50% inhaled nitrous oxide for Colonoscopy

Phase-Based Progress Estimates
3
Effectiveness
3
Safety
Stanford University Hospital, Stanford, CA
Colonoscopy+1 More
Nitrous oxide - Drug
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

Nitrous oxide (commonly known as 'laughing gas') is often used during dental and other outpatient procedures, because it is easy to administer, is short-acting and rapidly clears from the body following the procedure. The investigators hypothesize that use of Nitrous oxide during GI endoscopy may enhance patient comfort during the procedure and speed-up post-procedure recovery, while minimizing the fatigue and mental fogginess some patients report the day after receiving standard sedative and narcotic drugs used routinely for the procedure. The investigators are interested in determining if adding Nitrous Oxide to commonly used sedation drugs will decrease fatigue, mental fogginess, and nausea/vomiting, as well as determine when the patient felt fully recovered from the effects of all sedatives given for the procedure.

Eligible Conditions

  • Colonoscopy
  • Endoscopy

Treatment Effectiveness

Effectiveness Progress

3 of 3
This is further along than 93% of similar trials

Study Objectives

7 Primary · 0 Secondary · Reporting Duration: 24-36 hours

24-36 hours
Fatigue
Mental Fogginess post-procedure/sedation
Nausea/vomiting
Return to baseline function
Hour 2
Intravenous sedative drug
Duration of the procedure (1-3hours)
Patient comfort
Recovery time

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Trial Design

2 Treatment Groups

50% inhaled nitrous oxide
1 of 2
5% inhaled nitrous oxide
1 of 2
Active Control
Non-Treatment Group

100 Total Participants · 2 Treatment Groups

Primary Treatment: 50% inhaled nitrous oxide · Has Placebo Group · Phase 4

5% inhaled nitrous oxide
Drug
ShamComparator Group · 1 Intervention: Nitrous oxide · Intervention Types: Drug
50% inhaled nitrous oxide
Drug
ActiveComparator Group · 1 Intervention: Nitrous oxide · Intervention Types: Drug

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 24-36 hours
Closest Location: Stanford University Hospital · Stanford, CA
Photo of california 1Photo of california 2Photo of california 3
2004First Recorded Clinical Trial
1 TrialsResearching Colonoscopy
35 CompletedClinical Trials

Who is running the clinical trial?

Stanford UniversityLead Sponsor
2,130 Previous Clinical Trials
35,668,810 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 3 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
Patient is presenting for upper endoscopy or colonoscopy under endoscopist-directed nurse sedation.
You are willing and able to consent and comply with study procedures.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.