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Estrogen

100mcg estradiol cream for Painful Intercourse

Phase 4
Waitlist Available
Led By Martha Goetsch, MD, MPH
Research Sponsored by Oregon Health and Science University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and 12 weeks
Awards & highlights

Study Summary

This trial will compare the effectiveness of two low doses of estrogen cream applied to a new location for the treatment of moderate or severe pain during sexual intercourse in postmenopausal women.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Median Dyspareunia Pain Scores After 4 Weeks Using Study Drug
Change in Median Pain Scores for Intercourse After 12 Weeks Using Study Drug

Trial Design

2Treatment groups
Active Control
Group I: 100mcg estradiol creamActive Control1 Intervention
Subjects randomized to 100mcg of study medication will be issued a pump that will dispense 0.5gm of cream with each pump
Group II: 50mcg estradiol creamActive Control1 Intervention
Subjects randomized to 50mcg of study medication will be issued a pump that will dispense 0.5gm of cream with each pump

Find a Location

Who is running the clinical trial?

Oregon Health and Science UniversityLead Sponsor
973 Previous Clinical Trials
7,385,762 Total Patients Enrolled
Martha Goetsch, MD, MPHPrincipal InvestigatorOregon Health & Science University, Portland, OR

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this scientific experimentation permit adults over the age of eighteen to participate?

"Participants must be over the age of 40 and below 70 to qualify for this clinical trial."

Answered by AI

How many individuals is this clinical trial recruiting?

"At this juncture, the clinical trial is not looking for new candidates. It was initially posted on June 20th 2017 and has most recently been updated as of September 22nd 2022. If you are seeking other studies though, there are 10 trials recruiting patients with dyspareunia and 50 that require participants to use a50mcg estradiol cream."

Answered by AI

Who is eligible to join this clinical investigation?

"This trial is seeking 50 individuals afflicted with dyspareunia who are between 40 and 70 years old."

Answered by AI

What medical conditions might 50mcg estradiol cream be prescribed to treat?

"Postmenopausal women with an absence of menstruation over the previous six months, hypoestrogenism, and vasomotor symptoms can benefit from a topical application of 50mcg estradiol cream."

Answered by AI

Could you confirm whether enrollment is still available for this trial?

"According to the information recorded on clinicaltrials.gov, this medical trial is not currently in search of participants. Initially posted on June 20th 2017 and recently updated September 22nd 2022, however 60 other research studies are seeking patients at present."

Answered by AI

What has been the regulatory agency's ruling on 50mcg estradiol cream?

"The safety of the 50mcg estradiol cream scored a 3, as this is an approved treatment and its Phase 4 trial further demonstrates its efficacy."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Treating Postmenopausal Dyspareunia Where it Hurts
Jeffrey Jensen 2017. "Treating Postmenopausal Dyspareunia Where it Hurts". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03240081.
~6 spots leftby Apr 2025
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