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Tranexamic acid for Hand Injuries and Disorders (THAW Trial)

Phase 4
Waitlist Available
Research Sponsored by Ruby Grewal
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks
Awards & highlights

THAW Trial Summary

This study is evaluating whether a topical application of tranexamic acid can reduce post-operative hand edema.

Eligible Conditions
  • Hand Injuries and Disorders
  • Dupuytren's Contracture
  • Distal Radius Fracture

THAW Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Adherence to protocol
Recruitment rate
Retention Rate
+1 more
Secondary outcome measures
Hand volume
Patient-reported pain scores

Side effects data

From 2012 Phase 4 trial • 100 Patients • NCT00740116
22%
Readmissions
14%
Postoperative infections
10%
Re-operations
4%
Thromboembolic events
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo Group
Tranexamic Group

THAW Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Tranexamic Acid (TXA)Experimental Treatment2 Interventions
Patients in the TXA arm will receive 1 gram dose of intravenous (IV) tranexamic acid mixed with 50cc 0.9% sodium chloride before their surgery and 1 gram dose of intravenous (IV) tranexamic acid mixed with 50cc 0.9% sodium chloride 3-6 hours after the first dose on the day of their surgery
Group II: Standard of Care (SOC)Placebo Group1 Intervention
Patients in the (SOC) arm will receive 50cc of IV Placebo (standard intravenous normal saline fluid - 0.9% sodium chloride) before their surgery and 50cc of IV Placebo (standard intravenous normal saline fluid - 0.9% sodium chloride) 3-6 hours after the first dose on the day of their surgery
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Surgery
2000
Completed Phase 3
~2550
Tranexamic acid
FDA approved

Find a Location

Who is running the clinical trial?

Ruby GrewalLead Sponsor

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
The Role of Tranexamic Acid in Reducing Post Operative Hand Edema After Hand and Wrist Surgery
Ruby Grewal 2021. "The Role of Tranexamic Acid in Reducing Post Operative Hand Edema After Hand and Wrist Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04907812.
~13 spots leftby Apr 2025
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