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NMDA Receptor Antagonist

Ketamine Group for Depression

Phase 4
Waitlist Available
Led By Charles Hogue, MD
Research Sponsored by Northwestern University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 days before surgery to 30 days after the surgical procedure
Awards & highlights

Study Summary

This trial is looking at whether or not ketamine can help improve depressive symptoms in people who are about to undergo surgery. They will be comparing it to midazolam, and looking at feasibility, safety, and efficacy.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 days before surgery to 30 days after the surgical procedure
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 days before surgery to 30 days after the surgical procedure for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in depressive symptoms in the perioperative period.
Secondary outcome measures
Change in depressive symptoms 1 day after surgery
Safety analsysis of administration of a sub-anesthetic dose of ketamine: CADSS

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Ketamine GroupExperimental Treatment1 Intervention
Ketamine 0.5 mg/kg over 40 min via intravenous catheter.
Group II: MIdazolam GroupActive Control1 Intervention
Midazolam 0.045 mg/kg administered via intravenous catheter.

Find a Location

Who is running the clinical trial?

Northwestern UniversityLead Sponsor
1,586 Previous Clinical Trials
917,251 Total Patients Enrolled
67 Trials studying Depression
28,425 Patients Enrolled for Depression
Charles Hogue, MDPrincipal InvestigatorNorthwestern University
1 Previous Clinical Trials
460 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who is eligible to participate in this research trial?

"This trial seeks 40 melancholic patients aged 18 to 65 who meet the following criteria: Male or female of advanced age, Scheduled lumbar surgery for degenerative vertebrae conditions involving two or more levels, Diagnosis of Major Depressive Disorder (DSM-5) plus a MADRS score ≥ 20, Mini-Mental State Examination (MMSE) between 15 and 26. The ability to comprehend English language is also essential."

Answered by AI

In what ways is Ketamine Group most frequently utilized therapeutically?

"Seizures, particularly epileptic ones, are most often managed with Ketamine Group. This medication is also known to be effective when used for treating amnesia and aiding in certain therapeutic processes."

Answered by AI

What is the current enrollment count for this experiment?

"Correct. Clinicaltrials.gov lists this clinical trial as currently seeking participants, with the initial post dating back to September 1st 2022 and most recent edit on October 3rd 2022. 40 patients are sought from a single medical centre."

Answered by AI

Has the FDA sanctioned Ketamine Group's use?

"Ketamine Group's safety rating is 3, as the treatment has received approval following extensive testing in Phase 4 clinical trials."

Answered by AI

Does the research encompass individuals aged over fifty?

"To be eligible, participants must fall between the ages of 18 and 65. For those too young or old for this trial, 137 studies are available to applicants under 18 years old while 693 trials target individuals older than 65."

Answered by AI

Are there any vacancies available to participants in this medical trial?

"This examination, which was first published on September 1st 2022 is still open and recruiting. The trial's information has been recently modified as of October 3rd 2022 according to clinicaltrials.gov."

Answered by AI

Who else is applying?

What state do they live in?
Illinois
How old are they?
18 - 65
What site did they apply to?
Northwestern University
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Preoperative Ketamine and Perioperative Depression
Charles W Hogue 2022. "Preoperative Ketamine and Perioperative Depression". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04220125.
~0 spots leftby Apr 2025
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