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Corticosteroid

Dextenza Arm for Dry Eye Syndrome (ENHANCE Trial)

Phase 4
Waitlist Available
Led By John Passarelli, MD
Research Sponsored by Sight Medical Doctors PLLC
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up post-operative day 7 and 30
Awards & highlights

ENHANCE Trial Summary

This study is evaluating whether a steroid injection may help improve vision for patients with dry eye disease.

Eligible Conditions
  • Dry Eye Syndrome

ENHANCE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~post-operative day 7 and 30
This trial's timeline: 3 weeks for screening, Varies for treatment, and post-operative day 7 and 30 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Mean change from baseline in Standardized Patient Evaluation of Eye Dryness (SPEED) score
Mean change in Early Treatment Diabetic Retinopathy Study (ETDRS) Best Corrected Visual Acuity (BCVA)
Mean change in uncorrected Visual Acuity (VA)
Secondary outcome measures
Mean change from baseline in (Central Subfield Thickness) CST
Mean change in corneal staining
Mean change in tear break-up time (TBUT)
+3 more

ENHANCE Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Dextenza ArmExperimental Treatment1 Intervention
Group II: Prednisolone Acetate 1%Active Control1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Dexamethasone
FDA approved

Find a Location

Who is running the clinical trial?

Ocular Therapeutix, Inc.Industry Sponsor
53 Previous Clinical Trials
5,547 Total Patients Enrolled
Sight Medical Doctors PLLCLead Sponsor
2 Previous Clinical Trials
30 Total Patients Enrolled
John Passarelli, MD4.651 ReviewsPrincipal Investigator - Sight Medical Doctors PLLC
Sight Medical Doctors PLLC
5Patient Review
This post-operative visit went exactly as planned.

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Evaluation Of Vision Recovery And Comfort Index In Patients With Borderline/Mild Dry Eyes Undergoing FLACS With Premium IOL
Dr. John Passarelli 2021. "Evaluation Of Vision Recovery And Comfort Index In Patients With Borderline/Mild Dry Eyes Undergoing FLACS With Premium IOL". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04863742.
All > Vision > Dry Eye
~8 spots leftby Apr 2025
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