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Behavioural Intervention

transcranial magnetic stimulator for Apathy

Phase 4
Waitlist Available
Led By Prasad R Padala, MD, MS
Research Sponsored by Central Arkansas Veterans Healthcare System
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 8 weeks
Awards & highlights

Study Summary

Mild cognitive impairment (MCI) is a precursor of dementia. Apathy, a profound loss of motivation, is a common behavioral problem in MCI. Presence of apathy may increase the chance of MCI patients converting to Alzheimer's Dementia. Repetitive Transcranial Magnetic Stimulation (rTMS), a non-invasive tool, has been recently approved for treatment of refractory depression. Since dysfunction in the frontal lobe of the brain is seen in patients with apathy, rTMS to the frontal lobe might be helpful in treating the same. Study hypotheses include that rTMS to the dorsolateral prefrontal cortex (DLPFC) will improve apathy and executive function better than sham treatment in those with MCI

Eligible Conditions
  • Apathy
  • Mild Cognitive Impairment

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Apathy Evaluation Scale (AES)
Secondary outcome measures
Trials making test
Other outcome measures
Exit 25

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: transcranial magnetic stimulatorActive Control1 Intervention
Neurostar repetitive transcranial magnetic stimulator. The active procedure will stimulate at 120% motor threshold for 4 seconds at a frequency of 10 Hz, with an inter-train interval of 26 seconds for a total of 3,000 pulses. 10 treatment sessions are given over a two week period.
Group II: Sham coil treatmentPlacebo Group1 Intervention
Neurostar repetitive transcranial magnetic stimulator. 10 treatments identical in duration will be administered over a two week period.

Find a Location

Who is running the clinical trial?

Central Arkansas Veterans Healthcare SystemLead Sponsor
23 Previous Clinical Trials
3,526 Total Patients Enrolled
2 Trials studying Apathy
145 Patients Enrolled for Apathy
Prasad R Padala, MD, MSPrincipal InvestigatorCentral Arkansas Veterans Healthcare System
1 Previous Clinical Trials
15 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment:Pilot Study
Prasad R. Padala 2014. "Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment:Pilot Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02190019.
All > Transcranial Magnetic Stimulation > Mild Cognitive Impairment
~1 spots leftby Apr 2025
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