was posted online on November 1st 2010 and updated most recently in March 2022; 2 patients are needed from one medical centre to complete it."

Answered by AI

How is Endothelial cell procurement typically employed therapeutically?

"Endothelial cell collection is regularly prescribed for type 1 diabetes mellitus, as well as echocardiogram, echocardiography and other forms of diabetes."

Answered by AI

Are there opportunities available to join this experiment at the moment?

"Affirmative, information on clinicaltrials.gov reveals that this medical trial is actively recruiting patients at the present time. It was initially listed on November 1st 2010 and its most recent update took place in March 22nd 2022. 2 participants are needed from a single centre to complete the study."

Answered by AI

To what degree is Endothelial cell collection secure for subjects?

"Endothelial cell collection is a safe and approved treatment, thus it received an overall rating of 3."

Answered by AI
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~0 spots leftby Dec 2025