This trial is evaluating whether Amoxicillin will improve 2 primary outcomes and 1 secondary outcome in patients with Hypersensitivity. Measurement will happen over the course of Day 1.
This trial requires 200 total participants across 1 different treatment group
This trial involves a single treatment. Amoxicillin is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 4 and have been shown to be safe and effective in humans.
"The overall rate of HFI sensitivity was 14.3%. Hypersensitivity was more common in females and in Asians. Patients with HFI sensitivity were more likely to receive treatment by non-mainstream physicians. HFI is often a symptom of a more complex disorder or a side-effect of medical treatment. A diagnosis of HFI should prompt physicians to consider the possibility of such underlying conditions." - Anonymous Online Contributor
"What are the signs of hypersensitivity include: itching, wheezing, chest tightness, sweating, and facial edema. Hypersensitivity can be triggered by cold temperatures, or exposure to plants, pesticides, or other materials. It can be classified into three groups: IgE mediated hypersensitivity (drug, insect and plant-arthropod exposures), idiopathic hypersensitivity (sensitization to other allergens), or non IgE hypersensitivity (drugs used for relief of symptoms such as aspirin or opiates). Diagnosing hypersensitivity from other causes is difficult." - Anonymous Online Contributor
"Hypersensitivity is a disorder that can result from a variety of factors, but can be caused by factors that do not affect the body's usual functions. In hypersensitivity, the underlying cause is a reaction to a food, environmental irritant, drug, or allergen, most often resulting in allergic symptoms.\n" - Anonymous Online Contributor
"The combined prevalence of dermatitis contact dermatitis and insect bite hypersensitivity in the United Kingdom are reported here for the first time. An estimate of the number of patients with dermatitis contact dermatitis in the United Kingdom is a more accurate estimate of the global burden of skin and immune related disorders rather than estimating the number of patients with insect bite/pest bites. An estimate of the number of patients with hypersensitivity reactions to medicines in the United Kingdom is a more accurate estimation of the global burden of skin and immune related disorders rather than the number of patients with insect bite/pest bites." - Anonymous Online Contributor
"Hypersensitivity and H1 allergies cannot be cured. However, the benefits of avoiding an allergen to the extent of the individual's abilities may be of greater value in the long-term management of the conditions, even if there is still a risk of developing a allergic reaction. A large reduction in the number of occurrences may result from the reduced quantity of allergen present in the blood. However, as the immune response is suppressed, no rebound effect occurs. The avoidance of a potential allergen must be done on an individual basis." - Anonymous Online Contributor
"This guideline is part of our continuing effort to provide evidence-based medicine to our patients. There are many drugs and techniques that do not pose significant hazards to the patient, but that may nevertheless cause side effects. For these reasons, it is in a patient's best interest to seek the relevant specialists to treat hypersensitivity if present." - Anonymous Online Contributor
"In all the studies, amoxicillin showed effectiveness without side effects against staphylococci, streptococci, and anaerobes, which are commonly present in chronic infections. Further study should be undertaken to determine its benefits in infections caused by these organisms." - Anonymous Online Contributor
"Although the most commonly used coadministered drug is amoxicillin only in about 25% of patients to date and thus the overall use of amoxicillin is limited, several studies, in particular those investigating a possible relationship between the level of amoxicillin resistance and treatment response, suggest that amoxicillin may be useful as a first line drug. These data should be confirmed by multi-center studies, and further studies are needed to assess the potential of amoxicillin for the management of acute sinonasal infections, the treatment of respiratory tract infections in patients with chronic lung disease, or in patients with immunodeficiency, especially with a decreased T cell count." - Anonymous Online Contributor
"In a clinical practice setting, the clinical impact of amoxicillin was modest after 4 months of therapy. To reduce the morbidity and the antibiotic resistance associated with amoxicillin use in the setting of treatment duration greater than 4 months, further studies are needed." - Anonymous Online Contributor
"Subjects who have a history or suspicion of hypersensitivity disorders should consider clinical trial participation. In the case of serious adverse events, if those events are not explained by the clinical trial protocol or other investigations, consideration should be given to an investigation into drugs or medical devices triggering the events." - Anonymous Online Contributor
"Hypersensitivity remains an elusive condition, affecting an estimated 1-3% of the population. Over 400 drug-sensitivities are described. Despite the rarity of the condition, research continues. Most hypersensitivity research is focused on the mechanism by which a sensitizing compound induces hypersensitivity. As hypersensitivity is an autoimmune disease, the mechanisms by which the immune system damages itself to mount an inflammatory response is the goal of many hypersensitivity research studies. Another goal is to identify non-drug-target allergens that could be more useful for immunotherapy, and to learn more about the role of the immune system in sensitization." - Anonymous Online Contributor
"Amoxicillin is well tolerated and safe in infants, toddlers, children, adolescents, and adults. The majority (73%) experienced transient problems but most recovered, with no long-term sequelae. Although amoxicillin may cause gastrointestinal issues, the number reported was small and none had severe sequelae." - Anonymous Online Contributor