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Virus Therapy

Moderna mRNA-1273 COVID-19 vaccine for Coronavirus

Phase 4
Waitlist Available
Led By Prof. Jens Lundgren
Research Sponsored by National Institute of Allergy and Infectious Diseases (NIAID)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up second vaccine doses were due at 4 and 16 weeks after randomization in arm 2 and 4, respectively
Awards & highlights

Study Summary

This trial is evaluating whether the Moderna or Pfizer vaccine is best administered early or deferred after recovery from COVID-19, and whether one injection provides comparable immune response to a two injection course of vaccination.

Eligible Conditions
  • Coronavirus

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~second vaccine doses were due at 4 and 16 weeks after randomization in arm 2 and 4, respectively
This trial's timeline: 3 weeks for screening, Varies for treatment, and second vaccine doses were due at 4 and 16 weeks after randomization in arm 2 and 4, respectively for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Ratio of 48-Week to Baseline Neutralizing Antibody (NAb) Levels
Secondary outcome measures
Number of Deaths
Number of Patients Non-adherent to 2nd Dose
Number of Patients Non-adherent to Assigned Treatment Strategy
+4 more

Trial Design

4Treatment groups
Experimental Treatment
Group I: Group I2Experimental Treatment2 Interventions
Immediate, two doses. Vaccination at study entry and Week 4
Group II: Group I1Experimental Treatment2 Interventions
Immediate, one dose. Vaccination at study entry
Group III: Group D2Experimental Treatment2 Interventions
Deferred, two doses. Vaccination at Week 12 and Week 16
Group IV: Group D1Experimental Treatment2 Interventions
Deferred, one dose. Vaccination at Week 12 only
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Moderna mRNA-1273 COVID-19 vaccine
2021
Completed Phase 4
~70
Pfizer BNT162b2 COVID-19 vaccine
2021
Completed Phase 4
~70

Find a Location

Who is running the clinical trial?

University of CopenhagenOTHER
912 Previous Clinical Trials
13,327,632 Total Patients Enrolled
Kirby InstituteOTHER_GOV
109 Previous Clinical Trials
186,937 Total Patients Enrolled
Washington D.C. Veterans Affairs Medical CenterFED
39 Previous Clinical Trials
17,971 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there any potential risk associated with the Moderna mRNA-1273 COVID-19 vaccine?

"The Moderna mRNA-1273 COVID-19 vaccine scored a 3 because it is in its fourth stage of trials, indicating that the treatment has successfully been granted approval."

Answered by AI

Is the enrollment period still open for this trial?

"Unfortunately, this trial is not taking partcipants anymore. It was posted on August 25th 2021 and the last update came June 14th 2022. However, there are 1040 studies searching for patients affected by COVID-19 and 43 looking for participants to receive Moderna's mRNA-1273 vaccine."

Answered by AI

Has there been additional research conducted on the efficacy of Moderna mRNA-1273 COVID-19 vaccine?

"In 2020, the Contract Research Organization (CRO) initiated research on Moderna's mRNA-1273 COVID-19 vaccine. Subsequently, 23 trials were brought to completion while 43 studies are currently in progress largely concentrated around Dallas, Texas."

Answered by AI

At how many centers is this clinical experiment taking place?

"This trial is offered at 16 medical sites, including Parkland Health and Hospital Systems (Site 084-002), James Aston Ambulatory Care Center - Clinical Research Unit in Dallas, Duke University Hospital (Site 301-006)in Durham, Rhode island Hospital (Site 080-036) in Providence, as well as 13 other locations."

Answered by AI

Is this medical trial pioneering in its approach?

"BioNTech SE's Moderna mRNA-1273 COVID-19 vaccine has sparked 43 clinical trials, spanning 35 countries and 321 cities. The inaugural study for this immunization was launched in 2020 and included 512 patients who completed both Phases 1 & 2 of drug approval. In the subsequent two years, an additional 23 studies have been conducted."

Answered by AI

What is the enrollment capacity for this scientific endeavor?

"Enrollment for this medical study is not active at the moment; it was originally advertised on August 25th 2021 and last updated June 14th 2022. On the other hand, 1040 trials related to Covid-19 are actively recruiting patients and 43 studies of Moderna mRNA-1273 vaccine also require volunteers."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Vaccination for Recovered Inpatients With COVID-19 (VATICO)
2021. "Vaccination for Recovered Inpatients With COVID-19 (VATICO)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04969250.
~18 spots leftby Apr 2025
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