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N-Acetylcysteine Injection for Pilon Fracture
Study Summary
This trial will examine the effects of an amino acid, N-acetylcysteine (NAC), on cartilage cells after an intra-articular fracture of the ankle joint. The goal is to reduce the incidence of post-traumatic osteoarthritis (PTOA) in the ankle joint after fracture.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Media Library
- You are allergic to NAC (N-acetylcysteine).You have a joint injury that doesn't need multiple surgeries to fix.You have a severe fracture in your leg that needs to be treated with multiple surgeries.
- Group 1: N-acetylcysteine (NAC)
- Group 2: Saline
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Drug Has Already Been Approved - The FDA has already approved this drug, and is just seeking more data.
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are patients still being enrolled in this research program?
"That is correct, the clinical trial mentioned is still ongoing and looking for 30 individuals from 1 locations. The information was last updated on 11/2/2022 after being posted on 1/1/2019."
What illnesses does N-acetylcysteine help to treat?
"N-acetylcysteine is often used to heal corneal ulcerations. Additionally, this medication can be effective in treating acute rhinitis, acetaminophen poisoning, and other corneal diseases."
How many study subjects are you testing your hypothesis on?
"That is correct. The information available on clinicaltrials.gov suggests that this particular trial is recruiting patients at the moment. This specific trial was first posted on 1/1/2019 and underwent its most recent update on 11/2/2022. 30 individuals are needed to participate at a single location."
Does N-acetylcysteine have the medical community's seal of approval?
"N-acetylcysteine is a phase 4 medication, so it has been approved and Power rates it as having a safety of 3."
What is the precedent for N-acetylcysteine research?
"As of right now, there are 40 ongoing scientific investigations related to N-acetylcysteine. Out of those 7 are large clinical trials in their third and final phase. Most of the research is based out of New york City, but there are a total 46 locations running these sorts of tests."
Who else is applying?
What state do they live in?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
Why did patients apply to this trial?
How responsive is this trial?
Average response time
- < 2 Days
Most responsive sites:
- University of Missouri Health System: < 48 hours
Typically responds via
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