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Alkylating agents

Preoperative Subconjunctival injection of MMC for Glaucoma

Phase 4
Waitlist Available
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights

Study Summary

This trial is testing three different methods of delivering MMC for Trabeculectomy in patients with Primary Open Angle Glaucoma who did not have any filtering surgeries before.

Eligible Conditions
  • Glaucoma
  • Open-Angle Glaucoma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
IOP - 1 Day Postop
IOP - 1 Month Postop
IOP - 1 Week Postop
+3 more

Trial Design

3Treatment groups
Active Control
Group I: Preoperative Subconjunctival injection of MMCActive Control1 Intervention
Subconjunctival injection of 0.1 ml of Mitomycin-C 0.002% at the site of future trabeculectomy surgery (2 - 4 weeks preoperatively).
Group II: Intraoperative subconjunctival injection of MMCActive Control1 Intervention
Intraoperative subjconjunctival injection of 0.1 mL of Mitomycin-C 0.01% (0.1mg/mL) to the site of trabeculectomy
Group III: Intraoperative topical application of MMCActive Control1 Intervention
Topical application of Mitomycin-C intraoperatively by applying a sponge soaked in 1mL of Mitomycin-C 0.02 mg/mL for 1 minute to the site of trabeculectomy

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,530 Previous Clinical Trials
10,264,689 Total Patients Enrolled
3 Trials studying Glaucoma
277 Patients Enrolled for Glaucoma

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Might I have the opportunity to partake in this medical experiment?

"Entry into this clinical trial requires participants to have open-angle glaucoma and an age between 20 and 85. The total number of applicants recruited is planned to be 150 individuals."

Answered by AI

What previous investigations have examined the effects of Intraoperative subconjunctival injection of MMC?

"At present, 40 medical studies on Intraoperative subconjunctival injection of MMC are actively underway with 10 in the most advanced stage. Though Bethesda, Maryland homes the bulk of these trials, there are 2029 participating sites around the world."

Answered by AI

What medical conditions often require Intraoperative subconjunctival injection of MMC?

"Intraoperative subconjunctival injection of MMC is a viable option for treating cervical cancers, low-grade upper tract urothelial cancer (lg-utuc), and glaucoma."

Answered by AI

Are there a considerable number of hospitals conducting this experiment in Canada?

"Participants can join this clinical trial at the Doheny Eye Center UCLA (Fountain Valley) in Fountain Valley, Doheny Eye Center UCLA (Arcadia) in Arcadia, and Stein Eye Institute - UCLA (Westwood) located in Los Angeles. Other sites are available as well."

Answered by AI

Are individuals currently being enrolled for this research trial?

"Affirmative, according to information on clinicaltrials.gov this trial is recruiting participants. It was initially posted in March of 2019 and most recently revised in September 2021. The goal is to enlist 150 people from 4 different medical sites."

Answered by AI

Has the FDA validated Intraoperative subconjunctival injection of MMC?

"Our team estimates that Intraoperative subconjunctival injection of MMC is safe, with a score of 3. This treatment has already been approved and thus the Phase 4 trial affords further evidence to its safety record."

Answered by AI

Does this research project accept candidates aged 40 or less?

"Taking into account the study's parameters, participants must be at least 20 years old and no older than 85."

Answered by AI

How many participants are actively engaged in this research endeavor?

"Affirmative. According to the clinicaltrials.gov database, this trial is currently recruiting participants which was initially posted on March 30th 2019 and recently updated on September 29th 2021; 150 patients are needed at 4 different sites."

Answered by AI

Who else is applying?

How old are they?
18 - 65
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Comparing Preoperative Injection of Mitomycin-C vs. Intraoperative Injection of Mitomycin-C vs. Topical Application of Mitomycin-C (Conventional Use) in Trabeculectomy
Joseph Caprioli 2019. "Comparing Preoperative Injection of Mitomycin-C vs. Intraoperative Injection of Mitomycin-C vs. Topical Application of Mitomycin-C (Conventional Use) in Trabeculectomy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03875911.
~3 spots leftby Apr 2025
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